Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes

Tode, Takehiko; Kikuchi, Yasufumi; Hirata, Junko; Kita, Tamotsu; Nakata, Hiroko; Nagata, Ichiro

doi:10.1016/s0020-7292(99)00168-x

Cited by 89 publications

(48 citation statements)

References 14 publications

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“…Sparsely, ginseng has been reported to possess positive effects against herpes simplex type-II infections and diabetes mellitus, common cold symptom complex, ethanol-induced gastric lesion, and aspirin-induced gastric ulcers (131). Another study showed that ginseng helped postmenopausal women to alleviate climacteric syndromes, particularly fatigue, insomnia, and depression (132).…”

Section: Clinical Aspects Of Ginsengmentioning

confidence: 99%

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Gille²,

et al. 2006

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Abstract. Ginseng, the root of Panax species, is a well-known herbal medicine. It has been used as a traditional medicine in China, Korea, and Japan for thousands of years and is now a popular and worldwide used natural medicine. The active ingredients of ginseng are ginsenosides which are also called ginseng saponins. Recently, there is increasing evidence in the literature on the pharmacological and physiological actions of ginseng. However, ginseng has been used primarily as a tonic to invigorate week bodies and help the restoration of homeostasis. Current in vivo and in vitro studies have shown its beneficial effects in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency, and hepatotoxicity. Moreover, recent research has suggested that some of ginseng's active ingredients also exert beneficial effects on aging, central nervous system (CNS) disorders, and neurodegenerative diseases. In general, antioxidant, anti-inflammatory, anti-apoptotic, and immune-stimulatory activities are mostly underlying the possible ginseng-mediated protective mechanisms. Next to animal studies, data from neural cell cultures contribute to the understanding of these mechanisms that involve decreasing nitric oxide (NO), scavenging of free radicals, and counteracting excitotoxicity. In this review, we focus on recently reported medicinal effects of ginseng and summarize the current knowledge of its effects on CNS disorders and neurodegenerative diseases.

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Section: Clinical Aspects Of Ginsengmentioning

confidence: 99%

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Gille²,

et al. 2006

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“…4). Several models have been described that induce apoptosis using a number of different stimuli, such as, depriva-tion of growth factors (Wang et al, 2006), surface receptor-ligand binding (Tode et al, 1999), cytokines (Larrick and Wright, 1990), DNA damage (Kaufmann, 1989), and abortive cell cycle progression (Furukawa et al, 1996). The ability of a cell to undergo apoptosis in response to a death signal is related to its proliferative status, cell cycle position, and to the controlled expression of genes that affect the cell-death program.…”

Section: The Pkc Activator Tpa Prevented Cells From Costunolide-indmentioning

confidence: 99%

“…Thus, cell populations are controlled, autoreactive immune cells are eliminated, and virus-infected and neoplastic cells are killed by apoptosis (Jacobson et al, 1997). Furthermore, various exogenous and endogenous stimuli, such as, receptor-ligand interactions (Tode et al, 1999), radiation (Hendry et al, 1995), cytokine (Larrick and Wright, 1990), and anti-cancer drugs (Hickman, 1992) induce apoptosis, which characteristically results in chromatin condensation, the formation of apoptotic bodies, and DNA fragmentation. Furthermore, it has been shown that some cancer chemotherapeutics and chemopreventives exert their effects by triggering either apoptotic cell death or cell cycle transition, and thus, the induction of tumor cell apoptosis is used to predict tumor treatment response (Kim et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Costunolide Induces Apoptosis via Modulation of Cyclin-Dependent Kinase in HL-60 Human Leukemia Cells

Kim¹,

Choi²,

Park³

et al. 2010

Biomolecules and Therapeutics

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-Costunolide is an active compound isolated from the stem bark of Magnolia sieboldii, and is considered a potential therapeutic for the treatment of various cancers. In this study, we investigated the underlying mechanism whereby costunolide induces the apoptosis of human leukemia cells. Using apoptosis analysis and quantitative reverse transcription-polymerase chain reaction (RT-PCR) results obtained during this study show that costunolide is a potent inducer of apoptosis and that it is triggered due to the premature activation of Cdc2. G 1 -synchronized cells, which cannot undergo mitosis, were found to be more sensitive to costunolide, and Cdc2 mRNA levels were increased by costunolide treatment. Furthermore, the Cdk inhibitors, olomucine and butyrolactone I, were found to suppress costunolide-induced apoptosis. In addition, the PKC activator TPA rescued cells from cell death by costunolide, and this was prevented by the PKC inhibitor staurosporin. The present study suggests that costunolide induces the apoptosis of HL-60 leukemic cells by modulating cyclin-dependent kinase Cdc2.

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“…There is also very little data available on the efficacy and safety of many of these compounds, either used alone or in combination with other herbs. Table 2 [58][59][60][61][62][63][64][65][66][67][68][69] summarizes the available data on the clinical trials that have been conducted on these botanicals for menopausal women in specific. Trials conducted on non-menopausal populations are discussed in the text.…”

Section: Other Commonly Used Botanicalsmentioning

confidence: 99%

“…Both showed no estrogenic effects, no improvement in vasomotor symptoms, but improvement in somatic complaints (fatigue, insomnia, and depression) and a favorable effect on depression and well-being health subscales compared with placebo. [66,67] There is no consensus, but ginseng does not appear to have estrogenic activity by in vitro assay or in vivo biological assay although it is contraindicated in presence of breast cancer. [80] …”

Section: Ginseng (Panax Ginseng)mentioning

confidence: 99%

Contemporary alternatives to plant estrogens for menopause

Geller¹,

Studee²

2006

Maturitas

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Objectives-Every year, millions of women begin the peri-menopause and may experience a number of symptoms related to this transition. Many women are reluctant to use exogenous hormone therapy for treatment of menopausal symptoms and are turning to botanical and dietary supplements (BDS) for relief. This paper reviews the literature on alternatives to plant estrogens for relief of menopausal symptoms.Methods-The MEDLINE database was searched for clinical trials of non-estrogenic plant extracts for menopausal symptoms. To be included, studies had to include peri-or postmenopausal women as subjects. All clinical trials (randomized-controlled trials, open trials, and comparison group studies) were included for this review. Results-BlackCohosh appears to be one of the most effective botanicals for relief of vasomotor symptoms, while St. John's wort can improve mood disorders related to the menopausal transition. Many other botanicals have limited evidence to demonstrate safety and efficacy for relief of symptoms related to menopause.Conclusions-A growing body of evidence suggests that some botanicals and dietary supplements could result in improved clinical outcomes. Health care providers should discuss these issues with their patients so they can assist them in managing these alternative therapies through an evidencebased approach.

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Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes

Abstract: Improvement of CMI and STAI scores in postmenopausal women suffering climacteric syndromes, particularly fatigue, insomnia and depression, by RG seemed to be brought about in part by effects of RG on stress-related hormones as shown by a decrease in C/D ratio.

Cited by 89 publications

References 14 publications

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Costunolide Induces Apoptosis via Modulation of Cyclin-Dependent Kinase in HL-60 Human Leukemia Cells

Contemporary alternatives to plant estrogens for menopause

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