Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study

Bae, Hyoung Won; Kim, Ji Hyun; Kim, Sangah; Kim, Minkyo; Lee, Naeun; Hong, Samin; Seong, Gong Je; Kim, Chan Yun

doi:10.1016/j.jgr.2014.07.002

Cited by 17 publications

(15 citation statements)

References 57 publications

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“…Recently, in a randomized, double-blind, placebo-controlled study, Bae et al 35 reported that Korean red ginseng supplementation given for 8 weeks significantly improved tear film stability and total ocular surface disease index score in patients with glaucoma and established topical hypotensive therapy, confirming the previous findings of an earlier study performed by the authors. 36 Ginseng (the root of Panax ginseng ) contains a variety of active components, including ginsenoides, polysaccharides, peptides, polyacetylenic alcohols, and fatty acids.…”

Section: Discussionsupporting

confidence: 73%

Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study

Tellez-Vazquez

2016

OPTH

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PurposeThe purpose of this study is to assess the effectiveness and tolerability of a dietary supplement with a combination of omega-3 fatty acids and antioxidants on dry eye symptoms caused by chronic instillation of antihypertensive eye drops in patients with glaucoma.Patients and methodsA total of 1,255 patients with glaucoma and dry eye symptoms related to antiglaucoma topical medication participated in an open-label, uncontrolled, prospective, and multicenter study and were instructed to take three capsules a day of the nutraceutical formulation (Brudypio® 1.5 g) for 12 weeks. Dry eye symptoms (graded as 0–3 [none to severe, respectively]), conjunctival hyperemia, tear breakup time, Schirmer I test, Oxford grading scheme, and intraocular pressure were assessed.ResultsAfter 12 weeks of administration of the dietary supplement, all dry eye symptoms improved significantly (P<0.001) (mean 1.3 vs 0.6 for scratching, 1.4 vs 0.7 for stinging sensation, 1.6 vs 0.7 for grittiness, 1.0 vs 0.4 for tired eyes, 1.1 vs 0.5 for grating sensation, and 0.8 vs 0.3 for blurry vision). The Schirmer test scores and the tear breakup time also increased significantly. There was an increase in the percentage of patients grading 0–I in the Oxford scale and a decrease in those grading IV–V. Compliance was recorded in 62.5% of patients. In compliant patients, the mean differences at 12 weeks vs baseline of dry eye symptoms were statistically significant as compared to noncompliant patients.ConclusionDietary supplementation with Brudypio® may be a clinically valuable additional option for the treatment of dry eye syndrome in patients with glaucoma using antiglaucoma eye drops. These results require confirmation with an appropriately designed randomized controlled study.

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Section: Discussionsupporting

confidence: 73%

Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study

Tellez-Vazquez

2016

OPTH

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“…Scleral lens device to maintain a reservoir of tears to wet and lubricate the ocular surface 267,268 Acupuncture Possible effects on dry eye signs and symptoms, as compared to sham-treated controls or artificial tears [269][270][271] ShengJinRun ZaoYangXue granules Improve tear flow and reduce dry eye symptoms 272 Korean red ginseng Improve tear film stability and reduce dry eye symptoms 273 Suppressing transient receptor potential vanilloid 1 (TRPV1) receptor Trefoil factor family peptide 3 (TFF3) Stabilize mucous layer 279,280 Nerve growth factor & mimetics Increase goblet cell number and MUC5AC production; increase corneal sensitivity; promote corneal epithelial wound healing 281,282 Tamarind seed polysaccharide Mimic the mucoadhesive mucin properties [283][284][285][286] Nanoparticles Deliver plasmids coding for MUC5AC protein to the ocular surface 287,288 M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 294,295 Salivary gland transplantation Replace dysfunctional lacrimal gland [296][297][298] Generation of two-and threedimensional lacrimal gland constructs for lacrimal gland regeneration Serve as bioengineered lacrimal gland replacement 299 Oculeve electrode device Stimulate the lacrimal nerve to induce aqueous tear production [300][301][302] Oral anethole triothine Increase Schirmer wetting score 303 Oral uridine Stimulate tear and mucin secretion after metabolism into P2Y2 agonist 304 Oral hydroxychloroquine Increase Schirmer wetting score in in Sjögren's syndrome patients with anti-fodrin antibodies 305 Oral pilocarpine and cevimeline Reduce subjective eye symptoms in Sjögren's syndrome patients, with no effect on tear volume [306][307][308] Lacritin...…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Report of the Inaugural Meeting of the TFOS i2 = initiating innovation Series: Targeting the Unmet Need for Dry Eye Treatment

et al. 2016

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On March 21, 2015, a meeting was held in London, United Kingdom, to address the progress in targeting the unmet need for dry eye disease (DED) treatment. The meeting, which launched the i(2) = initiating innovation series, was sponsored by the Tear Film & Ocular Surface Society (TFOS; www.TearFilm.org) and supported by Dompé. The TFOS i(2) meeting was designed to review advances in the understanding of DED since publication of the 2007 TFOS International Dry Eye WorkShop (DEWS) report, and to help launch the highly anticipated sequel, DEWS II. The meeting was structured to discuss the scope of the DED problem, to review the clinical challenges of DED, and to consider the treatment challenges of DED. This article provides a synopsis of the presentations of this TFOS i(2) meeting.

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“…Many people who suffer from glaucoma and use associated medications complain of dry eye and have a higher prevalence of ocular surface disease than the general population [156,157]. The preservative within the drops (benzalkonuim chloride (BAK)) has been suggested as the cause of the reported associated inflammation, blepharitis and DED [158]. Red ginseng is a traditional folk remedy used in East Asia to treat a number of disorders including endocrine and immune disorders [158].…”

Section: Other Functional Foodsmentioning

confidence: 99%

“…The preservative within the drops (benzalkonuim chloride (BAK)) has been suggested as the cause of the reported associated inflammation, blepharitis and DED [158]. Red ginseng is a traditional folk remedy used in East Asia to treat a number of disorders including endocrine and immune disorders [158]. The chronic inflammatory association and goblet cells loss in DED are commonly treated with anti-inflammatory drugs.…”

Section: Other Functional Foodsmentioning

confidence: 99%

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The Case for a More Holistic Approach to Dry Eye Disease: Is It Time to Move beyond Antibiotics?

Tavakoli

Flanagan

2019

Antibiotics

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Dry eye disease (DED) is one of the most frequent presentations to optometrists with over 16 million US adults (6.8% of adult population) diagnosed as having this disorder. The majority of associated marketed products offer relief from symptomatology but do not address aetiology. DED harbours many distinguishing features of a chronic inflammatory disorder. The recent explosion in human microbiome research has sparked interest in the ocular microbiome and its role in the preservation and extension of ocular surface health and in the contribution of the gut microbiome to chronic systemic inflammation and associated “Western life-style” diseases. With a significant lack of success for many patients using currently available DED treatments, in this era of the microbiome, we are interested in exploring potential novel therapies that aim to reconstitute healthy bacterial communities both locally and distally (in the gut) as a treatment for DED. Although this direction of investigation is in its infancy, burgeoning interest makes such a review timely. This paper considers a number of studies into the use functional foods and associated products to ameliorate dry eye.

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Effect of Korean Red Ginseng supplementation on dry eye syndrome in glaucoma patients – A randomized, double-blind, placebo-controlled study

Cited by 17 publications

References 57 publications

Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study

Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study

Report of the Inaugural Meeting of the TFOS i2 = initiating innovation Series: Targeting the Unmet Need for Dry Eye Treatment

The Case for a More Holistic Approach to Dry Eye Disease: Is It Time to Move beyond Antibiotics?

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