Effect of laxatives on gastrointestinal functional recovery in fast-track hysterectomy: a double-blind, placebo-controlled randomized study

Hansen, Charlotte T.; Sørensen, M.K.; Møller, Charlotte; Ottesen, Bent; Kehlet, Henrik

doi:10.1016/j.ajog.2006.10.902

Cited by 60 publications

(61 citation statements)

References 18 publications

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“…This effect of laparoscopy in comparison to open surgery has been demonstrated in a recent RCT under traditional perioperative care as well as ERAS [111]. Oral magnesium oxide was demonstrated to promote postoperative bowel function in a double-blinded RCT in abdominal hysterectomy [160] and in reports from a well-established enhanced recovery program in colonic resection [1,161]. Another randomised trial in liver resection showed that oral magnesium enhanced the return of bowel function [162] [164].…”

Section: Summary and Recommendationmentioning

confidence: 87%

Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations

et al. 2012

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Background This review aims to present a consensus for optimal perioperative care in colonic surgery and to provide graded recommendations for items for an evidencedbased enhanced perioperative protocol. Methods Studies were selected with particular attention paid to meta-analyses, randomised controlled trials and large prospective cohorts. For each item of the perioperative treatment pathway, available English-language literature was examined, reviewed and graded. A consensus recommendation was reached after critical appraisal of the literature by the group. Results For most of the protocol items, recommendations are based on good-quality trials or meta-analyses of goodquality trials (quality of evidence and recommendations according to the GRADE system). Conclusions Based on the evidence available for each item of the multimodal perioperative care pathway, the Enhanced

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Section: Summary and Recommendationmentioning

confidence: 87%

Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations

et al. 2012

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“…A minority of these fasttrack protocols include the use of laxatives, mostly magnesia, an osmotic agent without colon-stimulating properties [7,9,43,44]. The inclusion of a colonstimulating laxative in rehabilitation programs may confer additional benefit by decreasing the duration of colonic hypomotility.…”

Section: Discussionmentioning

confidence: 99%

Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial

Zingg

Mišković

Pasternak

et al. 2008

Int J Colorectal Dis

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“…Improving GI function is also an area we have identified as worthy of further study. Simple techniques such as initiating a regular chewing gum regimen after surgery to stimulate bowel function has been shown to be effective and would add little financial impost and minimal risk of increased morbidity [14][15][16][17][18][19]. Health care organisations and Hospital Administrators also derive significant financial benefit from a FTS program and should provide funding for the initiation and maintenance of such programs.…”

Section: Discussionmentioning

confidence: 99%

Early discharge after major gynaecological surgery: advantages of fast track surgery

Carter

Philp²,

Arora³

2011

OJOG

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Introduction: Fast Track Surgery (FTS) programs have been adopted by many specialties with documented improved patient outcomes and reduced length of stay (LOS). Methods: We initiated a FTS program in January 2008 and present our experience up to and including November 2010 on patients whose LOS was 2 days. Results: During the study period 242 patients had a laparotomy performed. Overall 54 (22.3%) patients were discharged on day 2. In the first year of initiating our FTS program 10% were discharged on day 2, 25% in year 2 and 31% in year 3. Twenty-two patients (41%) had malignant pathology and of these, 16 (73%) had local or regional spread and 6 (27%) had distant spread. Forty patients (74%) had vertical midline incisions (VMI) performed. Surgery was classified as complex in 40 cases (74%) and 6 (11%) patients underwent staging lymph node dissection. Average patient BMI was 26.1 with 44% of patients considered overweight or obese. There were no intraoperative complications recorded. When compared to 188 patients whose LOS was greater than 2 days, the early discharge cohort were more likely to have benign pathology, more likely to be younger, to have a transverse incision, to have received COX II inhibitors, to have a lower net haemoglobin (Hb) change and to tolerate early oral feeding. Conclusions: Increased clinical experience with FTS enables over 31% patients undergoing laparotomy to be safely discharged on day 2 without an increase in the readmission rate or morbidity.

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Effect of laxatives on gastrointestinal functional recovery in fast-track hysterectomy: a double-blind, placebo-controlled randomized study

Cited by 60 publications

References 18 publications

Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations

Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations

Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial

Early discharge after major gynaecological surgery: advantages of fast track surgery

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Effect of laxatives on gastrointestinal functional recovery in fast-track hysterectomy: a double-blind, placebo-controlled randomized study

Cited by 60 publications

References 18 publications

Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations

Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations

Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial

Early discharge after major gynaecological surgery: advantages of fast track surgery

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Product

Resources

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Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations

Guidelines for Perioperative Care in Elective Colonic Surgery: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations