Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: A double blind, randomized, controlled trial

Vrese, Michael de; Winkler, Petra; Rautenberg, Peter; Harder, Timm C.; Noah, Christian; Laue, Christiane; Ott, Stephan; Hampe, Jochen; Schreiber, Stefan; Heller, Knut J.; Schrezenmeir, Jürgen

doi:10.1016/j.clnu.2005.02.006

Cited by 219 publications

(181 citation statements)

References 25 publications

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“…For two winter/spring seasons, 479 adults were daily treated with vitamins and minerals enriched or not with probiotics. The results indicate a reduction in the duration of episodes of common cold of at least 2 days and a decrease in the severity of symptoms among subjects receiving probiotics if compared to the randomized placebo-control group [92]. Similar conclusions were obtained in a study that assessed the effect of long-term intake of probiotics on the same pathology [93].…”

Section: Adultssupporting

confidence: 73%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

232

131

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a b s t r a c tThe intestinal microbiota is an ecosystem formed by a variety of ecological niches, made of several bacterial species and a very large amount of strains. The microbiota is in close contact with the intestinal mucosa or epithelial interface which is, after the respiratory area, the largest surface of the body, occupying approximately 250-400 m 2 . The physiological activities of the microbiota are manifold and are just being unraveled. Based on the observations of the multiple roles played by the microbiota in health and disease, the notion of modifying it with appropriate formulations, i.e. probiotics, is being tested in several settings.This review summarizes the current knowledge on probiotics and discusses both limitations and acquired evidence to support their use in preventive and therapeutic medicine.

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Section: Adultssupporting

confidence: 73%

Probiotics and health: An evidence-based review

Aureli

Capurso

Castellazzi

et al. 2011

Pharmacological Research

232

131

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“…Multiple phylogenetically distinct species significantly enriched in these animals were not enriched in L. johnsonii-supplemented animals, implicating these species in enhanced airway protection, and indicating that GI species that contribute to airway protection originate from environmental sources. Indeed, previous research has demonstrated that, although oral supplementation of animals with a single species can elicit airway protection (25,26), several studies that supplemented with a phylogenetically distinct multispecies consortia have demonstrated improved efficacy (23,27). As indicated from our predictive metagenomic analyses, protection is likely a combinatorial effect based on multiple pathways and resulting microbial products encoded by these cocolonizers resulting in presentation of a specific suite of microbial ligands and a distinct profile of microbial metabolites to the innate and acquired components of the host immune system.…”

Section: Discussionmentioning

confidence: 99%

House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection

Fujimura¹,

Demoor

Rauch³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

376

321

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Significance Early-life exposure to dogs is protective against allergic disease development, and dog ownership is associated with a distinct milieu of house dust microbial exposures. Here, we show that mice exposed to dog-associated house dust are protected against airway allergen challenge. These animals exhibit reduced Th2 cytokine production, fewer activated T cells, and a distinct gut microbiome composition, highly enriched for Lactobacillus johnsonii , which itself can confer airway protection when orally supplemented as a single species. This study supports the possibility that host–environment interactions that govern allergic or infectious airway disease may be mediated, at least in part, by the impact of environmental exposures on the gastrointestinal microbiome composition and, by extension, its impact on the host immune response.

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“…Numerous studies support the beneficial effect of living microbial food supplements in health and disease (Marcos et al, 2004;Valeur et al, 2004;De Vrese et al, 2005;Viljanen et al, 2005;Weston et al, 2005;Ewaschuk and Dieleman, 2006;Olivares et al, 2006;Suomalainen et al, 2006). The functional properties of probiotics are strainspecific.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults

Friedrich²,

et al. 2007

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Objective: It was determined whether a combination of Lactobacillus acidophilus (L. acidophilus) 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 (B. lactis 420) affect the faecal microbiota as well as immunological parameters and blood lipids in healthy adults. Design: A placebo-controlled, double-blinded, randomized crossover trial was conducted. Subjects: Twenty-six healthy volunteers (mean age 25 years) were recruited by advertising in academical buildings. All of them completed the study. Methods: After 3-week run-in period, half of the volunteers consumed 300 g/day of yoghurt supplement containing probiotic strains L. acidophilus 74-2 and B. lactis 420, and the other half received the placebo product for a period of 5 weeks. The two groups were crossed during the following 5-week period. Blood and faecal samples were collected at the end of each period. The faecal content of probiotic bacteria, faecal short-chain fatty acids (SCFA), serum lipids and plasma immune system biomarkers were evaluated. Results: Faecal proportions of L. acidophilus and of B. lactis increased significantly from 0.02 to 0.19 and 0.4 to 1.4% (Po0.05), respectively. Percentages of granulocytes and monocytes showing phagocytic activity were significantly elevated from 92 to 95% during probiotic intervention, whereas their oxidative burst activity and specific immune parameters remained unaffected. Fecal SCFA and serum cholesterol levels were not influenced by the probiotics. However, serum concentrations of triacylglyceroles decreased significantly by 11.6% (Po0.05) in the probiotic supplementation period. Conclusions: L. acidophilus and B. lactis were recovered in faeces in significantly elevated numbers after supplementation. They are able to modulate unspecific cellular immune response indicated by the increased phagocytic activity.

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Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. bifidum MF 20/5 on common cold episodes: A double blind, randomized, controlled trial

Cited by 219 publications

References 25 publications

Probiotics and health: An evidence-based review

Probiotics and health: An evidence-based review

House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults

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