Effect of large doses of ascorbic acid on the mixed function oxidase system in guinea pig liver

Sutton, Judith L.; Basu, Tapan K.; Dickerson, J. W. T.

doi:10.1016/0006-2952(82)90385-9

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…Vitamin C deficiency in the guinea pig depresses monooxygenäse content and acitivty (201)(202)(203); however, excess vitamin C will not increase the activity but may even exert a depressive action (204,205). Whether such depression of monooxygenäse activity is involved in the protection by vitamin C against carcinogens has not yet been directly studied.…”

Section: Inhibition Of Nitrosation: a Case For Vitamins C And Ementioning

confidence: 98%

The dual role of antioxidants in the modification of chemical carcinogenesis

Kahl¹

1986

Environmental Carcinogenesis Reviews

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Section: Inhibition Of Nitrosation: a Case For Vitamins C And Ementioning

confidence: 98%

The dual role of antioxidants in the modification of chemical carcinogenesis

Kahl¹

1986

Environmental Carcinogenesis Reviews

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“…Subsequent studies indicated that also in volunteers altering the protein content impacted on the metabolism of drugs [4]. Basu then turned his attention to micronutrients, and demonstrated that large doses of ascorbic acid impaired both the 4-hydroxylation of biphenyl and the N-demethylation of ethylmorphine in guinea pigs [5]. Thus these studies revealed the potential of the diet to influence the metabolism of drugs and chemical carcinogens, altering the balance of activation/ deactivation [6].…”

Section: Isothiocyanate Interventionmentioning

confidence: 99%

“…Many of these phytochemicals have been shown to modulate the metabolism of xenobiotics, including medicinal drugs and chemical carcinogens, even following exposure to dietary levels. In seminal studies that commenced in the 1970s it was demonstrated that the feeding of volunteers with diets supplemented with cruciferous vegetables, such as cabbage and Brussels sprouts, modulated the metabolism of drugs like phenacetin and paracetamol [5,9]. In subsequent studies, human volunteers consuming daily 500 g of lightly cooked broccoli for 10-12 days exhibited elevated metabolism of caffeine, presumably by up-regulating CYP1A2, a liverspecific cytochrome P450 enzyme that functions as the principal catalyst of the oxidation of caffeine [10,11].Consumption of watercress (100g/day) for only a week suppressed the metabolism of chlorzoxazone in human volunteers, which is catalysed by CYP2E1 [12].…”

Section: Deactivationmentioning

confidence: 99%

Isothiocyanates: A Chemical Class of Potential Nutraceuticals

Ioannides¹,

Hanlon²,

Konsue³

2010

TONUTRAJ

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Abstract:Isothiocyanates comprise the most promising class of chemopreventive phytochemicals. They are encountered at substantial amounts in cruciferous vegetables where they exist in the form of glucosinolates. Epidemiological studies have linked consumption of isothiocyanates to low cancer incidence at a number of sites. Furthermore, laboratory studies in animal models of cancer have established that various isothiocyanates can effectively antagonise the carcinogenicity of chemicals. A principal mechanism of action of these chemicals is to modulate the metabolism of chemical carcinogens so as to favour their metabolic detoxification. In this mini review we discuss the ability of isothiocyanates to influence carcinogen-metabolising enzyme systems, such as cytochromes P450 and conjugation systems, at dietary levels of exposure.

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“…and 3) Investigation of the thiamin antagonistic effect of widely used cytotoxic agent 5-fluorouraci on malignant diseases [45][46][47]. Dr. Basu's research on various aspects of ascorbic acid is well known, in particular, his extensive reports against its Mega dose usage have been considered to be fundamental and have received much attention [39,44,[48][49][50]. Dr. Basu's recent research investigation on diabetes is another major break through in the contemporary nutritional research realm.…”

Section: Dr T K Basu's Research Profile and Our Common Research Inmentioning

confidence: 99%

Genotype X Environment Interactions and Its Impact on Use of Medicinal Plants

Acharya¹,

Basu²,

Banik³

et al. 2010

TONUTRAJ

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There is a paradigm shift from cure to prevention when it comes to human health. We want to live a healthy life and prevent sickness using substances other than pharmaceuticals. The plant-based nutraceutical products or Natural Health Products (NHPs) as they are some times referred to are the most important groups that have the potential to fit the bill. However, these products are sold without proper science based information in spite of the fact that most researchers acknowledge the need for such information. Evidence-based scientific studies to support health and nutraceutical claims related to the use of medicinal plants and their extracts have to be undertaken. It is only through critical research efforts that we can provide strong endorsements for medicinal plant use and ensure consumer confidence in the industry. Much of the research published on the medicinal value of plants does not take into account variability generated from genetic differences among plants and their interaction with the environment. Research should be directed towards properly identifying plants with known medicinal properties which have been grown in environments that are conducive to consistent production of the active agents attributed to the plants. Production of dependable medicinal plant products can only be attained if we pay close attention to these research-based principles. This article was written with main goals: 1) To discuss the above points in greater detail with examples; and 2) to highlight life time accomplishments and significant contributions of a well respected nutritionist Dr. T. K. Basu and his collaboration in development of fenugreek as a NHP. We believe that collaboration among clinical and agricultural researchers is essential to make the NHPs utilized to its potential and the plants (parts such as seed, foliage or roots) should be developed to the extent that they can be used directly to take advantage of the synergistic effect of the chemical constituents.

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Effect of large doses of ascorbic acid on the mixed function oxidase system in guinea pig liver

Cited by 10 publications

References 22 publications

The dual role of antioxidants in the modification of chemical carcinogenesis

The dual role of antioxidants in the modification of chemical carcinogenesis

Isothiocyanates: A Chemical Class of Potential Nutraceuticals

Genotype X Environment Interactions and Its Impact on Use of Medicinal Plants

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