Effect of Korean Red Ginseng Supplementation on Ocular Blood Flow in Patients with Glaucoma

Kim, Na Rae; Kim, Ji Hyun; Kim, Chan Yun

doi:10.5142/jgr.2010.34.3.237

Cited by 16 publications

(22 citation statements)

References 42 publications

(51 reference statements)

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“…The included RCTs used ginseng powder either in raw (4 studies) [35], [38], [53], [55] or in capsules (22 studies) [26]–[29], [31], [32], [34], [36], [37], [39]–[41], [43]–[48], [50]–[52], [54] and extract preparation (2 studies) [33], [42], while two studies [30], [49] did not report the preparation type of ginseng. They addressed a wide range of conditions: generally healthy (i.e., studies in healthy individuals) [26]–[34], erectile dysfunction [35]–[40], gastric cancer [41], [43], colon cancer [42], gastrointestinal carcinoma [44], chronic gastritis [45], diabetes mellitus [46], [47], androgenic alopecia [48], coronary artery [49], dry mouth [50], glaucoma [51], obesity [52], metabolic syndrome [53], dyspepsia and indigestion [54] and Alzheimer’s disease [55].…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies [28], [32], [34], [44], [47], [50]–[53] used methods of random sequence generation. Of those, four RCTs [28], [47], [51], [53] used a computerised randomisation method. However, the risk of bias in the sequence generation was high in five RCTs [32], [34], [44], [50], [52].…”

Section: Resultsmentioning

confidence: 99%

“…Forteen RCTs [27], [29], [31], [33], [36], [37], [40], [43], [45], [46], [48], [52], [53], [55] had a high risk of drop-out or withdrawal bias. Only six RCTs [26], [32], [35], [41], [47], [51] used intention-to-treat analysis (ITT). The risk of bias in selective outcome reporting was low in seven RCTs [26], [32], [45], [50], [51], [53], [54], high in two studies [32], [52] and unclear in the remaining studies.…”

Section: Resultsmentioning

confidence: 99%

“…Only six RCTs [26], [32], [35], [41], [47], [51] used intention-to-treat analysis (ITT). The risk of bias in selective outcome reporting was low in seven RCTs [26], [32], [45], [50], [51], [53], [54], high in two studies [32], [52] and unclear in the remaining studies. There were no difference between low risk of bias and high risk of bias when comparing the effectiveness of ginseng.…”

Section: Resultsmentioning

confidence: 99%

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Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature

et al. 2013

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ObjectiveThis systematic review was performed to summarise randomised clinical trials (RCTs) assessing the efficacy and safety of ginseng in the Korean literature.MethodThe study involved systematic searches conducted in eight Korean Medical databases. The methodological quality of all of the included studies was assessed using the Cochrane Risk of Bias tool. We included all RCTs on any type of ginseng compared to placebo, active treatment or no treatment in healthy individuals or patients regardless of conditions.ResultsIn total, 1415 potentially relevant studies were identified, and 30 randomised clinical trials were included. Nine RCTs assessed the effects of ginseng on exercise capacity, cognitive performance, somatic symptoms, quality of life, and sleeping in healthy persons. Six RCTs tested ginseng compared with placebo for erectile dysfunction, while another four studies evaluated the effects of ginseng against no treatment for gastric and colon cancer. Two RCTs compared the effect of red ginseng on diabetes mellitus with no treatment or placebo, and the other nine RCTs assessed the effects of ginseng compared with placebo or no treatment on various conditions. The methodological caveats of the included trials make their contribution to the current clinical evidence of ginseng somewhat limited. However, the 20 newly added trials (66.7% of the 30 trials) may provide useful information for future trials. Ginseng appears to be generally safe, and no serious adverse effects have been reported.ConclusionsThe clinical effects of ginseng have been tested in a wide range of conditions in Korea. Although the quality of RCTs published in the Korean literature was generally poor, this review is useful for researchers to access studies that were originally published in languages that they would otherwise be unable to read and due to the paucity of evidence on this subject.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature

et al. 2013

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“…In clinical trials on patients with glaucoma, oral administration of Korean Red Ginseng (KRG) showed considerable increases in retinal blood flow in the temporal peripapillary areas. Since swelling of blood vessels and reduction of blood flow are the important risk factors for the optic nerve damage in glaucoma; increasing the retinal blood flow may be helpful in its prevention [63]. Since ginsenosides are known to inhibit TNF- α , ginseng may also be important in the prevention of AMD, since inflammation is one of the major risk factors for the disease [64].…”

Section: Botanical Compounds and Their Effects On Eye Diseasesmentioning

confidence: 99%

Botanical Compounds: Effects on Major Eye Diseases

Huynh

Mann

Mandal

2013

Evidence-Based Complementary and Alternative Medicine

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Botanical compounds have been widely used throughout history as cures for various diseases and ailments. Many of these compounds exhibit strong antioxidative, anti-inflammatory, and antiapoptotic properties. These are also common damaging mechanisms apparent in several ocular diseases, including age-related macular degeneration (AMD), glaucoma, diabetic retinopathy, cataract, and retinitis pigmentosa. In recent years, there have been many epidemiological and clinical studies that have demonstrated the beneficial effects of plant-derived compounds, such as curcumin, lutein and zeaxanthin, danshen, ginseng, and many more, on these ocular pathologies. Studies in cell cultures and animal models showed promising results for their uses in eye diseases. While there are many apparent significant correlations, further investigation is needed to uncover the mechanistic pathways of these botanical compounds in order to reach widespread pharmaceutical use and provide noninvasive alternatives for prevention and treatments of the major eye diseases.

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Panax ginseng in Randomised Controlled Trials: A Systematic Review

Shergis

Zhang

Zhou

et al. 2012

Phytotherapy Research

123

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Panax ginseng C.A. Meyer is a common herb with many purported health benefits. However, there is no conclusive evidence supporting its use in the treatment of any particular disease. We conducted a systematic review to evaluate randomised controlled trials. Four English databases were searched with no publication date restriction. Included studies evaluated P. ginseng in patients with any type of disease or in healthy individuals. We assessed the quality of studies using the Cochrane risk of bias tool. Of the 475 potentially relevant studies, 65 met the inclusion criteria. These studies examined P. ginseng's effects on psychomotor performance (17 studies), physical performance (ten), circulatory system (eight), glucose metabolism (six), the respiratory system (five), erectile dysfunction (four), immunomodulation (four), quality of life/mood (four), antioxidant function (two), cancer (two), menopausal symptoms (two) and dry mouth (one). The risk of bias was unclear in most studies. Authors evaluated adverse events in 40 studies, with 135 minor events and no serious adverse events reported. P. ginseng shows promising results for improving glucose metabolism and moderating the immune response. This may have implications for several diseases including type 2 diabetes and chronic respiratory conditions. Further studies are needed to explore P. ginseng's potential as an effective treatment for these and other health conditions.

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Effect of Korean Red Ginseng Supplementation on Ocular Blood Flow in Patients with Glaucoma

Cited by 16 publications

References 42 publications

Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature

Ginseng for Health Care: A Systematic Review of Randomized Controlled Trials in Korean Literature

Botanical Compounds: Effects on Major Eye Diseases

Panax ginseng in Randomised Controlled Trials: A Systematic Review

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