Effect of l-DOPA and N-Methyl-N-benzyl-2-propynylamine.HCl on DOPA, dopamine, norepinephrine, epinephrine and serotonin levels in mouse brain

Wiegand, Ronald G.; Perry, J.E.

doi:10.1016/0006-2952(61)90084-3

Cited by 80 publications

(13 citation statements)

References 7 publications

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“…Goldberg (1964), Sj6qvist (1965) and other workers who have reported interactions between monoamine oxidase inhibitors and sympathomimetic amines base their explanations on the following sequence of events: when intraneuronal monoamine oxidase is inhibited the noradrenaline stores increase and hence larger amounts of noradrenaline will be liberated by noradrenaline-releasing drugs. Monoamine oxidase inhibitors have been reported to elevate the content of catecholamines in the brain of rat, rabbit, mouse, monkey and man (Bums & Shore, 1961;Crout et al, 1961;Wiegand & Perry, 1961;Maling, Highman & Spector, 1962;Ganrot, Rosengren & Gottfries, 1962;Spector, 1963) and in the heart of rat, guinea-pig and dog (Pletscher & Pellmont, 1958;Crout et a)., 1961;Kopin, 1964), but no significant change in the catecholamine level has been found in the brain of cat and dog (Vogt, 1954;Spector, Shore & Brodie, 1960;Burns & Shore, 1961;Maling et al, 1962) or in rabbit and mouse heart (Spector et al, 1960;Goldberg & Shideman, 1962). The atria from nialamide treated kittens exhibited diminished inotropic activity in response to direct and indirectly acting sympathomimetics.…”

Section: Pressor Responses In Pithed Ratsmentioning

confidence: 99%

The Mechanism of the Augmentation of Responses to Indirectly Acting Sympathomimetic Amines by Monoamine Oxidase Inhibitors

Rand

Trinker

1968

British Journal of Pharmacology and Chemotherapy

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Section: Pressor Responses In Pithed Ratsmentioning

confidence: 99%

The Mechanism of the Augmentation of Responses to Indirectly Acting Sympathomimetic Amines by Monoamine Oxidase Inhibitors

Rand

Trinker

1968

British Journal of Pharmacology and Chemotherapy

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“…Recent evidence seems to indicate that dopamine is a neurohormone with transmitter functions in the central nervous system (22,26,27,(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65). In view of these findings and the fact that both dopamine and noradrenaline are decreased in the caudate, putamen, and substantia nigra in parkinsonism (24) The method for isolating and quantifying endogenous noradrenaline and the metabolic products of noradrenaline, as well as the metabolic products of dopamine, has been previously described (65,66).…”

mentioning

confidence: 99%

Dopamine (3-Hydroxytyramine) metabolism in parkinsonism

Goodall¹,

Alton²

1969

J. Clin. Invest.

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A B S T R A C T Three patients with idiopathic parkinsonism and six normal subjects were infused over a 4 hr period with 104.6 sc of dopamine-2'C (3,4-dihydroxyphenylethylamine, 3-hydroxytyramine) ,' the immediate precursor in the synthesis of the sympathetic neurohormone, noradrenaline (norepinephrine). Urine was collected during the infusion period, 0-2 hr, 2-4 hr, 4-8 hr, 8-24 hr, and thereafter for 4 additional days. Using a technique herein described, the various metabolic and biosynthetic products of dopamine, including noradrenaline and its metabolic products, were separated, identified, and their radioactivity measured.The metabolic pattern of dopamine in the normal subject was compared to that of the three parkinsonism patients. The results indicate that in idiopathic parkinsonism there is a decrease in the recovery of free radioactive noradrenaline in the urine following an infusion of dopamine-2-"'C and a slight shift toward dopamine metabolism. The latter is reflected by an increase in the following metabolites of dopamine: 3,4-dihydroxyphenylacetic acid and the conjugates of 3-methoxy-4-hydroxyphenylacetic acid, 3,4-dihydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylethanol and dopamine.

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“…NE tent of the final supernatant and the final centrifugate, and E were determined at pH 6.5 and E at pH 3.5. performed in duplicate, were determined by the fluori-HVA was measured by the method of SANKOFF and metric method of SHORE and OLIN [46], as modified SOURKES [44] or by the method of SATO [45]. Dopa-by WEIGAND and PERRY [57]. Data were calculated mine was determined by a modification of the method by relating the amount of NE or E released into the of DRUJAN et al…”

Section: Methodsmentioning

confidence: 99%

Catecholamine Metabolism of a Ganglioneuroma: Correlation with Electronmicrographs

et al. 1969

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ExtractStudies of the catecholamine metabolism in a patient having a functional ganglioneuroma are reported. Biochemical determinations of catecholamines and metabolites were correlated with histochemical and electron microscopic examination of the tumor. Increased urinary excretion of 3-methoxy-4-hydroxy mandelic acid, homovanillic acid, and dopamine was found prior to excision of the tumor. There was no significant increase in excretion of normetanephrine-metanephrine or of norepinephrine-epinephrine. Concentration of norepinephrine and epinephrine in the tumor tissue was 0.095 mglg. This concentration is greater than that found in neuroblastomas, but less than that found in pheochromocytomas. Normetanephrine-metanephrine was detected in the tumor tissue, indicating degradation of norepinephrine by catechol-0-methyl transferase. Computed turnover of norepinephrine in the tumor tissue was 6.85 hours.Catecholamines were present within heavy mitochondria1 fractions prepared from tumor tissue; the spontaneous release of norepinephrine into the suspending medium was determined during incubation under standard conditions. The data indicate that rapid turnover of norepinephrine was not related to accelerated spontaneous release from catecholamine granules. Electron microscopic examination revealed ganglion cells and a complex neuropil. Dense core vesicles were present in many of the neural processes and in ganglion cells. Synaptic junctions between neural processes and between neural processes and ganglion cells were seen. Nerve bundles containing neural processes were present. There was wide variation in the cross sectional diameter of the processes.The number of Type I dense core vesicles of this ganglioneuroma were decreased in comparison with those found in pheochromocytomas and increased in relation to neuroblastomas.The synapse-like areas of membrane specialization observed in this tumor may have been part of the mechanism by which differentiation of the ganglion cells was directed. The high rate of turnover of catecholamines does not seem to be dependent upon an increased rate of spontaneous release of catecholamines from isolated secretory vesicles.

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Effect of l-DOPA and N-Methyl-N-benzyl-2-propynylamine.HCl on DOPA, dopamine, norepinephrine, epinephrine and serotonin levels in mouse brain

Cited by 80 publications

References 7 publications

The Mechanism of the Augmentation of Responses to Indirectly Acting Sympathomimetic Amines by Monoamine Oxidase Inhibitors

The Mechanism of the Augmentation of Responses to Indirectly Acting Sympathomimetic Amines by Monoamine Oxidase Inhibitors

Dopamine (3-Hydroxytyramine) metabolism in parkinsonism

Catecholamine Metabolism of a Ganglioneuroma: Correlation with Electronmicrographs

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