Effect of lactation on the expression of audiogenic seizures: association with plasma prolactin profiles

Doretto, Maria Carolina; Oliveira-e-Silva, M.; Ferreira-Alves, Dalton L.; Pires, S.G.; García-Cairasco, Norberto; Reis, Adelina M.

doi:10.1016/s0920-1211(03)00061-5

Cited by 15 publications

(6 citation statements)

References 50 publications

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“…Furthermore, reduced c‐ fos expression in the ventral hippocampus under basal conditions suggests that PRL modulates inputs to the hippocampus (55). PRL is released into the systemic circulation in response to epileptic seizures, and long‐term PRL treatment modulates seizure activity (56). Also, the stimulatory action of NMDA on PRL release in male and female rats changes to an inhibitory action in lactating rats, in which PRL levels are increased, suggesting that the glutamate agonist cannot exert its excitatory action when PRL levels are high (57,58).…”

Section: Neuroprotective Actions Of the Hormones Of Lactation (Oestromentioning

confidence: 99%

Recent Findings on Neuroprotection Against Excitotoxicity in the Hippocampus of Female Rats

Morales

2011

J Neuroendocrinology

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Newborn mammals are totally dependent on maternal milk and care for survival. The mother’s brain undergoes different behavioural, physiological and emotional adaptations that make the mother more likely to satisfy the demands of the offspring. Recent reports from our group show that, compared to nulliparous rats, lactation diminishes cell damage induced by excitotoxicity in the dorsal hippocampus of the dam after systemic or i.c. administration of kainic acid (KA) and the resulting motor seizures. Elevated levels of prolactin (PRL), oxytocin, progesterone and glucocorticoids are characteristics of lactation, and the pronounced fluctuation of these hormones occurring in this phase may play a role protecting the hippocampus. Indeed, PRL administration to ovariectomised rats significantly diminishes the deleterious effects of KA in the dorsal hippocampus and reduces the progression of KA‐induced seizures. Thus, lactation is a natural model for neuroprotection because it effectively prevents acute and chronic cell damage of the hippocampus induced by excitotoxicity.

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Section: Neuroprotective Actions Of the Hormones Of Lactation (Oestromentioning

confidence: 99%

Recent Findings on Neuroprotection Against Excitotoxicity in the Hippocampus of Female Rats

Morales

2011

J Neuroendocrinology

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“…One such example, the Wistar audiogenic rat (WAR), comprises an audiogenic reflex epilepsy animal model obtained by inbreeding, from Wistar breeding stocks, of seizure-susceptible rats to high-intensity acoustic stimuli. As a consequence, sporadically presenting high-intensity acoustic stimuli to WARs triggers brainstem circuitry-dependent generalized tonic-clonic seizures [3][4][5][6][7][8]. When repeatedly stimulated (audiogenic kindling) [4,9,10], WARs become a two-in-one model as epileptogenic neural substrates gradually compromise, through on-demand seizures, more rostral prosencephalic structures [4,8,11].…”

Section: Introductionmentioning

confidence: 99%

Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

Castro

Medeiros

Guarnieri

et al. 2017

Epilepsy & Behavior

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Accumulating evidence from different animal models has contributed to the understanding of the bidirectional comorbidity associations between the epileptic condition and behavioral abnormalities. A strain of animals inbred to enhance seizure predisposition to high-intensity sound stimulation, the Wistar audiogenic rat (WAR), underwent several behavioral tests: forced swim test (FST), open-field test (OFT), sucrose preference test (SPT), elevated plus maze (EPM), social preference (SP), marble burying test (MBT), inhibitory avoidance (IAT), and two-way active avoidance (TWAA). The choice of tests aimed to investigate the correlation between underlying circuits believed to be participating in both WAR's innate susceptibility to sound-triggered seizures and the neurobiological substrates associated with test performance. Comparing WAR with its Wistar counterpart (i.e., resistant to audiogenic seizures) showed that WARs present behavioral despair traits (e.g., increased FST immobility) but no evidence of anhedonic behavior (e.g., increased sucrose consumption in SPT) or social impairment (e.g., no difference regarding juvenile exploration in SP). In addition, tests suggested that WARs are unable to properly evaluate degrees of aversiveness (e.g., performance on OFT, EPM, MBT, IAT, and TWAA). The particularities of the WAR model opens new venues to further untangle the neurobiology underlying the co-morbidity of behavioral disorders and epilepsy. This article is part of a Special Issue entitled "Genetic and Reflex Epilepsies, Audiogenic Seizures and Strains: From Experimental Models to the Clinic".

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“…Plasma PRL levels were measured in duplicate by radioimmunoassay (RIA), using materials provided by NIADDK (Bethesda, MD, USA). The intra- and inter-assay coefficients of variation were 6% and 8%, respectively [21]. …”

Section: Methodsmentioning

confidence: 99%

Alstonine as an Antipsychotic: Effects on Brain Amines and Metabolic Changes

Linck

Herrmann

Piato

et al. 2011

Evidence-Based Complementary and Alternative Medicine

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Managing schizophrenia has never been a trivial matter. Furthermore, while classical antipsychotics induce extrapyramidal side effects and hyperprolactinaemia, atypical antipsychotics lead to diabetes, hyperlipidaemia, and weight gain. Moreover, even with newer drugs, a sizable proportion of patients do not show significant improvement. Alstonine is an indole alkaloid identified as the major component of a plant-based remedy used in Nigeria to treat the mentally ill. Alstonine presents a clear antipsychotic profile in rodents, apparently with differential effects in distinct dopaminergic pathways. The aim of this study was to complement the antipsychotic profile of alstonine, verifying its effects on brain amines in mouse frontal cortex and striatum. Additionally, we examined if alstonine induces some hormonal and metabolic changes common to antipsychotics. HPLC data reveal that alstonine increases serotonergic transmission and increases intraneuronal dopamine catabolism. In relation to possible side effects, preliminary data suggest that alstonine does not affect prolactin levels, does not induce gains in body weight, but prevents the expected fasting-induced decrease in glucose levels. Overall, this study reinforces the proposal that alstonine is a potential innovative antipsychotic, and that a comprehensive understanding of its neurochemical basis may open new avenues to developing newer antipsychotic medications.

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Effect of lactation on the expression of audiogenic seizures: association with plasma prolactin profiles

Cited by 15 publications

References 50 publications

Recent Findings on Neuroprotection Against Excitotoxicity in the Hippocampus of Female Rats

Recent Findings on Neuroprotection Against Excitotoxicity in the Hippocampus of Female Rats

Wistar audiogenic rats display abnormal behavioral traits associated with artificial selection for seizure susceptibility

Alstonine as an Antipsychotic: Effects on Brain Amines and Metabolic Changes

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