Effect of levamisole, Vitamin E, and selenium against aflatoxicosis in broilers chicken

Ulaiwi, Amjed H.

doi:10.14202/vetworld.2018.248-253

Cited by 11 publications

(4 citation statements)

References 8 publications

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“…Elevated levels of serum AST and GGT were observed in birds receiving 0.5 ppm of AF as compared to control group chickens, indicating considerable damage to the liver. Similar findings of elevated activities of serum enzymes due to aflatoxicosis were observed by many researchers [25][26][27]). Raju and Devegowda (2000) recorded no difference in AST levels in birds fed AF up to 0.3 ppm for 21 days [25].…”

Section: Discussionsupporting

confidence: 88%

The Efficacy of a Smectite-Based Mycotoxin Binder in Reducing Aflatoxin B1 Toxicity on Performance, Health and Histopathology of Broiler Chickens

Zabiulla

Malathi

Swamy

et al. 2021

Toxins

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The aim of the experiment was to investigate the efficacy of a smectite-based clay binder (Toxo-MX) in reducing the toxicological effects of aflatoxin B1 (AFB1) in commercial broiler chickens. A total of 450 one-day old male broiler chickens were randomly allocated into three treatment groups with ten replicates of 15 birds each in a 42-day feeding experiment. The dietary treatments included a negative control (NC, a basal diet with no AFB1 and binder), a positive control (PC, a basal diet contaminated with 500 ppb of AFB1) and a smectite-based mycotoxin binder(Toxo-MX, PC with smectite clay binder). AFB1 challenge resulted in 14 to 24% depression in growth performance, elevated levels of aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), organ enlargement and immuno-suppression.As compared to PC, feeding of Toxo-MX improved the final weight (15%; p < 0.0001), average daily gain (ADG) (15%; p < 0.001) and feed efficiency of broilers (13%; p < 0.0003) but did not have any effects on liver enzyme activities. Supplementation of smectite claysignificantly increased serum globulin levels and reduced the weight of the liver (p < 0.05) as compared to AFB1-fed broiler chickens. The severity of lesions (inflammatory and degenerative changes) observed in the liver, kidney, heart, pancreas, and lymphoid organs in PC birds was reduced by feeding smectite clay. The immuno-suppression caused by AFB1 was moderately ameliorated in Toxo-MX groupby stimulating the production of antibodies against IBD at day 42 (p < 0.05). In conclusion, dietary supplementation of a smectite-based mycotoxin binder to the diet containing AFB1 improved growth performance, reduced toxicological effects in liver and improved humoral immune response in broilers, suggesting its protective effect against aflatoxicosis.

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Section: Discussionsupporting

confidence: 88%

The Efficacy of a Smectite-Based Mycotoxin Binder in Reducing Aflatoxin B1 Toxicity on Performance, Health and Histopathology of Broiler Chickens

Zabiulla

Malathi

Swamy

et al. 2021

Toxins

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“…The MDA levels in the blood, liver, heart, and pectoral muscles were remarkably elevated, whereas the levels of antioxidants indices GSH-Px, T-AOC, T-SOD, and CAT as well as mRNA expression of antioxidant genes GPx-1 , GPx-2 , GPx-4 , DIO-1 , and SOD-1 in the liver of chicks (day 1 and 14) were reduced in the control group, however, the supplementation of the combination of dietary Q + VE reverted the oxidative stress effects in the blood, liver, heart, and pectoral muscles by elevating the levels of antioxidants indices GSH-Px, T-AOC, T-SOD, and CAT, and upregulates the antioxidant genes GPx-1 , GPx-2 , GPx-4 , DIO-1 , and SOD-1 at both time points. These results were consistent with the studies by Ulaiwi (2018) and Torki et al (2018) which reported that the combination of levamisole, vitamin E, and selenium and quercetin, oat hulls, β-glucans, lysozyme, and fish oil, respectively reduce oxidative stress in broiler chicks.…”

Section: Discussionsupporting

confidence: 93%

Synergy Between Dietary Quercetin and Vitamin E Supplementation in Aged Hen’s Diet Improves Hatching Traits, Embryo Quality, and Antioxidant Capacity of Chicks Hatched From Eggs Subjected to Prolonged Storage

Amevor

Cui

et al. 2022

Front. Physiol.

