Effect of lactose hydrolysis on calcium absorption during duodenal milk perfusion

Birlouez‐Aragon, Inès

doi:10.1051/rnd:19880903

Cited by 15 publications

(7 citation statements)

References 19 publications

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“…These findings indicate that hydrolysis of lactose in the intestine is a prerequisite for increased Ca absorption. In keeping with this, Birlouez-Aragon (1988) showed that after milk consumption lactose-intolerant subjects absorb less Ca than lactose-tolerant subjects. Furthermore, compared with normal milk, lactase-treated milk enhanced Ca absorption in lactose-intolerant subjects but had no effect in lactose-tolerant subjects (Birlouez-Aragon, 1988).…”

Section: Discussionsupporting

confidence: 52%

Urinary excretion of magnesium and calcium as an index of absorption is not affected by lactose intake in healthy adults

Brink¹,

Beresteijn²,

Dekker³

et al. 1993

Br J Nutr

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The effect of lactose on the urinary excretion of Mg and Ca, as an index of absorption, was studied in a double-blind, crossover study during three l-week periods. Twenty-four healthy, lactose-tolerant, adult volunteers maintained their habitual diets with the exception that all lactose-containing dairy products in the diet were replaced by 600 g/d of three specially prepared dairy products. These products were based on either lactose-enriched cow's milk or lactose-enriched, lactase (EC 3.2.1 .23)-treated cow's milk, with or without added Mg, and were given in turn during 1 week. Lactose intake was increased by 127 mmol/d (46 g/d) while taking the lactose-enriched products. While taking the Mg-enriched products, Mg intake was increased by 2.8 mmol/d (69 mg/d) which was equivalent to 17 % of the habitual Mg intake. Apart from the lactose and Mg intake, nutrient intake was comparable during the three dietary periods. Urinary excretions of Mg and Ca were used as indicators for their absorption. Mg supplementation significantly increased urinary M g excretion by 0.97 mmol/d (equivalent to an increase of 18%, P < 0.001), indicating that urinary Mg excretion is a valid indicator for intestinal Mg absorption. Hydrolysis of lactose did not affect urinary excretion of Mg and Ca, which implies that lactose intake does not affect the absorption of Mg and Ca in healthy adults.

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Section: Discussionsupporting

confidence: 52%

Urinary excretion of magnesium and calcium as an index of absorption is not affected by lactose intake in healthy adults

Brink¹,

Beresteijn²,

Dekker³

et al. 1993

Br J Nutr

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“…Two‐way transport systems in the intestinal absorption of calcium are considered: passive transport in the duodenum to ileum and diffusion transport in the jejunum. There are various hypotheses concerning the calcium absorption‐promoting action of lactose: It has been reported that lactose increased calcium permeability in small intestinal villi (18), an increase in intestinal lactic acid bacteria decreased intestinal pH and promoted calcium absorption (32, 33), and lactose formed chelates or complexes (34), but many points remain unclear regarding the mechanisms. Previously, we reported that intestinal alkaline phosphatase activity in the rat intestine was markedly enhanced after 21 days of being fed a 10% lactose diet, and lactose is one of the factors responsible for intestinal alkaline phosphatase activity (35).…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Lactose on Long‐term High‐fat‐diet‐induced Obesity in Rats

Goseki‐Sone

Maruyama

Sogabe

et al. 2007

Obesity

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GOSEKI-SONE, MASAE, RIEKO MARUYAMA, NATSUKO SOGABE, AND TAKAYUKI HOSOI. Effects of dietary lactose on long-term high-fat-diet-induced obesity in rats. Obesity. 2007;15:2605-2613. Objective: In this study, we examined the effects of lactose on long-term high-fat-diet-induced obesity in rats. Research Methods and Procedures:A total of 112 Sprague-Dawley strain female rats (6 weeks old) were divided into four groups: a basic control diet group (Cont), 10% lactose diet group (Lac), high-fat diet group (Fat), and high-fat with 10% lactose diet group (FatϩLac). After 0, 7, 14, and 84 days from starting the experimental diet, the animals were fasted overnight and killed by bleeding from the abdominal aorta under anesthesia (n ϭ 8 or 9/group). Results: After 84 days, the addition of lactose to the high-fat diet decreased the final body weight, body weight gain, fat accumulation, and the levels of serum leptin, serum triglycerides, and serum glucose significantly (p Ͻ 0.05). Although there was no significant difference in the levels of serum calcium and phosphorus between the Fat and FatϩLac groups, lumbar vertebral bone mineral density was significantly higher in the FatϩLac group than in the Cont group on Day 82. Interestingly, the level of serum 1␣, 25-dihydroxyvitamin D 3 in the FatϩLac group on Day 84 was reduced by 74% compared with the Fat group (p Ͻ 0.01), while there was no significant difference in serum parathyroid hormone levels between the Fat and FatϩLac groups. Discussion: This is the first study to suggest that the addition of lactose to a long-term high-fat diet may regulate not only calcium metabolism but also fat deposition. Further studies on the mechanism of dietary lactose in the regulation of adiposity would provide valuable data for the prevention of long-term high-fat-diet-induced obesity.

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“…Lactose stimulates the intestinal absorption of calcium in the infant because in these subjects, the enzyme β-galactosidase (which hydrolyses lactose into galactose and glucose) is highly expressed. Some studies in fact demonstrated that β-galactosidase-deficient subjects absorbed less calcium than β-galactosidase-normal subjects because are the hydrolytic products of β-galactosidase (glucose and galactose) that promote the calcium absorption [31,32]. Therefore, even after weaning, if a balanced diet is followed, donkey milk favors bones mineralization.…”

Section: Donkey Milk and Its Affinity With Human Milkmentioning

confidence: 99%

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

et al. 2017

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Donkey milk could be considered a good and safer alternative, compared to other types of milk, for infants affected by cow's milk protein allergy, when breastfeeding is not possible. Interestingly, donkey milk has low allergenicity, mainly due to the low total casein amount, and the content of some whey proteins that act as bioactive peptides. The amount of lysozyme, an antibacterial agent, is 1.0 g/L, similar to human milk. Lactoferrin content is 0.08 g/L, with this protein being involved in the regulation of iron homoeostasis, anti-microbial and anti-viral functions, and protection against cancer development. Lactoperoxidase, another protein with antibacterial function, is present in donkey milk, but in very low quantities (0.11 mg/L). β-lactoglobulin content in donkey milk is 3.75 g/L-this protein is able to bind and transport several hydrophobic molecules. Donkey milk's α-lactalbumin concentration is 1.8 g/L, very close to that of human milk. α-lactalbumin shows antiviral, antitumor, and anti-stress properties. Therefore, donkey milk can be considered as a set of nutraceuticals properties and a beverage suitable, not only for the growing infants, but for all ages, especially for convalescents and for the elderly.

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Effect of lactose hydrolysis on calcium absorption during duodenal milk perfusion

Cited by 15 publications

References 19 publications

Urinary excretion of magnesium and calcium as an index of absorption is not affected by lactose intake in healthy adults

Urinary excretion of magnesium and calcium as an index of absorption is not affected by lactose intake in healthy adults

Effects of Dietary Lactose on Long‐term High‐fat‐diet‐induced Obesity in Rats

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

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