Effect of Laparoscopic Sleeve Gastrectomy vs. OAGB on Thyroid Function Tests in Patients with Morbid Obesity and Subclinical or Clinical Hypothyroidism

Najjari, Khosrow; Talebpour, Mohammad; Mahmoudabadi, Hossein Zabihi; Elyasinia, Fezzeh; Abolhasani, Maryam; Ashrafi, Amir; Maralani, Mehran Sohrabi; Mehdinavaz, Abdolreza; Kor, Farhad

doi:10.1007/s11695-021-05646-w

Cited by 1 publication

(3 citation statements)

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“…We observed a significant decrease in TSH levels in our cohort. These results were consistent with the results of previous studies, which are summarized in Table 3 [ 28 – 34 ]. However, inconsistent findings regarding FT3 and FT4 levels have been reported in previous studies.…”

Section: Discussionsupporting

confidence: 93%

“…Published studies have reported inconsistent results. Although Chen Y et al, Chen Xi et al, and Karaman et al reported significant decreases in FT3 levels, Yang et al and Aykota et al reported non-significant increases [ 28 , 30 – 32 , 34 ]. In addition, Aykota et al and Chen Xi et al reported significant increases in FT4 levels, in agreement with our findings, although other authors found no significant difference [ 29 – 34 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although Chen Y et al, Chen Xi et al, and Karaman et al reported significant decreases in FT3 levels, Yang et al and Aykota et al reported non-significant increases [ 28 , 30 – 32 , 34 ]. In addition, Aykota et al and Chen Xi et al reported significant increases in FT4 levels, in agreement with our findings, although other authors found no significant difference [ 29 – 34 ]. These discrepancies can be related to various factors, including variations in surgical techniques (such as bougie size, distance to the pylorus, and the size of the remaining gastric fundus), BMI changes, individual fatty tissue alterations, and other unknown hormonal changes.…”

Section: Discussionmentioning

confidence: 99%

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Laparoscopic Sleeve Gastrectomy: Impact on Body Mass Index and Thyroid Hormones in Euthyroid Obese Patients

Buk,

Ocak,

Uyanik

et al. 2023

Med Sci Monit

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Background Obesity is still a major global public health problem and its incidence is increasing. Obesity leads to deterioration in thyroid functions. Even when they are within normal ranges, high normal levels of thyroid-stimulating hormone (TSH) increase morbidity and mortality. This study aimed to evaluate the body mass index (BMI) and TSH levels in 300 euthyroid patients with obesity before and after laparoscopic sleeve gastrectomy (LSG). Material/Methods A total of 300 euthyroid patients who underwent LSG between 2019 and 2021 were included in the study. Body mass index (BMI), thyroid-stimulating hormone (TSH), and free triiodothyronine (FT) 3 and tetraiodothyronine (FT4) levels were recorded before surgery and at 6 and 12 months after surgery and subsequently analyzed. Results Mean BMI values were significantly lower at 6 and 12 months after surgery ( P <0.001). There was a significant difference between mean TSH and FT4 levels before surgery and those at 6 and 12 months after surgery ( P <0.001). However, mean FT3 levels remained unchanged 1 year after surgery ( P =0.005). Conclusions LSG is not only effective in terms of weight loss, but also exhibits improving effects on thyroid hormone homeostasis in obese patients and provides protection against further adverse effects of TSH.

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Section: Discussionsupporting

confidence: 93%