Effect of Laparoscopic Sleeve Gastrectomy (LSG) Surgery on Weight Reduction and Serum Visfatin, Ghrelin and Leptin Levels in Morbidly Obese Subjects

Abstract

Aim: this study aimed to investigate how Laparoscopic sleeve gastrectomy (LSG) Surgery affect the weight reduction and level of serum adipokines (Visfatin , Ghrelin and Leptin) in Morbidly Obese Subjects because of the Conflicting results that obtained from previous studies regarding the changes of adipokines following sleeve operation and weight reduction. Method: 20 Iraqi severely obese patients (12 females and 8 males), Mean ±SD of aged are 34.45±9.47, and 40 healthy lean controls (24 females and 16 males) Mean ±SD of aged are 33.90±9.31were studied. Anthropometric parameters and biochemical parameters (insulin resistant IR) as well as visfatin, ghrelin and leptin were analyzed before and 6 weeks after the operation. Results: after surgery Anthropometric indices (BMI) decreased significantly. The reduction of visfatin and the elevation of ghrelin were statistically not significant, whereas leptin level decrease significantly and insulin resistant (IR) decrease not significantly. moreover, there is a significant positive correlation between the change of serum leptin and (BMI)and visfatin correlated positively with insulin resistant (HOMA-IR).Conclusions: sleeve Gastrectomy resulted in significant decrease in the (BMI), decreased serum visfatin, insulin resistant and increased ghrelin levels statistically not significant, while significant decrease in leptin level. Further studies with different design are suggested to clarify these changes.