Effect of Lactic Acid Bacteria-Fermented Soy Milk Extract (LEX) on Urinary 3-Indoxyl Sulfate in Japanese Healthy Adult Women: An Open-Label Pilot Study

Fukuchi, Mina; Yasutake, Takanori; Matsumoto, Miho; Mizuno, Ryohei; Fujita, Koichiro; Sasuga, Yasuhiro

doi:10.2147/nds.s281180

Cited by 5 publications

(4 citation statements)

References 36 publications

(35 reference statements)

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“…Different types of lactic acid bacteria and LAB fermented food products have evolved and provided benefits for humans and animals. These benefits include increasing the nutritional value of food, improving the ability to prevent infection, relieving symptoms of lactose intolerance, modulating the immune response, controlling cholesterol levels, and decreasing the risk of colon disease [44]. Moreover, fermentation improves the sensory characteristics of soymilk by reducing the unpleasant taste and improving the soymilk aroma and taste [12].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fermented Soymilk-Honey from Different Probiotics on Osteocalcin Level in Menopausal Women

Desfita¹,

Sari²,

Yusmarini

et al. 2021

Nutrients

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Osteoporosis has been discovered to be a risk factor for menopausal women. Although synbiotics (probiotics and prebiotics) are found in fermented soymilk-honey made using local probiotics, their effect on osteocalcin levels is still unknown. Therefore, this study’s objective was to determine the influence of fermented soymilk-honey from different probiotics on osteocalcin levels. A 90-day pre–post quasi-experimental study with a control design was conducted on 54 postmenopausal women divided into three intervention groups namely, the soymilk (SM) group, the soymilk-honey fermented with Lactobacillus casei subsp. casei R-68 (SMH Lc) group, and the soymilk-honey fermented with Lactobacillus plantarum 1 R 1.3.2 (SMH Lp) group. Participants consumed 100 mL of soymilk (SM) or fermented soymilk with honey (SMH Lc or SMH Lp) for 90 days. At the beginning and end of the study, the blood serum osteocalcin level was measured and subjects’ health status was assessed, such as cholesterol total, random blood glucose, and uric acid levels. Our results presented that in the SMH Lp group, 90 days supplementation of soy-honey milk fermented with Lactobacillus plantarum 1 R 1.3.2 significantly reduced the level of blood serum osteocalcin. Based on these results it is justified to perform more detailed studies on the effect of fermented soy-honey milk on bone health.

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Section: Discussionmentioning

confidence: 99%

Effect of Fermented Soymilk-Honey from Different Probiotics on Osteocalcin Level in Menopausal Women

Desfita¹,

Sari²,

Yusmarini

et al. 2021

Nutrients

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“…Furthermore, changes in urinary metabolites reflecting neurotransmitter levels were observed in relation to the metabolism of phenylalanine, tyrosine, or tryptophan. We recently reported that LEX ingestion decreases urinary indoxyl sulfate, a tryptophan metabolite derived from the metabolism of gut microbiota [ 12 ]. Changes in these metabolites are also presumed to be mediated by the gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to probiotic products, various other supplements such as fermented bacterial products are expected to improve GI tract symptoms. The extract of multi-strain lactic acid bacteria (LAB)-fermented soy milk (LEX) is one of them, and the effect of improving the metabolites derived from gut microbiota has been reported [ 12 ]. Another study demonstrated that LEX ingestion can prevent colon cancer and activate intestinal immunity [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of a competitive event and the efficacy of a lactic acid bacteria-fermented soymilk extract on the gut microbiota and urinary metabolites of endurance athletes: An open-label pilot study

Fukuchi¹,

Sugita

Banjo

et al. 2022

PLoS ONE

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Diet and exercise can alter the gut microbiota, but recent studies have assessed the impact of athletic competition on gut microbiota and host metabolites. We designed an open-label pilot study to investigate the effects of both official competition and a multi-strain lactic acid bacteria-fermented soymilk extract (LEX) on the gut microbiota in Japanese college endurance athletes. The analysis of fecal 16S rRNA metagenome and urinary metabolites was used to identify changes in gut microbiota composition and host metabolism. When the fecal microbiota were investigated before and after a race without using of a supplement (pre-observation period), there was an increase in the phylum Firmicutes and decrease in Bacteroidetes. However, no changes in these phyla were seen before and after a race in those who consumed LEX. Before and after LEX ingestion, changes in urinary metabolites included a significant reduction in yeast and fungal markers, neurotransmitters, and mitochondrial metabolites including the TCA cycle. There were several correlations between urinary metabolites and the composition of fecal microbiota. For example, the level of tricarballylic acid was positively correlated with the composition ratio of phylum Firmicutes (Pearson’s r = 0.66; p < 0.01). The bacterial species Parabacteroides distasonis was also found to correlate moderately with several urinary metabolites. These findings suggest two possibilities. First, endurance athletes experience significant fluctuations in gut microbiota after a single competition. Second, LEX ingestion may improve yeast and fungal overgrowth in the gastrointestinal tract and enhancing mitochondrial metabolic function.

