Effect of Lidocaine (Xylocaine) on Seizure and Interseizure Electroencephalograms in Epileptics

Böhm, E; Flodmark, Sigvard; Petersén, I.

doi:10.1001/archneurpsyc.1959.02340170016002

Cited by 20 publications

(4 citation statements)

References 7 publications

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“…This discrepancy might be caused by the following reasons. First, most of the previous studies were limited to a small number of patients (1-10 patients); therefore, those high response rates might suggest sampling bias and publication bias (Bernhard et al 1955, Taverner and Bain 1958, Bohm et al 1959, Morris 1979, Pascual et al 1988, De Giorgio et al 1992, Aggarwal and Wali 1993. Second, most of the previous reports did not specify the criteria for efficacy.…”

Section: Discussionmentioning

confidence: 99%

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Intravenous lidocaine for status epilepticus during childhood

Hamano

Sugiyama

Yamashita

et al. 2006

Developmental Medicine &Amp; Child Neurology

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The clinical efficacy of lidocaine for convulsive status epilepticus in 53 convulsive episodes was examined in 37 children (17 males, 20 females). Mean age of patients receiving lidocaine was 3 years 7 months (SD 3y 5mo). Lidocaine administration achieved control of status epilepticus in 19 of 53 convulsive episodes (35.8%). Seizures ceased within 5 minutes of lidocaine administration in all 19 patients who were responsive to the drug. Regarding aetiology of status epilepticus and types of seizures, there was no statistical difference in effectiveness. Mild decrease of oxygen saturation, monitored by pulse oximetry, was observed in one patient, which improved by oxygenation using a mask. Lidocaine is a useful anticonvulsive agent; however, the response rate to lidocaine appears to be quite low, as less than half of the seizures were effectively controlled by lidocaine. Favourable properties of the drug include prompt responses, less alteration of consciousness, and fewer adverse effects, including less respiratory depression.

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Section: Discussionmentioning

confidence: 99%

“…Most of these studies were case reports or were performed on a limited number of patients, i.e. fewer than 10 (Bernhard et al 1955, Taverner and Bain 1958, Bohm et al 1959, Morris 1979, Pascual et al 1988, De Giorgio et al 1992, Aggarwal and Wali 1993. One study of 44 patients was performed 41 years ago (Bernhard and Bohm 1965).…”

mentioning

confidence: 99%

Intravenous lidocaine for status epilepticus during childhood

Hamano

Sugiyama

Yamashita

et al. 2006

Developmental Medicine &Amp; Child Neurology

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“…Primidone. Primidonet was introduced in 1952 by Handley and Stewart,, 9 It has been used in a number of reported series 47 , 71,80,114 but has not been subjected to adequately controlled clinical trials. It would appear from the available data that it is about as effective as phenobarbital in controlling grand mal seizures and may have a salutary effect on patients with psycho-°P aradione.…”

Section: Ftridionementioning

confidence: 99%

“…It was only of partial effectiveness in patients with seizures following intracranial surgical operation and had no effect on myoclonic seizures. s , 9 Anticholinergic agents. Atropine and belladonna in high doses show early promise when used as an anticonvulsant medication in selected patients with minor seizures characterized by a visceral aura.…”

Section: Clinical Pharmacologymentioning

confidence: 99%

Clinical pharmacology of anticonvulsant compounds

Gunn

Gogerty

Wolf

1961

Clin Pharma and Therapeutics

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Anticonvulsant Drug Mechanisms

Sohn

Ferrendelli

1976

Arch Neurol

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Phenytoin, phenobarbital, ethosuximide, and procaine hydrochloride were evaluated for their ability to inhibit Ca2+ flux into isolated presynaptic endings (synaptosomes) prepared from rabbit neocortex. Calcium influx produced by depolarizing concentrations (69 mM) of K+ was inhibited 7% to 63% by phenytoin, phenobarbital, or procaine, whereas ethosuximide was ineffective. Decreased Ca2+ influx was observed with as little as 0.08 mM phenytoin and 0.04 mM phenobarbital. In contrast, 4 mM procaine was needed to produce an effect. These results lead to the conclusion that ability to produce membrane stabilization is not a property of all anticonvulsant drugs; however, this property may be essential for the action of drugs effective in the treatment of major seizures.

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Effect of Lidocaine (Xylocaine) on Seizure and Interseizure Electroencephalograms in Epileptics

Cited by 20 publications

References 7 publications

Intravenous lidocaine for status epilepticus during childhood

Intravenous lidocaine for status epilepticus during childhood

Clinical pharmacology of anticonvulsant compounds

Anticonvulsant Drug Mechanisms

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