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The current study aims to investigate the effects of the synergy between quercetin and vitamin E in aged hen’s diet on hatchability and antioxidant levels of the embryo and newly hatched chicks from prolonged storage eggs. A total of 400 breeder laying hens of 65 weeks of age were selected and randomly divided into 4 groups. Birds were fed a basal diet alone (Control), and basal diets supplemented with quercetin (Q) (0.4 g/kg) and vitamin E (VE) (0.2 g/kg) alone and their combination (0.4 g/kg Q + 0.2 g/kg VE) for 14 weeks, respectively, to determine their effects on yolk antioxidant status, fertility, embryonic mortality, hatchability, antioxidant status of embryonic tissues, as well as the antioxidant status of the newly hatched chicks. The results showed that the hen’s dietary Q + VE increased the yolk weight, as well as increased the antioxidant status of the egg yolk (p < 0.05). Compared with the control group, the supplementation of Q + VE significantly increased the hatchability of set-fertile eggs and decreased early embryonic mortality in eggs stored for 7 and 14 days, respectively (p < 0.05), and also improved the antioxidant capacity of the embryos obtained from eggs stored for 14 days (before incubation) (p < 0.05). Moreover, Q + VE increased the levels of SOD, GSH-Px, T-AOC, T-SOD, and CAT in the liver, heart, and pectoral muscle of the embryo, 1-day-old and 14-day-old chicks (p < 0.05), as well as upregulated the antioxidant related genes (GPx-1, GPx-2, GPx-4, DIO-1, and SOD-1) in the liver of the embryo, 1-day-old and 14-day-old chicks hatched from 14-days storage eggs (p < 0.05). Meanwhile, the MDA levels were decreased by the Q + VE in the embryo and post-hatched chicks (p < 0.05). In conclusion, these findings suggested that maternal dietary Q + VE exerts beneficial synergistic effects on the antioxidant capacity of the egg yolk, embryo, and chicks during prolong egg storage, therefore, Q + VE could be used as a dietary measure to enhance hatchability and chick quality in poultry production.

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“…The summary effect size is denoted by the blue diamond. References: Liu et al [ 29 ], Subhani et al [ 26 ], Rajput et al [ 28 ], Sridhar et al [ 30 ], Solis-Cruz et al [ 25 ], Sridhar et al [ 32 ], Bintvihok et al [ 34 ], Sadeghi et al [ 31 ], Muhammad et al [ 33 ], Nabi et al [ 21 ], Cao et al [ 8 ], Almusawi et al [ 24 ], Malekinezhad et al [ 22 ], Rashidi et al [ 23 ], Ulaiwi et al [ 27 ], Lin et al [ 19 ], Mesgar et al [ 20 ], Muhammad et al [ 33 ], Rashidi et al [ 23 ], Pappas et al [ 44 ], Allameh et al [ 5 ], Almusawi et al [ 24 ], Mahrose et al [ 41 ], Pappas et al [ 44 ], Barati et al [ 7 ], Rashidi et al [ 23 ], Valchev et al [ 42 ], Xie et al [ 4 ], Stanley et al [ 40 ], Ejiofor et al [ 36 ], Allameh et al [ 5 ], Motawe et al [ 38 ], Barati et al [ 7 ], Rashidi et al [ 23 ], Basmacioglu et al [ 39 ], Hernandez-Ramires et al [ 36 ], Solis-Cruz et al [ 25 ], Cao et al [ 8 ], Salem et al [ 37 ], Barati et al [ 7 ], Ulaiwi et al [ 27 ], Mahrose et al [ 41 ], Pappas et al [ 44 ].…”

Section: Figurementioning

confidence: 99%

The Efficacy of Additives for the Mitigation of Aflatoxins in Animal Feed: A Systematic Review and Network Meta-Analysis

Kolawole

Siri-anusornsak

Petchkongkaew

et al. 2022

Toxins

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The contamination of animal feed with aflatoxins is an ongoing and growing serious issue, particularly for livestock farmers in tropical and subtropical regions. Exposure of animals to an aflatoxin-contaminated diet impairs feed efficiency and increases susceptibility to diseases, resulting in mortality, feed waste, and increased production costs. They can also be excreted in milk and thus pose a significant human health risk. This systematic review and network meta-analysis aim to compare and identify the most effective intervention to alleviate the negative impact of aflatoxins on the important livestock sector, poultry production. Eligible studies on the efficacy of feed additives to mitigate the toxic effect of aflatoxins in poultry were retrieved from different databases. Additives were classified into three categories based on their mode of action and composition: organic binder, inorganic binder, and antioxidant. Moreover, alanine transaminase (ALT), a liver enzyme, was the primary indicator. Supplementing aflatoxin-contaminated feeds with different categories of additives significantly reduces serum ALT levels (p < 0.001) compared with birds fed only a contaminated diet. Inorganic binder (P-score 0.8615) was ranked to be the most efficient in terms of counteracting the toxic effect of aflatoxins, followed by antioxidant (P-score 0.6159) and organic binder (P-score 0.5018). These findings will have significant importance for farmers, veterinarians, and animal nutrition companies when deciding which type of additives to use for mitigating exposure to aflatoxins, thus improving food security and the livelihoods of smallholder farmers in developing countries.

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Effect of levamisole, Vitamin E, and selenium against aflatoxicosis in broilers chicken

Cited by 11 publications

References 8 publications

The Efficacy of a Smectite-Based Mycotoxin Binder in Reducing Aflatoxin B1 Toxicity on Performance, Health and Histopathology of Broiler Chickens

The Efficacy of a Smectite-Based Mycotoxin Binder in Reducing Aflatoxin B1 Toxicity on Performance, Health and Histopathology of Broiler Chickens

Synergy Between Dietary Quercetin and Vitamin E Supplementation in Aged Hen’s Diet Improves Hatching Traits, Embryo Quality, and Antioxidant Capacity of Chicks Hatched From Eggs Subjected to Prolonged Storage

The Efficacy of Additives for the Mitigation of Aflatoxins in Animal Feed: A Systematic Review and Network Meta-Analysis

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