Effect of Kidney Transplantation on Smoking Habits of Kidney Donors

Keleş, Mustafa; Avşar, Ümit; Avsar, Z.M.; Emre, Habib; Çankaya, Erdem; Cansever, Zeliha; Kaya, Avni; Topdağı, Ömer; Uyanik, Abdullah; Aydınlı, Bülent

doi:10.1016/j.transproceed.2015.04.055

Cited by 5 publications

(7 citation statements)

References 14 publications

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“…For live kidney donors, transplantation provides an opportunity to quit cigarette smoking. Keles et al reported significant drop in cigarette smoking from 47% to 29% after kidney donation [ 30 ]. Therefore, kidney donors with history of cigarette smoking should be referred to smoking cessation clinics.…”

Section: Cigarette Smoking and Kidney Donorsmentioning

confidence: 99%

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Cigarette Smoking and Its Hazards in Kidney Transplantation

Khalil¹,

Tan

Khamis³

et al. 2017

Advances in Medicine

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Cigarette smoking affects many organs. It causes vasoconstriction through activation of sympathetic nervous system which leads to elevation of blood pressure and reduction in glomerular filtration rate and filtration pressure. It also causes thickening of renal arterioles. Cigarette smoking increases the risk of microalbuminuria and accelerates progression of microalbuminuria to macroalbuminuria. Furthermore, it causes rapid loss of glomerular filtration rate in chronic kidney disease patients. After kidney donation, these factors may be injurious to the solitary kidney. Kidney donors with history of cigarette smoking are prone to develop perioperative complications, pneumonia, and wound infection. Postkidney transplantation various stressors including warm and cold ischemia time, delayed graft function, and exposure to calcineurin inhibitors may result in poor graft function. Continuation of cigarette smoking in kidney transplant recipients will add further risk. In this review, we will specifically discuss the effects of cigarette smoking on normal kidneys, live kidney donors, and kidney transplant recipients. This will include adverse effects of cigarette smoking on graft and patient survival, cardiovascular events, rejection, infections, and cancers in kidney transplant recipients. Lastly, the impact of kidney transplantation on behavior and smoking cessation will also be discussed.

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Section: Cigarette Smoking and Kidney Donorsmentioning

confidence: 99%

“…Kidney transplantation is in fact an incentive for patients to stop cigarette smoking. Keles and his colleagues [ 30 ] reported that preoperative cigarette smoking status in live donors was 47%. Postoperatively, it reduced significantly to 29%.…”

Section: Effect Of Kidney Transplantation On Cigarette Smoking Behmentioning

confidence: 99%

Cigarette Smoking and Its Hazards in Kidney Transplantation

Khalil¹,

Tan

Khamis³

et al. 2017

Advances in Medicine

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show abstract

“…There are few studies evaluating smoking behavior of kidney donors. Kelles et al reported that 47% of donors had a history of smoking before nephrectomy, with 29% quitting smoking 12 months later (p = 0.001); however, their levels of nicotine dependence remained similar to those who continued smoking 26 .…”

Section: Discussionmentioning

confidence: 99%

Short- and Mid- Term Impact of Tobacco Smoking on Donor Renal Function Following Living Kidney Donation at a Tertiary Referral Hospital

Kauffman-Ortega¹,

Martínez-Delgado²,

Garza-Gangemi³

et al. 2021

RIC

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Background:The negative impact of tobacco smoking on renal function has been widely studied. However, there is limited knowledge about the effect of smoking on pre-operative and post-operative renal function in living kidney donors. Objective:The objective of the study was to evaluate the short-and mid-term impact of smoking on donor renal function. Methods: This is a retrospective study of 308 patients who underwent living donor nephrectomy (LDN) at a tertiary referral hospital. We compared baseline characteristics as well as functional outcomes following LDN according to history of tobacco smoking. Estimated glomerular filtration rate (eGFR) was calculated with the modification of diet in renal disease equation in 6 time periods: pre-operative, 1 week, 1 month, 6 months, 12 months, and 24 months after surgery. We performed a Kaplan-Meier analysis for chronic kidney disease (CKD) outcome and binary logistic regression analysis to identify risk factors associated with CKD at 24 months of follow-up. Results: Among donors, 106 (34.4%) reported a smoking history before nephrectomy. Smoking donors had worse pre-operative eGFR than non-smokers (90 ± 26.3 mL/min/1.73m 2 vs. 96 ± 27 mL/min/1.73 m 2 , respectively; p = 0.02) and lower eGFR at 1 week (p = 0.01), 1 month (p ≤ 0.01), 6 months (p = 0.01), and 12 months (p = 0.01) after LDN. Tobacco smoking (OR 3.35, p ≤ 0.01) and age ≥ 40 years at donation (OR 6.59, p ≤ 0.01) were associated with post-operative development of CKD at 24 months after LDN. Conclusions: Living kidney donors with a tobacco smoking history had an increased risk of developing chronic kidney disease following nephrectomy. Smoking-cessation strategies should be implemented. (REV INVEST CLIN. [AHEAD OF PRINT]

