Abstract:This study aimed to elucidate the impact of quercetin (Que)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA-Que) on hypoxia/reoxygenation (H/R)-induced cardiomyocyte (CM) injury and its mechanism. PLGA-Que was first prepared, and H/R CMs were intervened with either PLGA-Que
or free Que. The results showed that both PLGA-Que and free Que could enhance H/R CM viability, inhibit apoptosis, and lower the oxidative stress response. However, PLGA-Que was more protective of H/R CMs than free Que. Sub… Show more
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