Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor

Yeganegi, Maryam; Watson, Carole; Martins, Andrew J.; Kim, Sung O.; Reid, Gregor; Challis, John; Bocking, Alan D.

doi:10.1016/j.ajog.2008.12.032

Cited by 90 publications

(70 citation statements)

References 37 publications

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“…For example, there is a strong association between elective preterm delivery (usually undertaken because of growth restriction or preeclampsia) and ischemic heart disease. 57 It should be noted that probiotics have not been proven clinically to reduce the risk of these complications in pregnancy, but as presented in Table I, 46,[58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] there are a number of attributes of these organisms that could play a role.…”

Section: Environmental Influences On Pregnancymentioning

confidence: 99%

The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome

Reid¹,

Bisanz²,

Monachese³

et al. 2013

American J Rep Immunol

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ProblemMedical problems of most importance to reproductive health of women differ to some extent between the developed world and resource‐disadvantaged countries. Nevertheless, many share a common link in microbial involvement.Method of studyA review of the peer‐reviewed literature on microbiota, probiotics, and reproductive health.ResultsIndigenous and probiotic lactobacilli express properties antagonistic to pathogens, but complementary to host immunity. These organisms are associated with conception, reducing the risk of infection, as well as potentially lowering the risk of a number of complications of pregnancy that otherwise lead to maternal and infant mortality and morbidity.ConclusionsThe ability to manipulate the microbiome and to improve immunity through probiotics holds much promise. The lack of improvements over the past 40 years in managing urogenital infections in women is incomprehensible. Support for innovative diagnostic and treatment options is needed, including testing and implementing probiotic therapies, especially for women with poor access to healthcare and good nutrition.

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Section: Environmental Influences On Pregnancymentioning

confidence: 99%

The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome

Reid¹,

Bisanz²,

Monachese³

et al. 2013

American J Rep Immunol

Self Cite

View full text Add to dashboard Cite

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“…Finally, probiotics may stimulate the immune system by producing anti-inflammatory cytokines. It has been reported that L. rhamnosus GR-1 decreases pro-inflammatory, while at the same time increases anti-inflammatory cytokines in human trophoblasts [36] . Several other studies have also reported that the same lactobacillus strain upregulates the anti-inflammatory response following intravaginal application [37,38] .…”

Section: Discussionmentioning

confidence: 95%

Vaginal Probiotic Administration in the Management of Preterm Premature Rupture of Membranes

Karambelas¹

2016

Fetal Diagn Ther

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Objective: To examine the influence of vaginal probiotic administration as an adjunct to standard antibiotic treatment on perinatal outcome in women with preterm premature rupture of membranes (PPROM). Materials and Methods: This was a prospective randomized trial of cases with PPROM (24-34 weeks) that were admitted to our department between 2011 and 2015. Forty-nine cases received vaginal probiotics for 10 days in combination with antibiotic prophylaxis and were compared to 57 others that received only antibiotics for the same time period. Results: The mean gestational age at birth (35.49 vs. 32.53 weeks), the mean duration of the latency period (5.60 vs. 2.48 weeks), and the mean birth weight (2,439.08 vs. 2,004.81 g) were significantly higher in the study group in comparison to the controls. Moreover, the neonates of the study group had a lower chance to enter the neonatal intensive care unit or the neonatal special care unit, shorter total hospitalization time, and lower need for oxygen administration and mechanical ventilation, as well as lower length of oxygen administration. Conclusions: Vaginal probiotics as an adjunct to antibiotic prophylaxis in women with PPROM prolonged the latency period and improved the perinatal outcome.

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“…Supernatants of the probiotic Lactobacillus rhamnosus added to trophoblast cultures pretreated with LPS reduces TNF-α production and increases IL-10 production, compared to controls [73]. Supernatants from L. rhamnosus partially inhibit the LPS-induced expression of the prostaglandin-synthesizing enzyme, PTGS2, in trophoblasts from mouse placentas of male but not female offspring [73].…”

Section: Lessons From Animal Models Of Infection-induced Preterm Birthmentioning

confidence: 97%

Toll-like Receptors in Pregnancy Disorders and Placental Dysfunction

Riley

Nelson

2009

Clinic Rev Allerg Immunol

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The Toll receptor was originally identified as a regulator of embryogenesis in Drosophila. Toll-like receptors (TLRs) in mammals recognize infectious agents and other danger signals. Activation of TLRs on trophoblast influences immune cell recruitment, cytokine secretion, and decidual responses to invading pathogens during pregnancy. Importantly, biological effects of TLR signal transduction at multiple maternal-fetal interfaces may contribute to several pregnancy pathologies associated with placental dysfunction, including pre-eclampsia, intrauterine growth restriction, and preterm labor. We herein discuss mechanisms by which TLRs regulate the maternal immune response during normal and abnormal gestation, and we highlight recent data that assign a role to TLRs in the pathophysiology of selected pregnancy-associated complications.

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Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor

Cited by 90 publications

References 37 publications

The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome

The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome

Vaginal Probiotic Administration in the Management of Preterm Premature Rupture of Membranes

Toll-like Receptors in Pregnancy Disorders and Placental Dysfunction

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