Effect of laughter on salivary endocrinological stress marker chromogranin A

Toda, Masahiro; Kusakabe, Shinsuke; Nagasawa, Sumio; Kitamura, Kazuyuki; Morimoto, Kanehisa

doi:10.2220/biomedres.28.115

Cited by 38 publications

(21 citation statements)

References 14 publications

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“…In particular, chromogranin A (CgA), an acidic peptide stored by the adrenal medulla and coreleased with catechlamines, has become more accepted in studies of the endocrine acute stress response. Salivary CgA was found to increase rapidly during prolonged noise (45 ) and to decrease significantly in individuals being tested in a setting with humorous content (46 ). Accordingly, CgA in saliva could be a valuable parameter for measuring acute stress response under controlled study conditions.…”

Section: Researchmentioning

confidence: 97%

Current Status of Salivary Hormone Analysis

2008

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BACKGROUND: Saliva, which offers a noninvasive and stress-free alternative to plasma and serum, is a widely accepted sample source for analysis of steroids and also of certain amines and peptides. In recent years, numerous publications have described the use of salivary hormone analysis in many fields of clinical and basic research.CONTENT: This review provides an overview of the current applications of salivary hormone analysis. A description of the different modes of hormone entry into saliva is followed by a detailed description of analytical methods and approaches for reliable collection of saliva, including several interesting applications in diverse fields including psychiatry, stress research, clinical endocrinology, sports medicine, and veterinary medicine.

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Section: Researchmentioning

confidence: 97%

Current Status of Salivary Hormone Analysis

2008

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“…The CgA levels of the saliva samples collected before and after the stress task were analyzed. In addition, stress was measured subjectively before and immediately after the stress task using a ten-division visual analog scale (VAS) (27).…”

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confidence: 99%

Association between sleep bruxism and stress sensitivity in an experimental psychological stress task

et al. 2011

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The objective of this study was to examine the association between sleep bruxism and psychological stress. The subjects consisted of 76 volunteers, who were divided into those with and without bruxism according to the diagnostic criteria for sleep bruxism outlined by the American Academy of Sleep Medicine (AASM). Stress sensitivity was evaluated before and after an experimental stress task, which involved simple mathematical calculations. It was assessed objectively by measuring the subjects' salivary chromogranin A (CgA) levels and subjectively using a ten-division visual analog scale (VAS). Compared with those observed before the stress task, the mean salivary CgA levels of the non-bruxism group (n = 54) were not significantly increased after the stress task. Conversely, the mean salivary CgA levels of the bruxism group (n = 22) were significantly increased after the stress task (P < 0.01). The mean VAS scores of the groups without (n = 54) and with (n = 22) bruxism were significantly (P < 0.01) increased after the stress task compared with those observed before the stress task, but no differences were detected between the two groups in the stress task. These findings suggest that there is an association between sleep bruxism and psychological stress sensitivity.Oral habits such as bruxism are thought to affect temporomandibular disorders (TMD) and might have a relatively strong effect on the durability of prosthetic appliances (20,30). Bruxism, which is defined as clenching or grinding of the teeth, or a combination of both, is a diurnal or nocturnal parafunctional activity and has long been regarded as requiring treatment (5). It is thought that bruxism is associated with psychological stress (1,2,8,10,22). On the other hand, some studies did not find any association between bruxism and stress (15,19). The following reasons might explain this disagreement. In most of the above studies, diurnal bruxism and sleep bruxism were not distinguished from each other, and there were variations in the methods used to evaluate oral habits. In addition, differing definitions of stress and various methods for assessing stress were employed in these studies (17). Also, in these studies, stress was evaluated subjectively, such as by self-reporting, questionnaires, etc. Thus, the relationship between bruxism and stress is much more complex than previously imagined and involves many psychosocial factors (17). When humans are exposed to psychological stressors, the hypothalamic-pituitary-adrenal (HPA) axis and the sympathoadrenal medullary (SAM) system are activated (9,13,26). This results in changes of biomarkers, e.g., cortisol and/or chromogranin, etc., being secreted into the serum or saliva. Therefore, stress can be objectively evaluated by analyz-

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“…Its level has been reported to transiently increase in response to short-term stressors such as a calculation test [4], white noise [19], and a cognitive test [20]. However, a recent study showed a transient increase in the CgA level after watching a comic video [21]. This study also indicated that the elevation in CgA levels was remarkable in the subjects who experienced lower daily stress.…”

Section: Cgamentioning

confidence: 66%

Effect of the Relief From Chronic Stress During Graduation Examination on Salivary Biomarkers

Nomura

Ohira

Kamei

2009

Transactions of Japan Society of Kansei Engineering

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Abstract:The change in hormonal and immune state of university male students who were engaged in his graduation examination was investigated as a behavioral medicine study targeting on chronic stress. With regard to biomarkers of human hormonal and immune state, salivary secretory substances, Immunoglobulin A (IgA), Cortisol, Chromogranin (CgA), and dehydroepiandrosterone (DHEA), were assayed about a week before and 2 weeks after the day of oral defense of the graduation examination for 20 male students. As a result, the salivary immune substance, IgA, significantly decreased (p<0.001), while other biomarkers showed no significant change. In conclusion, it was suggested that IgA can be a promising candidate for a chronic stress marker.

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Effect of laughter on salivary endocrinological stress marker chromogranin A

Cited by 38 publications

References 14 publications

Current Status of Salivary Hormone Analysis

Current Status of Salivary Hormone Analysis

Association between sleep bruxism and stress sensitivity in an experimental psychological stress task

Effect of the Relief From Chronic Stress During Graduation Examination on Salivary Biomarkers

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