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“…10,11 However, although it causes cardiovascular disease and cancer, smoking is not considered a con traindication for surgical procedures. 12 Because complete smoking history was insufficient in this study, cancer and cardiovascular diseases could not be assessed. Renal transplant recipients must be given support programs to help with quitting smoking.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2016

Exp Clin Transplant

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Objectives: Smoking is the most important remediable risk factor for the progression of renal diseases. Smoking has serious adverse effects, such as cardiovascular disease, kidney function impairment, and cancer in kidney transplant recipients who are already at high risk for these diseases. In this study, our objective was to evaluate descriptive characteristics and smoking status of renal transplant recipients. Materials and Methods: We evaluated 113 patients who underwent renal transplant at Baskent University Hospital between 1990 and 2015. The medical records of all patients were retrospectively reviewed. Patient demographics, cause of renal diseases, mortality status, smoking status, and amount of smoking were recorded. Results: In our study, 82 patients (72.7%) were male and 31 were female. The mean age was 38.50 ± 12.94 years. Causes of renal failure were as follows: 15.9% from hypertension, 12.4% from diabetes mellitus (all types), 8% from glomerulonephritis, 8% from vesicoureteral reflux, 6.2% from polycystic kidney disease, 17.6% other, and 31.9% unknown. Comorbid systemic disease was found in 57.6% of the patients. Fifty patients (44.2%) were current smokers, and 63 patients (55.8%) were nonsmokers. Mean age of smokers was 44.68 ± 10.60 years, with most being male patients (92.0%). There was a statistically significant difference between smoking status and sex (P < .001). The presence of comorbid diseases was significantly different between smokers and nonsmokers (P = .001). The smoking status of patients with hypertension (28.2%) was significantly different (P = .032) than others. Conclusions:Smoking cessation is associated with substantial health benefits for all smokers. For kidney transplant recipients, cigarette smoking has many adverse effects, causing cardiovascular disease and other comorbid diseases. Therefore, every attempt should be made to encourage kidney transplant candidates to stop smoking. Key words: Renal diseases, Smoking, Transplantation IntroductionSmoking is the most important risk factor in the progression of the renal diseases that can be corrected. In chronic renal diseases, cutting down on smoking is the most important factor in decreasing kidney malfunction. 1 Renal transplant recipients have a higher death rate related to diseases of cardiovascular origin than healthy individuals. 2 Smoking itself can be the main reason for cardiovascular mortality in renal transplant patients. Although chronic smoking increases proteinuria, it decreases renal plasma flow. 3 Although many argue that the nephrotoxic effects of smoking also affect renal transplant recipients, studies are scarce regarding the relation between smoking history and smoking habits and the smoking behaviors of patients on renal transplant wait lists. 2 The effect of smoking on the lifespan of renal transplant recipients has been evaluated by a limited number of studies. Because of cardiovascular diseases due to smoking, transplant recipients who smoke have a shorter lifespan. It is known that smoking befor...

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Effect of Kidney Transplantation on Smoking Habits of Kidney Donors

Cited by 5 publications

References 14 publications

Cigarette Smoking and Its Hazards in Kidney Transplantation

Cigarette Smoking and Its Hazards in Kidney Transplantation

Short- and Mid- Term Impact of Tobacco Smoking on Donor Renal Function Following Living Kidney Donation at a Tertiary Referral Hospital

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