Effect of Lactobacillus casei on the Production of Pro-Inflammatory Markers in Streptozotocin-Induced Diabetic Rats

Zarfeshani, Aida; Khaza’ai, Huzwah; Ali, Razana Mohd; Hambali, Zarida; Wahle, Klaus W.J.; Mutalib, Mohd Sokhini Abd

doi:10.1007/s12602-011-9080-9

Cited by 22 publications

(22 citation statements)

References 48 publications

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“…Davari et al (2013) and Lin et al (2014) reported a significant de crease in glucose levels inanimals receiving a probiotic mix containing Lactobacillusacidophilus, Bifidobacterium lactis and Lactobacillusfermentum and Lactobacillus reuteri, respectively,compared with diabetic controls, as was seen in this study. Tabuchi et al (2003) and Yadav et al (2008) observed animprovement in glucose tolerance following Lactobacillusrhamnosus GG, L. acidophilus and Lactobacillus caseisupplementation, whereas Zarfeshani et al (2011) foundno significant differences in blood glucose levels followingL. casei supplementation.…”

Section: Discussionmentioning

confidence: 95%

Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

Marques

Patterson

Wall

et al. 2016

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The aim of this study was to investigate if dietary administration of γ-am inobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert protective effects against the development of diabetes in streptozotocin (STZ)-induced diabetic Sprague Dawley rats. In a first experiment, healthy rats were divided in 3 groups (n=10/group) receiving placebo, 2.6 mg/kg body weight (bw) pure GABA or L. brevis DPC 6108 (-'109 microorganisms). In a second experiment, rats (n=15/group) were randomised to five groups and four of these received an injection of STZ to induce type 1 diabetes. Diabetic and nondiabetic controls received placebo [4% (w/v) yeast extract in dH2O], while the other three diabetic groups received one of the following dietary supplements: 2.6 mg/kg bw GABA (low GABA), 200 mg/kg bw GABA (high GABA) or -'109 L. brevis DPC 6108. L. brevis DPC 6108 supplementation was associated with increased serum insulin levels (P<0.05), but did not alter other metabolic markers in healthy rats. Diabetes induced by STZ injection decreased body weight (P<0.05), increased intestinal length (P<0.05) and stimulated water and food intake. Insulin was decreased (P<0.05), whereas glucose was increased (P<0.001) in all diabetic groups, compared with nondiabetic controls. A decrease (P<0.01) in glucose levels was observed in diabetic rats receiving L. brevis DPC 6108, compared with diabetic-controls. Both the composition and diversity of the intestinal microbiota were affected by diabetes. Microbial diversity in diabetic rats supplemented with low GABA was not reduced (P>0.05), compared with non-diabetic controls while all other diabetic groups displayed reduced diversity (P<0.05). L. brevis DPC 6108 atten uated hyperglycaemia induced by diabetes but additional studies are needed to understand the mechanisms involved in this reduction.

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Section: Discussionmentioning

confidence: 95%

Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

Marques

Patterson

Wall

et al. 2016

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“…Ultimately, 33 articles were included in the final analysis, consisting of five human and 28 animal reports . Information on human and animal studies in relation to methodological quality, characteristics of participants, interventions and outcome measures are summarized in Tables and .…”

Section: Resultsmentioning

confidence: 99%

“…Twelve animal reports of the selected articles assessed plasma and serum glucose levels without obtaining fasting or postprandial glucose measurements. Six of them reported significant reduction in plasma glucose levels after probiotic interventions , which conducted over 2 , four , 8 and 12 weeks of interventions.…”

Section: Resultsmentioning

confidence: 99%

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Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Razmpoosh

