The saltwater intrusion occurs in many coastal areas worldwide and has become a serious menace to freshwater quality. In the Pearl River estuary, saltwater intrusion has threatened the water supply for residential, agricultural, and industrial uses in the past decades, and resulted in economic losses. In this study, the observed saltwater intrusion records of 10 years (2012~2021) at 9 stations in Modaomen waterway, the largest inlet of the Pearl River estuary, were compiled and analyzed with the reported sea level heights and river discharge volumes during the same period. Along the Modaomen waterway, the annual saltwater intrusion days have inversely correlated exponential relationship (R 2 = 0.97) with distance away from the Pearl River estuary mouth. The results from a multiple linear regression show that the observed annual saltwater intrusion days near the main Pearl River estuary mouth could be quantitatively explained by the combination of river discharge volumes and sea level rise values. Every 1 mm increase of annual sea level rise, would led to an extended saltwater intrusion for 0.410±0.116 day in the same year near the main estuary mouth of the Pearl River. This work presents an example to investigate the sea level rise impacts on saltwater intrusion with annually compiled observed data and from a time-change perspective.