Effect of L-arginine on amniotic fluid index in oligohydramnios

Efficacy of oral L-arginine on amniotic fluid index in pregnant women with oligohydramnios attending antenatal clinic in a tertiary care hospital in Telangana, India

“…3,4 In this study, the mean gestational age (SD) at the time of diagnosis was 34.61 (1.53) weeks whereas mean GA was 31.1±2 weeks and 32.3 weeks in a study done in Wardha, Maharashtra and Powai, Maharashtra, India respectively. 1,15 Mean AFI (SD) before and after treatment with L-arginine were noted to be 6.8 (1.3) cm and 9.4 (2.82) cm in this study, which is comparable with the values in the studies done at Powai, Maharashtra and Udaipur, Rajasthan, India. 1,4 A mean (SD) increase of AFI by 2.6 (1.57) cm was observed in this study which is similar to that reported in the study done in Powai, Maharashtra and slightly more than that in Wardha, Maharashtra, India.…”

“…1 Mean age (SD) of the women enrolled in this study was 23.3 (3.49) years which was similar to the study done in Karimnagar, Telangana and Wardha, Maharashtra, India. 3,15 Majority of the cases were primigravidae, a similar finding to that of a study conducted in Karimnagar, Telangana and Udaipur, Rajasthan, India. 3,4 In this study, the mean gestational age (SD) at the time of diagnosis was 34.61 (1.53) weeks whereas mean GA was 31.1±2 weeks and 32.3 weeks in a study done in Wardha, Maharashtra and Powai, Maharashtra, India respectively.…”

“…1,4 A mean (SD) increase of AFI by 2.6 (1.57) cm was observed in this study which is similar to that reported in the study done in Powai, Maharashtra and slightly more than that in Wardha, Maharashtra, India. 1,15 However, the increase was statistically significant.…”

http://www.iosrjournals.org/iosr-jdms/papers/Vol16-issue4/Version-4/C1604041315.pdf

“…Sreedharan et al studied the effect of l-arginine in 100women diagnosed to have oligoamnios between 28 and 36 weeks of gestation. [9] The expectant mothers were prescribed sachets of l-arginine containing 3 g of the active ingredient for periods varying between 1 and 4 weeks. There was significant improvement in AFI (by 2.03 ± 0.39 cm),and they opined that l-arginine can be used as a cheaper alternative to ultrasound-guided amnioinfusion in pregnancy complicated by low liquor remote from term.…”

“…Shripad Hebbar et al studied the effect of Maternal hydration and L-arginine supplementation in improving liquor volume in patients with decreased liquor and prolongs pregnancy [9] Treatment with l-arginine and fructodex resulted in significant improvement in liquor mean increase in AFI WAS found to be 2.4 and mean increase in gestational age was 2.9 weeks in their study . In our study the mean duration of treatment was 2.3 ± 1.1 weeks which was similar to study by Anita Soni et al in which duration of therapy in study was 2.4 ± 1.1 weeks (10) Therefore, studies recommend the supplementation of L-arginine and antioxidants in pregnancy to maintain the levels of NO so as to facilitate the requiredvasodilatation and have a beneficial role in the fetal growth.…”