Effect of Ketoprofen Co-Administration and Febrile State on Pharmacokinetics of Levofloxacin in Goats Following Intravenous Administration

Jatin, H. Patel; Priti, D. Vihol; Kamlesh, A. Sadariya; Urvesh, D. Patel; Rasesh, D. Varia; Shailesh, Koradia; Ashwin, M. Thaker

doi:10.20546/ijcmas.2018.710.287

Cited by 3 publications

(1 citation statement)

References 18 publications

(14 reference statements)

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“…Antibacterial and anti-inflammatory are used most frequently in multiple drug prescriptions. It is documented that concurrently administered of both types of drugs may alter pharmacokinetics of one another (Patel et al 2018). Standalone use of antibiotics is not effective to alleviate the inflammatory changes.…”

Section: Therapeutic Regime Of Anti-microbial and Anti-inflammatory U...mentioning

confidence: 99%

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

2023

Int J Vet Sci

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Pneumonia is the inflammation of lung parenchyma due to various organisms resulting in numerous manifestations and sequelae. The environment in the tropical regions provides optimal conditions for infection to occur in small ruminants. Mannheimiosis caused by Mannheimia haemolytica is the most frequent isolated bacteria causing pneumonia in small ruminants. The bacteria may cause an acute infection which can lead to death without proper diagnosis and treatment. To date, there are still scarce study on the effect of anti-microbial and anti-inflammatory treatments on reproductive physiology that warrants investigation. Hence, this review paper aims to focus on the possible effect of a combined usage of anti-microbial and anti-inflammatory treatments toward male reproductive physiology.

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Section: Therapeutic Regime Of Anti-microbial and Anti-inflammatory U...mentioning

confidence: 99%

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

2023

Int J Vet Sci

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Levofloxacin in veterinary medicine: a literature review

Sitovs

Sartini

Giorgi

2021

Research in Veterinary Science

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Original article Pretreatment with trikatu augments pharmacokinetic profile and bioavailability of orally administered levofloxacin in goat

Patel¹,

Vihol²,

Sadariya³

et al. 2019

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Pharmacokinetics of levofloxacin in goats, following oral administration (4 mg/kg) was evaluated in trikatu pretreated goats. Reverse-phase High Performance Liquid Chromatography (HPLC) was applied for determination of levofloxacin concentration in plasma concentration. Maximum plasma concentration (C max ), elimination halflife (t 1/2 ), volume of distribution (Vd area ), total body clearance (Cl B ) and bioavailability were 0.60 ± 0.03 g/ml, 0.95 ± 0.07 h, 1.91 ± 0.11 l/kg, 1.06 ± 0.06 l/h/kg and 21.49 %, respectively observed after oral administration of levofloxacin in goats. In trikatu pretreated goats, pharmacokinetic parameters, viz., maximum plasma concentration (C max ), elimination half-life (t 1/2 ), volume of distribution (Vd area ), total body clearance (Cl B ) and bioavailability were reported as 0.74 ± 0.03 g/ml, 2.07 ± 0.15 h, 2.98 ± 0.26 l/kg, 1.02 ± 0.04 l/h/kg and 30.16 %, respectively. In conclusion, significant difference was observed in majority of pharmacokinetic data of levofloxacin in trikatu pretreated goats than those in normal goats. Trikatu pretreatment in goats significantly increased bioavailability of levofloxa cin.

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Effect of Ketoprofen Co-Administration and Febrile State on Pharmacokinetics of Levofloxacin in Goats Following Intravenous Administration

Cited by 3 publications

References 18 publications

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

Levofloxacin in veterinary medicine: a literature review

Original article Pretreatment with trikatu augments pharmacokinetic profile and bioavailability of orally administered levofloxacin in goat

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