Abstract:Surgery is now the main clinical treatment for hemorrhoids, and the procedure for prolapse and hemorrhoids (PPH) is the commonly used procedure. The key to evaluating the efficacy of surgery includes the quality of postoperative wound healing and the occurrence of complications, so it is especially important to enhance the postoperative rehabilitation of hemorrhoids. This study investigates the method of postoperative treatment with Kangfuxin solution fumigation bath to explore the role of this method in the e… Show more
“…9 studies had low risk of bias, 3 studies had some concerns of bias risk and 2 studies had high of bias risk. The risk of bias occurring during the randomization process had some concerns in 4 studies [ 16 , 18 , 21 , 29 ] due to an uncertain randomization sequence, 1 study [ 24 ] did not mention blinding methods and 1 study [ 27 ] was categorized as having a high risk of measurement of the outcome because therapists knew the group they were treating. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…This is because after surgery, especially excisional haemorrhoidectomy, postoperative pain, which generally results from a spasm of the internal anal sphincter, causes many issues for patients [ 2 ]. For the treatment of postoperative pain in patients after haemorrhoidectomy, people often choose different methods, such as sitz baths [ 29 ], medications to reduce swelling [ 32 ] or topical anaesthesia [ 33 ]. Chemical sphincterotomy, which is always used for patients with anal fissures, can reduce spasms of the internal anal sphincter and relieve pain [ 34 ].…”
Purpose
This study aims to evaluate the pain relief function of chemical sphincterotomy in patients undergoing haemorrhoid surgery and compare, through a meta-analysis, the different drugs used to treat this condition.
Methods
We conducted a search in databases including PubMed, EMBASE and Web of Science. The methodological quality was evaluated using the Revised Cochrane risk-of-bias tool for randomized trials (ROB2). The pain score was assessed using a visual analogue scale (VAS) on day 1, day 2, and day 7, and a meta-analysis was conducted based on the use of random effects models. In addition, the subgroup analysis was evaluated based on the kind of experimental drugs. Heterogeneity and publication bias were assessed.
Results
Fourteen studies with a total of 681 patients were included in this meta-analysis, and all studies were randomized controlled trials RCTs. Chemical sphincterotomy showed better pain relief function than placebo on day 1 (SMD: 1.16, 95% CI 0.52 to 1.80), day 2 (SMD: 2.12, 95% CI 1.37 to 2.87) and day 7 (SMD: 1.97, 95% CI 1.17 to 2.77) after surgery. In the subgroup meta-analysis, we found that different drugs for chemical sphincterotomy provided different pain relief.
Conclusion
Chemical sphincterotomy effectively relieves pain after haemorrhoidectomy, and calcium channel blockers have the best effect.
“…9 studies had low risk of bias, 3 studies had some concerns of bias risk and 2 studies had high of bias risk. The risk of bias occurring during the randomization process had some concerns in 4 studies [ 16 , 18 , 21 , 29 ] due to an uncertain randomization sequence, 1 study [ 24 ] did not mention blinding methods and 1 study [ 27 ] was categorized as having a high risk of measurement of the outcome because therapists knew the group they were treating. Fig.…”
Section: Resultsmentioning
confidence: 99%
“…This is because after surgery, especially excisional haemorrhoidectomy, postoperative pain, which generally results from a spasm of the internal anal sphincter, causes many issues for patients [ 2 ]. For the treatment of postoperative pain in patients after haemorrhoidectomy, people often choose different methods, such as sitz baths [ 29 ], medications to reduce swelling [ 32 ] or topical anaesthesia [ 33 ]. Chemical sphincterotomy, which is always used for patients with anal fissures, can reduce spasms of the internal anal sphincter and relieve pain [ 34 ].…”
Purpose
This study aims to evaluate the pain relief function of chemical sphincterotomy in patients undergoing haemorrhoid surgery and compare, through a meta-analysis, the different drugs used to treat this condition.
Methods
We conducted a search in databases including PubMed, EMBASE and Web of Science. The methodological quality was evaluated using the Revised Cochrane risk-of-bias tool for randomized trials (ROB2). The pain score was assessed using a visual analogue scale (VAS) on day 1, day 2, and day 7, and a meta-analysis was conducted based on the use of random effects models. In addition, the subgroup analysis was evaluated based on the kind of experimental drugs. Heterogeneity and publication bias were assessed.
Results
Fourteen studies with a total of 681 patients were included in this meta-analysis, and all studies were randomized controlled trials RCTs. Chemical sphincterotomy showed better pain relief function than placebo on day 1 (SMD: 1.16, 95% CI 0.52 to 1.80), day 2 (SMD: 2.12, 95% CI 1.37 to 2.87) and day 7 (SMD: 1.97, 95% CI 1.17 to 2.77) after surgery. In the subgroup meta-analysis, we found that different drugs for chemical sphincterotomy provided different pain relief.
Conclusion
Chemical sphincterotomy effectively relieves pain after haemorrhoidectomy, and calcium channel blockers have the best effect.
“…After a systematic search and screening of the Chinese and English databases, 15 studies that met the inclusion and exclusion criteria were included in this study [ [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] ]. Fig.…”
“…Some infants with severe ACC require skin grafting to prevent bleeding and infection (18,19). Kangfuxin solution (Periplaneta americana L. extract) is used for trauma wounds, ulcers, fistulas, burns, scalds, and bedsores (20,21). The current authors combined recombinant human epidermal growth factor gel with kangfuxin solution in an external application to successfully treat a scalp defect wound.…”
BackgroundAplasia cutis congenita is a congenital disorder with the absence of skin, muscle and(or) bone. It usually affects the scalp. The presence of a large scalp defect can be potentially serious when complicated with hemorrhage and infection. Early healing of this condition is beneficial to improve the prognosis of infants.Study caseA full-term newborn male was born with a round-shaped defect at the vertex of the scalp and skull (dimensions, 8 cm × 9 cm). The infant had a large deletion encompassing the 15.1 region of chromosome 15, including the DLL4 gene. Genetic testing was positive for Adams–Oliver syndrome (AOS). After two months of recombinant human epidermal growth factor gel combined with kangfuxin solution therapy, the skin defects of the scalp healed remarkably. The infant had regular follow-up appointments. At the age of 5 months, the defect became smaller, hairless, and showed good granulation tissue. At 2 years of age, the child's Gesell Developmental Schedules was 70.ConclusionRecombinant human epidermal growth factor gel combined with kangfuxin solution was a successful conservative treatment for an infant with a large scalp defect accompanied by AOS.
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