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“…In addition, sterilized organisms and bacterial metabolites have been reported to be effective as postbiotic materials [ 8 , 9 ]. Lactobacillus fermentation extract (hereinafter referred to as LEX), which is obtained by fermenting soy milk with multiple strains of lactic acid bacteria, has been reported to have anti-colorectal adenocarcinoma effects [ 10 ], intestinal immunostimulating effects [ 11 ], effects on colon polyps [ 12 ], induce changes in the intestinal microflora, improve the intestinal environment improvement [ 13 ], etc. have been reported.…”

Section: Introductionmentioning

confidence: 99%

The Combined Effects of Sublingual Immunotherapy and Lactobacillus acidophilus-Producing Extract on Cedar Pollinosis Symptoms

Hirobumi¹,

Sasuga²

2023

Cureus

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Introduction: Sublingual immunotherapy (SLIT), in which standardized cedar pollen extract solution is administered, has been used to treat cedar pollinosis, but SLIT is problematic because it takes a long time to become effective, and some cases are ineffective even after long-term treatment. It has also been reported that lactobacillus acidophilus extract (LEX), a food-derived ingredient, alleviates various allergic symptoms. This study examined the usefulness of LEX as a treatment for cedar pollinosis in comparison with SLIT. We also examined whether the combined use of SLIT and LEX could have an early-onset of therapeutic effect on cedar pollinosis. We also examined the usefulness of LEX as a salvage therapy for patients who failed to respond to SLIT.Subjects and Methods: Fifteen patients with cedar pollinosis were divided into three groups. The three groups were: three patients in the standardized cedar pollen extract group (S group), seven patients in the lactobacillus-producing extract group (L group), and five patients in the combination group of standardized cedar pollen extract and lactobacillus-producing extract (SL group). The subjects were treated for three years, corresponding to the three scattering seasons of cedar pollen, and observed according to the evaluation items. The evaluation items were severity score based on examination findings, subjective symptom score (QOL score) based on the Japanese Standard QOL Questionnaire for Allergic Rhinitis (JRQLQ No. 1) questionnaire, nonspecific IgE level measurement by blood test, and cedar pollen-specific IgE level measurement.Results: After three years of observation, there were no significant differences in severity score and nonspecific IgE levels among the three groups, while QOL score decreased significantly between the first and third years of treatment in the L group. Cedar pollen-specific IgE levels in the S and SL groups showed an increase in the first year and a gradual decrease in the second and third years of treatment compared to the pre-treatment period. In group L, no increase was observed in the first year, and a significant decrease was observed in the second and third years during the cedar pollen dispersal period.Conclusions: The results of severity and quality of life scores indicated that it took three years of treatment for the S and SL groups to show efficacy, while the L group showed improvement in quality of life scores and cedar pollen-specific IgE levels from the first year, suggesting that LEX is useful as a treatment for cedar pollinosis. The efficacy of combination therapy with SLIT and LEX was not clear, but since the effect of LEX was observed from the early stage of treatment, it was thought that the combination therapy with LEX intake from the early stage of treatment may be effective in reducing the incidence of ineffective cases. The combination therapy of SLIT and LEX may also be useful as a salvage therapy.

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Effect of Lactic Acid Bacteria-Fermented Soy Milk Extract (LEX) on Urinary 3-Indoxyl Sulfate in Japanese Healthy Adult Women: An Open-Label Pilot Study

Cited by 5 publications

References 36 publications

Effect of Fermented Soymilk-Honey from Different Probiotics on Osteocalcin Level in Menopausal Women

Effect of Fermented Soymilk-Honey from Different Probiotics on Osteocalcin Level in Menopausal Women

The impact of a competitive event and the efficacy of a lactic acid bacteria-fermented soymilk extract on the gut microbiota and urinary metabolites of endurance athletes: An open-label pilot study

The Combined Effects of Sublingual Immunotherapy and Lactobacillus acidophilus-Producing Extract on Cedar Pollinosis Symptoms

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