Effect of lidocaine spray during colposcopy‐directed cervical biopsy: A randomized controlled trial

Wongluecha, Tanyalak; Tantipalakorn, Charuwan; Charoenkwan, Kittipat; Srisomboon, Jatupol

doi:10.1111/jog.13380

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…The mean post-procedural pain was also higher. The authors do not consider the mentioned study's results reliable due to the lack of placebo use in the control group and lack of full blindness of the patients and colposcopist (22). Our study was different from these two studies in the drug form and dose and larger sample size.…”

Section: Discussionmentioning

confidence: 61%

“…Both groups had the same pain level following biopsy and ECC (21). In a similar study, Wongluecha et al (2017) investigated the effect of 40 mg of lidocaine 10% spray (4 puffs) during colposcopy and cervical biopsy in 200 patients. According to the results, the intra-procedural and post-procedural pains were not different between the intervention and control groups.…”

Section: Discussionmentioning

confidence: 99%

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Analgesic effect of lidocaine in paracervical block in women undergoing colposcopy and cervical biopsy: a randomized clinical trial

Nokhostin¹,

Behdad²,

Mousavi-Roknabadi³

et al. 2021

Preprint

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Objective: To investigate the effect of lidocaine in paracervical block in women undergoing colposcopy and cervical biopsy.Methods: This a triple-blind randomized controlled trial (July-September 2020) was conducted on women who were candidate for the colposcopy and cervical biopsy with American Society of Anesthesiologists classification Class I or II. They were randomly allocated to receive a single dose of lidocaine hydrochloride 2% or injectable sodium chloride 0.9% paracervical block, and then, cervical biopsy was done. The pain score was asked and intra-procedural and 5-minutes post-procedural in both groups, using the VAS tool. Also, patients' satisfaction after the procedure and complications were recorded.Results: Totally, 74 patients (37 in each groups) were enrolled, with the mean±SD age of 35.91±8.10 years. The mean±SD of pain score intra-procedural was statistically higher in patients in the treatment group (0.92±1.53 vs. 2.73±2.34, P<0.001), as well the pain score 5-minutes post-procedural (0.27±0.65 vs. 0.95±1.15, P=0.003). Also, the mean±SD of patients' satisfaction score was higher in the treatment group (4.65±0.82 vs. 4.05±1.41, P=0.03). Dizziness were observed only in the treatment group, statistically (P<0.001).Conclusion: Paracervical block using lidocaine could reduce the intra-procedural and 5-minutes post-procedural pain. Also, it can increase the patients' satisfaction with the procedure.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Analgesic effect of lidocaine in paracervical block in women undergoing colposcopy and cervical biopsy: a randomized clinical trial

Nokhostin¹,

Behdad²,

Mousavi-Roknabadi³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Based on our previous study, lidocaine spray reduces pain during a colposcopy-directed cervical biopsy; however, the clinically meaningful effect of such a procedure cannot be demonstrated. In that study, the majority of participants had only one biopsy taken [13], whereas in current practice, we typically perform CDBs with two or more biopsies, causing more discomfort, as mentioned earlier. Accordingly, while lidocaine spray is attractive because of no risk and is a less invasive method without interfering with colposcopic visualization, the effectiveness of lidocaine spray has never thoroughly studied in relieving the pain associated with CDBs, especially in the cases of two or more biopsies.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Lidocaine Spray for Pain Reduction during Colposcopy-Directed Cervical Biopsies: A Randomized Controlled Trial

