Effect of lead on some haematological and biochemical characteristics of Clarias gariepinus dietary supplemented with lycopene and vitamin E

Mahmoud, Usama M.; Ebied, Abdel M.; Mohamed, Sherif

doi:10.21608/eajbsc.2013.16112

Cited by 12 publications

(16 citation statements)

References 73 publications

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“…There is also good evidence linking mercury with anemia, including hemolytic anemia and aplastic anemia as mercury is thought to compete with iron for binding to hemoglobin which can result in the impaired hemoglobin formation (Pyszel et al, 2005). The present finding came accordance with the results of Adeyemo (2007) and Mahmoud et al (2013) who observed a decrease in RBC, Hb, and Hct values in Clarias gariepinus exposed to lead.…”

Section: Discussionsupporting

confidence: 93%

“…Abdel El -Moneium et al (2008) showed an insignificant difference in blood urea and significant increase in creatinine after exposure Clarias lazera to different doses of industrial effluent. An increase in the urea and creatinine in Clarias gariepinus after exposure to mercury and Pb was observed (Mahmoud et al, 2013). Zaki et al (2014) reported that long term exposure of Clarias lazera to mercuric chloride and/or to Pb, Hg, Ca and/or lead acetate caused gradual elevation of serum urea and creatinine.…”

Section: Discussionmentioning

confidence: 98%

“…Metals are well known inducers of oxidative damage in fishes reflecting metal contamination of the aquatic ecosystem (Kumar and Nandan, 2014). Antioxidant is an agent that can neutralize the oxidant effect of free radicals, including some natural and other substances (Mahmoud et al, 2013). Meso-2, 3-dimercaptosuccinic acid (DMSA) is a dithiol compound, has two-SH groups (Flora et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Monitoring of Oxidative Stress Biomarkers and Toxicity of Lead and Mercury in Catfish of Lake Mariout, Egypt: The Role of Meso -2, 3-Dimercaptosuccinic Acid (DMSA)

Mohamed¹,

Ali²,

Bakhoum³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

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The present investigation was designed to evaluate the dangerous effects of the Pb and Hg on Clarias gariepinus inhabiting Lake Mariout and assay the possible protective effect of meso-2, 3 dimercaptosuccinic acid (DMSA). The test fish were divided into four groups kept in plastic tanks (20 fish each) containing 30L of Lake Mariout water. Group (1): Standard group (zero time); Group (2): Unexposed DMSA group, Group (3): Low dose DMSA group; Group (4): High dose DMSA group. Fish exposed to DMSA showed significant decrease in lead (P≤0.05) and mercury concentrations (P≤0.05) in kidney, liver, gills, muscle and blood than unexposed group. The present results clearly indicate a significant decrease in RBCs, Hb, Hct, and platelet counts while a significant increase in MCH, MCHC, and WBCs in the Clarias gariepinus collected from the main basin of Lake Mariout. A marked significant decrease in AST, ALT, urea, creatinine (P≤0.05) was observed in DMSA groups. A significant increase in CAT, GPX and SOD was observed after exposure to DMSA. In addition, DMSA exposure improved the histopathological alterations in fish liver and kidney.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Monitoring of Oxidative Stress Biomarkers and Toxicity of Lead and Mercury in Catfish of Lake Mariout, Egypt: The Role of Meso -2, 3-Dimercaptosuccinic Acid (DMSA)

Mohamed¹,

Ali²,

Bakhoum³

et al. 2019

Egypt. J. of Aquatic Biolo. and Fish.

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“…Research studies on lead have been carried out on humans and fishes. On fishes, Clarias gariepinus, it was observed that lead significantly cause a decline in haemoglobin levels, packed cell volume and red blood cell counts [7], but base on exposure to lead from petroleum products as observed in automobile workers, there is a significant increase in blood lead (P<0.001) in the research study by [8].…”

Section: Introductionmentioning

confidence: 76%

Effect of Petroleum on Haematological Parameters and Lead Level in Fuel Attendants in Port Harcourt, Nigeria

2016

IJSR

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Petroleum is a thick, flammable, yellow-to-black mixture of gaseous, liquid, and solid hydrocarbons that occur naturally beneath the earth's surface, its products are got from fractional distillation of crude. These products are normally dispensed from reservoir by fuel attendants to motorist and individuals that needs these products for domestic uses. Occupational exposure to petroleum products has been reported to have toxic effects on humans with much impact on the respiratory system. The aim of our study was to investigate the effect of petroleum products on haematological parameters and lead levels. Fifty eight (58) adult human subjects aged between 19 to 52 years were recruited for the study after they gave us consent. Questionnaires were distributed to participants and it was filled with proper guidance. Eight fuel stations located in Port Harcourt, Nigeria, were used as locations for the study and they represent the test subjects, while students from Rivers State University of Science and Technology, Port Harcourt, were recruited as control subjects. A total of eighteen (18) females were enrolled in the study, nine (9) of them for test and control subjects, while a total of 40 males were enrolled, 20 of them for test and control subjects. Graphpad Prism 5.0 statistical package was used to analyse the data obtained. From our findings, there was no statistically significant difference (p≤0.05) in most haematological parameters (haemoglobin level, packed cell volume, platelets) and levels of lead in fuel attendants and control subjects. The white blood cells indicated a highly significant difference (p = 0.0001) in fuel attendants and may be as a result of chronic exposure to lead and petroleum products.

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“…Незважаючи на наявність експериментальних даних щодо хронічної та гострої інтоксикації свинцем у літературі відмічено дефіцит морфологічних даних щодо впливу свинцю під час раннього морфогенезу серця та корекції токсичного впливу сполук свинцю. [8,13] Мета роботивстановити зміни морфогенезу серця на пренатальному етапі за експозиції ацетату свинцю та лікопіну і інуліну у щурів.…”

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Immunohistochemical Study of Heart Morphogenesis Disorders in Rats in Terms of Lead Acetate Exposure at the Prenatal Stage of their Development

Shevchenko¹

2019

Ukr. ž. med. bìol. sportu

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Effect of lead on some haematological and biochemical characteristics of Clarias gariepinus dietary supplemented with lycopene and vitamin E

Cited by 12 publications

References 73 publications

Monitoring of Oxidative Stress Biomarkers and Toxicity of Lead and Mercury in Catfish of Lake Mariout, Egypt: The Role of Meso -2, 3-Dimercaptosuccinic Acid (DMSA)

Monitoring of Oxidative Stress Biomarkers and Toxicity of Lead and Mercury in Catfish of Lake Mariout, Egypt: The Role of Meso -2, 3-Dimercaptosuccinic Acid (DMSA)

Effect of Petroleum on Haematological Parameters and Lead Level in Fuel Attendants in Port Harcourt, Nigeria

Immunohistochemical Study of Heart Morphogenesis Disorders in Rats in Terms of Lead Acetate Exposure at the Prenatal Stage of their Development

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