Effect of lead exposure on the immune response of some occupationally exposed individuals

Mishra, K.P.; Singh, Vijay Kumar; Rani, Reena; Yadav, V. S.; Chandran, Vinod; Srivastava, S. P.; Seth, Prahlad K.

doi:10.1016/s0300-483x(03)00091-x

Cited by 99 publications

(59 citation statements)

References 40 publications

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“…Lead exposure can result in impaired immune function of T-lymphocytes and erythrocytes, and a delayed immune response [21,22]. There was a decrease in the percentage of CD4+ and significant increase in CD8+ cells in children exposed to high lead levels [23].…”

Section: Effect Of Lead On the Immune System Thus Increasing The Bodmentioning

confidence: 99%

A Complex Adaptive System in Which Environmental Stress Affects Gene Expression During Development

KOH

TOH

O’DONNELL

et al. 2017

WIT Transactions on State-of-the-Art in Science and Engineering

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Dental development is a complex adaptive system influenced by genetic-epigenetic-environmental factors. The mature dentition is a paradigm for general development and is an accessible, permanent record of interactions affecting development from 6 weeks in-utero to 20 years of age. Published research on the dentition of a large group of Romano-Britons has indicated that three major environmental insults acting throughout the developmental period are associated with high frequencies of dental variations. Based on those studies and the literature, the aetiological network incorporates the effects of excessive lead ingestion, poor nutrition and infections on the endocrine and immune systems, epigenome and gene expression. The environmental insults act independently and synergistically on both the endocrine and immune systems, which in turn have reciprocal interactions with each other, as well as on the epigenome. Thus, a complex subnetwork influences the epigenome and modifies one or more of three mechanisms by which it controls gene expression, that is, DNA methylation, post-translational histone modification and microRNA expression. The environmental-epigeneticgenetic interactions behave as a complex adaptive system that can be illustrated in a network diagram. The epigenetic modifications can have long-term health effects in the individual and some may also be heritable.

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Section: Effect Of Lead On the Immune System Thus Increasing The Bodmentioning

confidence: 99%

A Complex Adaptive System in Which Environmental Stress Affects Gene Expression During Development

KOH

TOH

O’DONNELL

et al. 2017

WIT Transactions on State-of-the-Art in Science and Engineering

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“…La exposición aguda o crónica a plomo ha sido un tema de gran preocupación en el campo de la salud, sobre todo por su utilización en diversas actividades como la elaboración de baterías, pinturas, barnices y compuestos antidetonantes en la gasolina (Mishra et al, 2003); de allí que la exposición ocupacional sea un gran problema (Evans et al, 2010;Poręba et al, 2010). Los efectos tóxicos del plomo son conocidos por su impacto negativo en varios sistemas esenciales del cuerpo humano, tales como, el sistema nervioso, el reproductivo y el cardiovascular (Hernández-Ochoa et al, 2005;Basha et al, 2013).…”

Section: Introductionunclassified

Revisión de las implicaciones ocupacionales por exposición al plomo.

Pájaro-Castro¹,

Rojas²,

Gari

et al. 2013

Inf. Téc.

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El plomo, considerado uno de los metales tóxicos más comunes en el medio ambiente, es frecuentemente utilizado en el mundo para la fabricación de armas, baterías y aditivos para la gasolina, entre otras aplicaciones. La exposición cró- nica a este contaminante es un problema de salud pública que afecta sistemas importantes como el nervioso, el reproductivo y el circulatorio. En varios países la búsqueda de materiales que reemplacen el plomo ha sido implementada con buenos resultados. En Colombia no existen regulaciones nacionales concretas que garanticen el desempeño ocupacional en ambientes libres de plomo, por lo que se hace necesaria la creación de regulaciones que permitan minimizar el riesgo de exposición a este metal tóxico.

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“…17 Blood Pb has positive correlation with the symptoms of Pb toxicity. 18 Over the past several years, Pb poisoning has attracted growing attention in the developed countries. At the same time, however, this problem has not been a subject of concern in most developing countries, including Pakistan, with low literacy rate.…”

Section: Introductionmentioning

confidence: 99%

Exposures of lead to adolescent workers in battery recycling workshops and surrounding communities

Shah

Kazi

Afridi

et al. 2012

J Expo Sci Environ Epidemiol

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In the present study, the environmental and occupational exposure of lead (Pb) has been assessed by analyzing the wholeblood samples of early adolescents (boys) aged 12--15 years working for the past 1--3 years in battery recycling workshops (BRW). For comparative purpose, boys of the same age group residing in the vicinity of BRW (exposed non-workers) and who lived in domestic areas devoid of any industrial activity (referents boys) were selected. The blood samples were analyzed for Pb, along with biochemical parameters of blood. Both biological samples were oxidized by acid in a microwave oven before determination of Pb by graphite furnace atomic absorption spectrometry. The mean value of Pb concentration in blood samples of working boys was threefold higher as compared with referent boys. The significant negative correlations of blood Pb level with % Hb (r ¼ À0.862) were observed in working boys.

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Effect of lead exposure on the immune response of some occupationally exposed individuals

Cited by 99 publications

References 40 publications

A Complex Adaptive System in Which Environmental Stress Affects Gene Expression During Development

A Complex Adaptive System in Which Environmental Stress Affects Gene Expression During Development

Revisión de las implicaciones ocupacionales por exposición al plomo.

Exposures of lead to adolescent workers in battery recycling workshops and surrounding communities

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