Effect of Laser Wavelengths on Drug Release with and without Gold Nanoshells and Magnetic Guidance on Uptake by Cancer Cells

Khosroshahi, Mohammad E.

doi:10.15406/jnmr.2017.06.00152

Cited by 3 publications

(1 citation statement)

References 45 publications

(53 reference statements)

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“…8,[11][12][13][14] Moreover, it was shown that laser-sensitive liposomes could be functionalized by the laser beam to enhance the release of the cargo leading to cancer cell death. 15,16 The mentioned data pointing to laser stimulation could eventually induce cell apoptosis. 17 As laser photomodulation and irradiation on cells is one of the most widespread applications of a laser in medicine and it is being frequently used in LDDSs for cancer patients, investigating its effect on liposomal drug release is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Effect of a Low-Level Laser on Liposomal Doxorubicin Efficacy in a Melanoma Cell Line

et al. 2021

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Introduction: The cytotoxicity of chemotherapy drugs is a significant challenge in the way of surmounting cancer. Liposomal drug delivery has proven to be efficacious in increasing the function of the drugs. Its potential to accumulate drugs in the target site and enhance the efficiency of anti-cancer agents with lower doses hinders their cytotoxicity on normal healthy cells. Since the release of drugs from liposomes is not generally on a controlled basis, several studies have suggested that external stimuli including lasers could be used to induce controlled release and boost the efficiency of liposomal drug delivery systems (LDDSs). Methods: The A375 cancer cell line was used and exposed to the liposomes containing doxorubicin in the presence of a low-level laser beam to investigate its effect on the liposomal stimuli-responsiveness release and its toxicity on cancer cells. So as to achieve that goal, Annexin V/PI was employed to analyze the number of cells that underwent apoptosis and necrosis. Results: Here, we report the effect of laser irradiation on LDDSs. According to the results obtained from the annexin V/PI assay, the pattern of viability status has shifted, so that the number of pre-apoptotic cells treated with liposomal doxorubicin and a laser beam was more than that of cells treated with only liposomal doxorubicin. Conclusion: The use of stimuli-responsive LDDSs, in this case, laser-responsive, has led to favorable circumstances in the treatment of cancer, offering enhanced cancer cell cytotoxicity.

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Section: Introductionmentioning

confidence: 99%

Effect of a Low-Level Laser on Liposomal Doxorubicin Efficacy in a Melanoma Cell Line

et al. 2021

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Thermally Activated Noble Metal Nanoparticles Incorporated in Electrospun Fiber-based Drug Delivery Systems

Fazio

Ridolfo

Neri

2019

CNM

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Background: Nanosystems based on PEG-PLGA copolymer have attracted increasing interest in several biomedicine fields, due to their unique properties. Commonly, PEG-PLGA copolymer was used to formulate nanoparticles (NPs) for drug delivery applications. Only recently, the engineering of polymeric nanofibrous membrane able to be use like drug nanocarrier was investigated. Objective: The goal of this work is the development of two new drug delivery systems based on PEGylated-PLGA nanofibrous scaffolds, obtained by electrospinning deposition, simultaneous loaded with: i) silibinin, a therapeutic agent, ii) Au/Ag and iii) non-toxic Fe2O3 magnetic nanoparticles. Another interest aspect of the present work regards how the morphological structure can influence the drug release which has been fine-tuned by two external stimuli: a light source and a magnetic field. Methods: Noble metal nanocolloids were prepared in water by the pulsed laser ablation technique. The PEG-PLGA@Au/Ag-SLB added with Fe2O3-PVA nanofibers were fabricated by the electrospinning deposition method. Results: The use of “Surface Plasmon Resonance”-mediated localized photothermal effect, determined by the nanoparticles resonant absorption of visible radiation, allows to these systems to be able to employ for photothermal drug delivery therapies in proximity of tumor cells. All data obtained about the fiber scaffolds are compared to NPs based on the same PEG-PLGA copolymer, loaded with silibinin, Fe2O3 and Au/Ag nanoparticles alternatively. Nanofibers respects to NPs, showed interesting sustained responsive silibinin release for at least 60 h, without the burst effect. A diffusion-based theoretical model approach allowed to precisely describe the release mechanism. Conclusion: The effective and controlled silibilin drug release, upon application of either light irradiation or magnetic field for a definite time interval, has been demonstrated. Under the light stimulus, the fiber-shaped nanosystem reached a cumulative drug release value as high as 70% in the long time. On the overall, the information obtained could be useful to design suitable “on demand” nanocomposites in view of a therapeutic treatments protocol that requires a fast pharmacological action.

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Measurements of Pulsed 532 nm Laser Breakdown Spectroscopy of Synthesized Magnetite Nanoferrofluid

Khosroshahi¹,

Tajabadi²

2018

WJNSE

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We describe the results of 532 nm pulse laser-induced breakdown spectroscopy (LIBS) of two samples of magnetite nanoparticles (SPIONs) nanoferrofluid synthesized at room (S1) and elevated temperatures (S2) and at three different laser energy levels and pulse frequency. The size of magnetite nanoparticles, size distribution, magnetic crystalline phase and magnetization were analyzed and measured using transmission electron microscopy (TEM), X-ray diffraction spectroscopy (XRD) and vibrating sample magnetometry (VSM). The SPIONs showed a distribution between 4-22 nm with a peak about 12 nm and saturation magnetization of about 65 emu/g. The Saha-Boltzmann analysis of spectra for medium energy level (1050 mJ) yields plasma temperatures of (3881 ± 200) K and (26,047 ± 200) K for Fe I and OV as the lowest and highest temperatures respectively. A range of corresponding electron density (Ne −) of (0.47-6.80) × 10 20 , (0.58-8.30) × 10 20 and (0.69-9.96) × 10 20 cm −3 were determined at 860, 1050 and 1260 mJ respectively using the estimated CCD pictures. The results confirmed a higher elements ratio for S1 than S2 and the signal intensity indicated a non-linear behaviour as a function of pulse frequency with the maximum ratio value at 3 Hz. At higher frequency of 6 Hz no such turning point was observed. The highest and lowest temperatures corresponded to Fe I and OV respectively. The LIBS technique can be utilized to study, characterize and determine the elements ratio required in most applications involving the synthesizing process.

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Effect of Laser Wavelengths on Drug Release with and without Gold Nanoshells and Magnetic Guidance on Uptake by Cancer Cells

Cited by 3 publications

References 45 publications

Effect of a Low-Level Laser on Liposomal Doxorubicin Efficacy in a Melanoma Cell Line

Effect of a Low-Level Laser on Liposomal Doxorubicin Efficacy in a Melanoma Cell Line

Thermally Activated Noble Metal Nanoparticles Incorporated in Electrospun Fiber-based Drug Delivery Systems

Measurements of Pulsed 532 nm Laser Breakdown Spectroscopy of Synthesized Magnetite Nanoferrofluid

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