Javadi

Ejtahed

et al. 2015

Diabetes Metabolism Res

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Probiotics have been suggested to play an important role in the management of diabetes. We conducted a systematic review on the role of probiotics in modulating parameters related to diabetes in animal and human experiments. We searched Pubmed, Scopus and Cochrane central until June 2014, concerning the effects of probiotics on hyperglycemia, hyperinsulinemia and their anti-diabetic efficacies by modulating the activities of proinflammatory and antioxidant factors. Our initial search retrieved 1120 reports. After screening titles and abstracts, 72 full-text articles were reviewed for eligibility. Ultimately, 33 articles met our inclusion criteria consisting of five human and twenty eight animal reports. Lactobacillus strains were, in particular, used in all studies with or without other strains. We found that probiotics have beneficial effects on glycemic controls, as all human studies showed significant reductions in at least one of the primary outcome endpoints which were the levels of fasting plasma glucose, postprandial blood glucose, glycated haemoglobin, insulin, insulin resistance and onset of diabetes; similarly, all the animal reports, except for two, documented significant changes in these parameters. Regarding secondary outcome measures, that is, lipid profiles, pro-inflammatory and anti-oxidant factors, only one human and one animal study failed to show any significant changes in any of these parameters. This systematic review generally demonstrated beneficial effects of the probiotic administration, especially Lactobacillus sub-strains, on the management of diabetes-related blood parameters, although, more evidence, especially from human trials, is needed to confirm these effects and also to conduct a meta-analysis. Copyright © 2015 John Wiley & Sons, Ltd.

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“…31 Lactobacillus casei also has the potential to decrease blood glucose levels through improvement of disordered post-immune responses via inhibition of production of IL2 and interferon gamma (INF-γ) and reduction of the increases in CD3+ and CD4+ T cell counts. 38 Kingma et al 29 showed that Lactobacillus johnsonii (Ljo) N6.2 stimulates the innate immune response through activation of the membrane-bound receptors expressed in intestinal epithelial cells.…”

Section: Also Administration Of Lactobacillus Kefiranofaciens M Andmentioning

confidence: 99%

Potential mechanisms linking probiotics to diabetes: a narrative review of the literature

et al. 2017

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CONTEXT AND OBJECTIVE: Some studies have suggested a wide range of possible mechanisms through which probiotics may play a role in diabetes prevention and treatment. However, the underlying mechanisms are not fully understood. We conducted this study to review the potential mechanisms suggested for the effect of probiotics in diabetes. DESIGN AND SETTING: Narrative review conducted at the Food Security Research Center of Isfahan. METHODS: A search in the electronic databases MEDLINE (PubMed), Cochrane Library, Web of Science and Google scholar was performed up to October 2016. RESULTS:The initial search yielded 1214 reports. After removing duplicates, 704 titles and abstracts were screened. Finally, out of 83 full-text articles that were reviewed for eligibility, 30 articles were included in the final analysis. The anti-diabetic mechanisms for probiotics reported encompass intraluminal and direct effects on the intestinal mucosa and microbiota (n = 13), anti-inflammatory and immunomodulatory effects (n = 10), antioxidative effects (n = 5), effects on endoplasmic reticulum (ER) stress and expression of genes involved in glucose homeostasis and insulin resistance (n = 6), with some studies pointing to more than one mechanism. CONCLUSION: The results may throw some light on the capacity of probiotics as a novel approach towards controlling diabetes. However, further human studies are warranted to elucidate and confirm the potential role of probiotics in diabetes prevention and treatment. Also, it needs to be ascertained whether the effectiveness of probiotics in diabetes prevention and treatment is dependent on the strain of the microorganisms. Os mecanismos antidiabéticos relatados dos probióticos abrangem efeitos intraluminais e diretos na mucosa e microbiota intestinal (n = 13), efeitos anti-inflamatórios e imunomoduladores (n = 10), efeitos antioxidativos (n = 5), efeitos sobre o estresse de retículo endoplasmático (RE) e expressão de genes envolvidos na homeostase da glicose e resistência à insulina (n = 6), com alguns estudos apontando para mais de um mecanismo. CONCLUSÃO: Os resultados podem lançar alguma luz sobre os probióticos como uma nova abordagem no controle do diabetes, no entanto, mais estudos em humanos são justificados para elucidar e confirmar o papel potencial dos probióticos na prevenção e tratamento do diabetes. Além disso, deverá ser determinado se a eficácia dos probióticos na prevenção e tratamento do diabetes é dependente da cepa dos microrganismos. RESUMO IPhD. Doctoral

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Effect of Lactobacillus casei on the Production of Pro-Inflammatory Markers in Streptozotocin-Induced Diabetic Rats

Cited by 22 publications

References 48 publications

Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

Potential mechanisms linking probiotics to diabetes: a narrative review of the literature

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