Effect of ketogenic diet versus regular diet on voice quality of patients with Parkinson’s disease

Koyuncu, Handan; Fidan, Vural; Toktaş, Hayal Ergin; Binay, Omer; Çelik, Hamit

doi:10.1007/s13760-020-01486-0

Cited by 20 publications

(28 citation statements)

References 21 publications

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“…In a pilot study, five patients were able to prepare a ketogenic diet and adhere to it for 4 weeks, which lead to significant improvement in the Unified Parkinson's Disease Rating Scale scores [112]. Further, when compared to a regular diet, a ketogenic diet for 3 months improved the voice handicap index in PD patients [113]. Phillips et al [114] randomized patients with PD to 8 weeks of a ketogenic diet versus a low-fat, high-carbohydrate diet.…”

Section: Ketone Bodies In Other Neurodegenerative Diseasesmentioning

confidence: 99%

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Jensen

Wodschow

Nilsson

et al. 2020

IJMS

248

181

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Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during prolonged fasting, ketone bodies become an important energy source for the brain. The brain’s utilization of ketones seems to depend mainly on the concentration in the blood, thus many dietary approaches such as ketogenic diets, ingestion of ketogenic medium-chain fatty acids or exogenous ketones, facilitate significant changes in the brain’s metabolism. Therefore, these approaches may ameliorate the energy crisis in neurodegenerative diseases, which are characterized by a deterioration of the brain’s glucose metabolism, providing a therapeutic advantage in these diseases. Most clinical studies examining the neuroprotective role of ketone bodies have been conducted in patients with Alzheimer’s disease, where brain imaging studies support the notion of enhancing brain energy metabolism with ketones. Likewise, a few studies show modest functional improvements in patients with Parkinson’s disease and cognitive benefits in patients with—or at risk of—Alzheimer’s disease after ketogenic interventions. Here, we summarize current knowledge on how ketogenic interventions support brain metabolism and discuss the therapeutic role of ketones in neurodegenerative disease, emphasizing clinical data.

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Section: Ketone Bodies In Other Neurodegenerative Diseasesmentioning

confidence: 99%

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Jensen

Wodschow

Nilsson

et al. 2020

IJMS

248

181

View full text Add to dashboard Cite

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“…A pilot study indicated that the Unified Parkinson’s Disease Rating Scale (UPDRS) scores were improved after five patients with PD adhered to a KD for 28 days [ 186 ]. Additionally, a 3-month KD increased the voice quality of patients, as evaluated by the voice handicap index of patients with PD [ 187 ]. In another pilot randomized controlled trial, 47 patients with PD were randomly assigned to a KD group and a low-fat group over 8 weeks, and the primary outcomes of motor and non-motor symptoms were assessed by the International Parkinson and Movement Disorder Society-sponsored UPDRS (MDS-UPDRS).…”

Section: Effects Of Kd On Normal Brain Aging and Neurodegenerative Di...mentioning

confidence: 99%

Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases

et al. 2022

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The ketogenic diet (KD) is a low-carbohydrate, high-fat and adequate-protein diet. As a diet mimicking fasting, it triggers the production of ketone bodies (KBs) and brings the body into a state of ketosis. Recent and accumulating studies on humans and animal models have shown that KD is beneficial to neurodegenerative diseases through modulating central and peripheral metabolism, mitochondrial function, inflammation, oxidative stress, autophagy, and the gut microbiome. Complicated interplay of metabolism, gut microbiome, and other mechanisms can regulate neuroinflammation in neurodegenerative diseases by activating multiple molecular and cellular pathways. In this review, we detail the physiological basis of the KD, its functions in regulating neuroinflammation, and its protective role in normal brain aging and neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). We aimed to elucidate the underlying neuroinflammatory mechanisms of KD therapies in neurodegenerative diseases and provide novel insights into their application for neurodegenerative disease prevention and treatment.

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“…Energy intake varied between studies; most reported ad libitum food intake or intake formulated for weight maintenance (n = 43), eight had mild-to-moderate calorie restriction (27,37,43,44,47,68,79,81) , six were very low-calorie (<800 kcal per day) (52,53,57,72,76,77) , three had combined protocols (51,71,73) and did not specify energy intake (56,67,70) . Weight loss prepost intervention was common (n = 45), but not always significant.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Weight loss prepost intervention was common (n = 45), but not always significant. Five studies reported no weight loss (26,32,36,38,48) , and nine did not report weight changes (25,45,53,56,63,64,67,70,83) .…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Low-carbohydrate and ketogenic diets: a scoping review of neurological and inflammatory outcomes in human studies and their relevance to chronic pain

Field

Pourkazemi

et al. 2022

Nutr. Res. Rev.

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Dietary restriction of carbohydrate has been demonstrated to be beneficial for nervous system dysfunction in animal models and may be beneficial for human chronic pain. The purpose of this review is to assess the impact of a low-carbohydrate/ketogenic diet on the adult nervous system function and inflammatory biomarkers to inform nutritional research for chronic pain. An electronic data base search was carried out in May 2021. Publications were screened for prospective research with dietary carbohydrate intake <130g/day and duration of ≥2 weeks. Studies were categorised into those reporting adult neurological outcomes to be extracted for analysis and those reporting other adult research outcomes Both groups were screened again for reported inflammatory biomarkers. From 1548 studies there were 847 studies included. Sixty-four reported neurological outcomes with 83% showing improvement. Five hundred and twenty-three studies had a different research focus (metabolic n=394, sport/performance n=51, cancer n=33, general n=30, neurological with non-neuro outcomes n=12, or gastrointestinal n=4). The second screen identified 63 studies reporting on inflammatory biomarkers with 71% reporting a reduction in inflammation. The overall results suggest a favourable outcome on the nervous system and inflammatory biomarkers from a reduction in dietary carbohydrates. Both nervous system sensitisation and inflammation occur in chronic pain and the results from this review indicate it may be improved by low-carbohydrate nutritional therapy. More clinical trials within this population are required to build on the few human trials that have been done.

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Effect of ketogenic diet versus regular diet on voice quality of patients with Parkinson’s disease

Cited by 20 publications

References 21 publications

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases

Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases

Low-carbohydrate and ketogenic diets: a scoping review of neurological and inflammatory outcomes in human studies and their relevance to chronic pain

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