Mongkolmafai,

Jeerakornpassawat,

Tantipalakorn

et al. 2024

Medicina

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Objectives: The objective of this study was to evaluate the efficacy of lidocaine spray in reducing the pain during colposcopy-directed cervical biopsy (CDB). Methods: From December 2017 to February 2019, 312 women undergoing CDBs were enrolled. The participants were randomized to three groups: group 1 (lidocaine spray), in which lidocaine spray was applied thoroughly to the cervix; group 2 (placebo), in which normal saline was applied thoroughly to the cervix; and group 3 (control), in which no anesthetic agent was applied to the cervix. Each woman completed a 10 cm visual analog scale to classify the subjective pain experience at three time points: baseline, immediately after biopsy, and 10 min after the procedure. The primary outcome of this study was the biopsy pain score. Results: The 312 enrolled women were randomly assigned to the three groups, amounting to 104 women per group. The clinical and pathological characteristics of the participants in all groups were comparable. The baseline, the biopsy, and the post-procedure pain scores were comparable among the three groups. There was a significant increase in the pain score from baseline to biopsy and from baseline to post-procedure in each group. The pain-score changes from baseline to biopsy in the lidocaine spray group significantly decreased when compared with the normal saline group (<0.001), and tended to decrease, though not significantly (p = 0.06), when compared with the control group. No complication with the intervention was observed. Conclusions: The application of lidocaine spray to the cervix has the benefit of reducing the pain associated with CDBs by a small amount. However, the intervention is safe and may be considered in nulliparous and/or overly anxious women undergoing the procedure.

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“…Colposcopy-directed cervical biopsy is a procedure that is performed on women identified as having an abnormal Pap smear or abnormal human papillomavirus (HPV) test result [6]. This procedure, which causes varying degrees of painfrom mild to severeis typically performed in office settings without the requirement for anesthesia [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Does intravenous lidocaine added to nonsteroidal anti-inflammatory drugs reduce pain during colposcopy? A prospective randomized double-blind study

et al. 2021

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Objectives: In recent years, lidocaine infusion for pain management during long operations is becoming more widespread in anesthesiology practice. However, only a limited number of studies have reported the intravenous use of lidocaine for short-term interventions. The aim of this study was to investigate the effectiveness of intravenous lidocaine use in pain management during colposcopic cervical biopsy and endocervical curettage (ECC). Material and methods:Patients between the ages of 18 and 65 years with abnormal cytological findings or who were determined to be human papillomavirus (HPV)-positive were included in this randomized double-blind study. The lidocaine group (Group L, n = 30) was intravenously administered 50 mg dexketoprofen + 1.5 mg/kg lidocaine in 10 mL saline for 3 min 30 min before the procedure. The control group (Group C, n = 30) was intravenously administered 50 mg dexketoprofen in 10 mL saline for 3 min, 30 min before the procedure. During the procedure, pain scores were assessed using the visual analogue scale (VAS). In addition, patients, operator satisfaction and duration of procedure were assessed.Results: There were no differences in the demographic data of the groups. Pain scores during biopsy and ECC were significantly lower in Group L than in Group C (p < 0.001). The duration of the procedure was significantly shorter in Group L than in Group C (5.00 ± 0.78 vs 6.12 ± 1.16, respectively; p < 0.001). Patient and operator satisfaction were significantly higher in Group L than in Group C (p < 0.001). Conclusions:Intravenous lidocaine administration can be used as an alternative approach to reduce pain and increase operator and patient satisfaction during colposcopy-directed biopsy and ECC procedures in office settings.

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Effect of lidocaine spray during colposcopy‐directed cervical biopsy: A randomized controlled trial

Abstract: Lidocaine spray reduces pain during colposcopy-directed cervical biopsy; however, the clinically meaningful effect of such a procedure cannot be demonstrated in this study.

Cited by 6 publications

References 23 publications

Analgesic effect of lidocaine in paracervical block in women undergoing colposcopy and cervical biopsy: a randomized clinical trial

Analgesic effect of lidocaine in paracervical block in women undergoing colposcopy and cervical biopsy: a randomized clinical trial

Efficacy of Lidocaine Spray for Pain Reduction during Colposcopy-Directed Cervical Biopsies: A Randomized Controlled Trial

Does intravenous lidocaine added to nonsteroidal anti-inflammatory drugs reduce pain during colposcopy? A prospective randomized double-blind study

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