Since a photon carries both energy and momentum, when it interacts with a particle, photon-particle energy and momentum transfer occur, resulting in mechanical forces acting on the particle. In this paper we report our theoretical study on the use of a laser beam to manipulate and control the flow of nanofluids in a micro-channel. We calculate the velocity induced by a laser beam for TiO 2 , Fe 2 O 3 , Al 2 O 3 MgO, and SiO 2 nanoparticles with water as the base fluid. The particle diameter is 50 nm and the laser beam is a 4 W continuous beam of 6 mm diameter and 532 nm wavelength. The results indicate that, as the particle moves, a significant volume of the surrounding water (up to about 8 particle diameters away from the particle surface) is disturbed and dragged along with the moving particle. The results also show the effect of the particle refractive index on the particle velocity and the induced volume flow rate. The velocity and the volume flowrate induced by the TiO 2 nanoparticle (refractive index n = 2.82) are about 0.552 mm/s and 9.86 fL, respectively, while those induced by SiO 2 (n = 1.46) are only about 7.569 µm/s and 0.135, respectively.