Effect of Left Ventricular Reverse Remodeling on Long-Term Prognosis After Therapy With Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers and β Blockers in Patients With Idiopathic Dilated Cardiomyopathy

Hoshikawa, Eri; Matsumura, Yuichi; Kubo, Toru; Okawa, Makoto; Yamasaki, Naohito; Kitaoka, Hiroaki; Furuno, Takashi; Takata, Jun; Doi, Yoshinori

doi:10.1016/j.amjcard.2010.11.033

Cited by 67 publications

(50 citation statements)

References 23 publications

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“…In contrast to other studies associating low ejection fraction with poor prognosis, 17 we found that lower LVEF at presentation is an independent predictor of PIEF. We believe that a recent-onset disease (characterized by subacute presentation) allows for a greater opportunity to intervene and respond to the modern heart failure therapy (Table 2).…”

Section: Discussioncontrasting

confidence: 99%

Predictors and Outcome of Sustained Improvement in Left Ventricular Function in Dilated Cardiomyopathy

Blechman

Arad

Nussbaum

et al. 2014

Clinical Cardiology

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BackgroundImprovement in the left ventricular ejection fraction (LVEF) may occur in patients with dilated cardiomyopathy (DCM).HypothesisThere are different implications of persistent versus transient improvement in LVEF among DCM patients receiving contemporary therapy.MethodsWe studied 188 patients with nonischemic DCM. Persistent improvement in LVEF (PIEF) was defined as LVEF increase by at least 10% compared to baseline, and found in 2 separate echo‐Doppler exams performed at least 12 months apart. Increased LVEF in echo 2, which was not sustained in echo 3, was defined as transient improvement in LVEF (TIEF).ResultsOver an average follow‐up of 6.8 years, PIEF occurred in 61 (33%) patients, predicting a better long‐term outcome (P < 0.001) in a combined end‐point comprising death, heart transplantation, or the need for a ventricular assist device. The TIEF group had an intermediate course and were closer to nonimprovers (P = 0.003 vs PIEF). Multivariate logistic regression identified the following independent predictors of PIEF: shorter disease duration, pregnancy‐associated disease, left ventricular hypertrophy, and baseline LVEF ≤25%. A score to predict PIEF assigned 1 point to each of the following: disease duration <3 years and no familial cardiomyopathy; pregnancy‐associated presentation; basal LVEF ≤25%; and left ventricular wall thickness ≥12. A score of ≥3 was present in 44% of the patients, reliably predicting PIEF in 91% (P = 0.01).ConclusionsPersistent improvement in LVEF is associated with improved long‐term prognosis. Baseline clinical parameters can be used to identify patients likely to demonstrate PIEF, thereby allowing tailored management in this population.

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Section: Discussioncontrasting

confidence: 99%

Predictors and Outcome of Sustained Improvement in Left Ventricular Function in Dilated Cardiomyopathy

Blechman

Arad

Nussbaum

et al. 2014

Clinical Cardiology

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Section: Clinical Events After the Midterm Evaluation Of Lvrr And Nt-mentioning

confidence: 99%

“…7, 8 A study of 43 patients with NIDCM reported a significant improvement in survival rate in the patients with LVRR. 8 Another study demonstrated that a prognostic model that combines baseline and midterm follow-up data predicts the prognosis with improved accuracy. 7 In the current study, patients with LVRR and lower midterm NTproBNP level showed excellent long-term prognosis (Figure 2), which suggests that the structural and functional monitoring of HF is important for identifying the future risk of adverse events.…”

Section: Clinical Events After the Midterm Evaluation Of Lvrr And Nt-mentioning

confidence: 99%

Predictors of Left Ventricular Reverse Remodeling and Subsequent Outcome in Nonischemic Dilated Cardiomyopathy

Choi

Kim

Lee

et al. 2013

Circ J

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“…Second, overall medications may influence the results between experimental and control groups. Previous studies show that β-blockers, in addition to ACE inhibitors or ARBs, have beneficial effects on left ventricular remodeling [29]. Nearchou et al [30] reported that ACE inhibitor therapy improved ventricle performance and Tei index during the early phase of inferior acute myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Coronary Ectasia Is Associated with Impaired Left Ventricular Myocardial Performance in Patients without Significant Coronary Artery Stenosis

Ceyhan

Koç²,

Özdemi̇r³

et al. 2011

Med Princ Pract

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Objectives: To determine both ventricular functions and tissue Doppler echocardiography (TDE)-derived myocardial performance index (MPI) in patients with coronary artery ectasia (CAE). Subjects and Methods: Twenty-five patients with CAE (13 men; mean age 57 ± 9 years) and 25 age- and sex-matched controls without CAE (8 men; mean age 54 ± 10 years) were enrolled in the study. Left and right ventricular functions were detected using conventional echocardiography and TDE. Results: Left ventricle-lateral wall (0.61 ± 0.17; 0.50 ± 0.10, p = 0.02), interventricular septum (0.66 ± 0.17; 0.52 ± 0.10, p = 0.007) and mean MPI (0.63 ± 0.15; 0.51 ± 0.09, p = 0.004) were increased in the CAE group compared to the control group. Right ventricular MPI was similar in both the CAE and control groups (0.58 ± 0.18; 0.52 ± 0.19, p > 0.05). Conclusion: The findings show that left ventricular MPI is different in CAE patients without obstructive coronary artery disease compared to the normal control group. Also in these patients, right ventricular MPI was similar to the control group.

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Effect of Left Ventricular Reverse Remodeling on Long-Term Prognosis After Therapy With Angiotensin-Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers and β Blockers in Patients With Idiopathic Dilated Cardiomyopathy

Cited by 67 publications

References 23 publications

Predictors and Outcome of Sustained Improvement in Left Ventricular Function in Dilated Cardiomyopathy

Predictors and Outcome of Sustained Improvement in Left Ventricular Function in Dilated Cardiomyopathy

Predictors of Left Ventricular Reverse Remodeling and Subsequent Outcome in Nonischemic Dilated Cardiomyopathy

Coronary Ectasia Is Associated with Impaired Left Ventricular Myocardial Performance in Patients without Significant Coronary Artery Stenosis

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