Effect of levodopa treatment on contrast sensitivity in Parkinson's disease

Bulens, C.; Meerwaldt, J. D.; Wildt, G. J. van der; Deursen, J. B. P. van

doi:10.1002/ana.410220313

Cited by 82 publications

(57 citation statements)

References 21 publications

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“…The most prominent interaction between CS disturbance and retinal dopamine has been revealed in patients with motor fluctuations during the «on» and «off» periods. Our evidence of improved CS during the «on» period and reduced CS during the «off» period is agreement with data published by authors from other countries and demonstrates that CS can vary due to the effect of levodopa drugs [20][21][22]. However, what defines the variability of CS fluctuation in different patients is still unknown.…”

Section: IIIsupporting

confidence: 91%

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Oa¹,

Sa²,

Oi³

2017

JNSK

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Among non-motor symptoms in patients with Parkinson's disease (PD) have a number of specific visual disturbances. This review describes the main visual problems associated with PD, referring to their basic anatomical aspects and pathophysiological mechanisms. A wide range of visual disorders includes changes in color vision and contrast sensitivity, change in the electrophysiological properties of the retina due to the insufficiency of the retinal dopaminergic system, features of visual field defects, visuospatial and visuoperceptual impairments. The use of modern electrophysiological, neurophysiological, psychophysiological and other research methods makes it possible to comprehensively assess the state of all parts of the visual analyzer from the retina to the higher cortical centers in patients with PD. The article discusses controversial questions about the relationship between changes in color vision, a decrease in the level of contrast sensitivity and severity of motor disorders in Parkinson's disease. Finally, we discuss the advantages of using threshold and blue-yellow perimetry as more sensitive methods in detecting visual field defects in patients with PD. Keywords:

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Section: IIIsupporting

confidence: 91%

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Oa¹,

Sa²,

Oi³

2017

JNSK

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“…The use of the Farnsworth-Munsell test however needs to take into consideration motor function as there was a correlation between fine motor performance and color discrimination in one study [29]. Additionally, dopaminergic treatment may affect both color discrimination and contrast sensitivity [30,31].…”

Section: While Many Patients With Pd Complain Of Blurred Vision or Nomentioning

confidence: 99%

Premotor Symptoms and Early Diagnosis of Parkinson's Disease

Adler

2011

International Journal of Neuroscience

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“…Such alterations in contrast sensitivity in parkinsonians may be reduced following administration of levodopa (Bulens et al, 1987). Other studies show that patients treated with neuroleptics demonstrate pattern of contrast sensitivity similar to that found in idiopathic Parkinson patients (Bulens et al, 1989).…”

Section: Introductionmentioning

confidence: 74%

Selective effects of low doses of apomorphine on spatiotemporal contrast sensitivity in healthy volunteers: a double‐blind placebo‐ controlled study.

Blin¹,

Mestre²,

Masson³

et al. 1991

Brit J Clinical Pharma

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1. Apomorphine (1 and 5 micrograms kg‐1) and placebo were given to nine normal volunteers, using a Latin‐square design and double‐blind procedures. The visual perception of static and moving patterns (static and motion contrast sensitivity) was evaluated before and 15 min after the dose administration. 2. Apomorphine (1 and 5 micrograms kg‐1), as compared with placebo, led to a significant overall reduction of the visual perception of movement. This effect was dose‐related, and apomorphine (5 micrograms kg‐1) induced a more pronounced decrease in the visual perception of movement than apomorphine (1 microgram kg‐1). With apomorphine (5 micrograms kg‐1), the reduction was more pronounced for low spatial frequencies, and was linearly inversely correlated to the spatial frequency for a temporal frequency of 3 Hz. Finally, no significant effect of apomorphine was observed for sensitivity to static patterns. 3. Several non exclusive hypotheses may be suggested: The effects of apomorphine may result from stimulation of retinal D1‐ and/or D2‐dopaminergic receptors. Apomorphine may increase the surround inhibition of ganglion cells' receptive‐fields. This modification of the centre‐surround balance may explain the decrease in contrast sensitivity for low spatial frequencies. The specific effects of apomorphine on the visual perception of movement support the hypothesis that apomorphine preferentially affects the magnocellular pathway which mediates sensitivity to moving patterns.

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Effect of levodopa treatment on contrast sensitivity in Parkinson's disease

Cited by 82 publications

References 21 publications

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Premotor Symptoms and Early Diagnosis of Parkinson's Disease

Selective effects of low doses of apomorphine on spatiotemporal contrast sensitivity in healthy volunteers: a double‐blind placebo‐ controlled study.

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