Effect of Jiangan‐Jiangzhi Pill on Gut Microbiota and Chronic Inflammatory Response in Rats with Non‐Alcoholic Fatty Liver

Zhao, Zeyu; Wang, Jing; Ren, Wei; Bian, Yuhong; Wang, Yixi; Wang, Li; Guo, Liying; Lei, Jinyan; Jia, Jianwei; Miao, Jing

doi:10.1002/cbdv.202100987

Cited by 6 publications

(4 citation statements)

References 51 publications

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“…This change was also observed in the CoM and PC groups, but unlike the CaM group, NAFLD was not alleviated in the CoM group mice. The results of this study are similar to those of Wang and Zhao et al ( 6 , 59 ). At the genus level, Bacteroides is an important component of the intestinal flora and has an important impact on health.…”

Section: Discussionsupporting

confidence: 92%

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Hao

Liang

et al. 2022

Front. Nutr.

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Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease of life, usually caused by unhealthy diet and lifestyle. Compared to normal individuals, the structure of the intestinal flora of NAFLD patients is altered accordingly. This study investigates the effect of camel milk on the regulation of intestinal flora structure in mice with high-fat diet-induced NAFLD. NAFLD model was established by feeding C57BL/6J mice a high-fat diet for 12 weeks, meanwhile camel milk (3.0 g/kg/d), cow milk (3.0 g/kg/d), and silymarin (200 mg/kg/d) were administered by gavage, respectively. Food intake and changes of physiological indexes in mice were observed and recorded. The 16S rRNA gene V3-V4 region was sequenced and the intestinal flora diversity and gene function were predicted in the colon contents of mice from different group. The results showed that camel milk enhanced glucolipid metabolism by downregulate the levels of blood glucose and triglyceride (TG) in serum, reduced lipid accumulation by downregulate the level of TG in the liver and improved liver tissue structure in NAFLD mice (p < 0.05). Meanwhile, camel milk had a positive modulatory effect on the intestinal flora of NAFLD mice, increasing the relative abundance of beneficial bacteria and decreasing the relative abundance of harmful bacteria in the intestinal flora of NAFLD mice, and silymarin had a similar modulatory effect. At the genus level, camel milk increased the relative abundance of Bacteroides, norank_f_Muribaculaceae and Alloprevotella and decreased the relative abundance of Dubosiella and Coriobacteriaceae_UCG-002 (p < 0.05). Camel milk also enhanced Carbohydrate metabolism, Amino acid metabolism, Energy metabolism, Metabolism of cofactors and vitamins and Lipid metabolism in NAFLD mice, thus reducing the degree of hepatic lipid accumulation in NAFLD mice and maintaining the normal structure of the liver. In conclusion, camel milk can improve the structure and diversity of intestinal flora and enhance the levels of substance and energy metabolism in NAFLD mice, which has a positive effect on alleviating NAFLD and improving the structure of intestinal flora.

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Section: Discussionsupporting

confidence: 92%

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Hao

Liang

et al. 2022

Front. Nutr.

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“…The ratio of Firmicutes and Bacteroidetes in the FLD group was higher than that in the healthy group. Accumulation of TG over 5% of the total liver weight is characteristic of NAFLD [ 63 ]. We speculate that TG may be a key node in the clinical indicator microbial network of children with NAFLD due to the NAFLD itself.…”

Section: Discussionmentioning

confidence: 99%

Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease

Liang

Zunong

et al. 2022

Nutrients

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Abnormally high lymphocyte counts are seen in persons with nonalcoholic fatty liver disease (NAFLD). Gut microbiota dysbiosis is a risk factor for NAFLD. We assessed the gut microbiota of 63 healthy children and 63 children with NAFLD using 16S rRNA gene and metagenomic sequencing to explore the relationships. Compared with healthy children (HC group), the Bacteroidetes, Verrucomicrobia, and Akkermansia were less abundant, while the Actinobacteria were more abundant in children with NAFLD (FLD group). To understand the effect of lymphocytes on the gut microbiota of children with NAFLD, we compared the microbiota of 41 children with NAFLD and high numbers of lymphocytes (FLD_HL group) and 22 children with NAFLD and low numbers of lymphocytes (FLD_LL group). The abundances of Bacteroidetes, Verrucobacterium, and Akkermansia increased and Actinobacteria decreased in the FLD_LL group compared to the FLD_HL group. Akkermansia was negatively correlated with lymphocyte count. NAFLD may disturb the gut microbiota in children through reducing the abundance of Akkermansia and increasing the abundance of proinflammatory bacteria, such as Escherichia-Shigella. Conclusions: High lymphocyte counts are associated with disturbances of gut microbiota and emergence of opportunistic pathogens in children with NAFLD.

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Section: Intestinal Flora and Metabolic Diseasesmentioning

confidence: 99%

“…In addition, Chinese medicine ingredients and preparations of resveratrol, phytosterol esters, black fungus polysaccharides, Fuzhuan tea, Simiao prescription, and Jiangan Jiangzhi pills can improve NAFLD by regulating intestinal flora disorder. [58][59][60][61][62][63] Intestinal Flora and Immune System Diseases Asthma Asthma is a type I hypersensitivity disease. After exposure to allergens, atopic individuals induce mast cells and basophils to degranulate, causing them to release active mediators such as prostaglandins, histamine, and leukotrienes, triggering bronchospasm and impaired pulmonary ventilation.…”

Section: Diabetesmentioning

confidence: 99%

Research Progress of Intestinal Flora and Related Diseases

Sun,

Zhang,

Zhang

et al. 2023

Chinese medicine and natural products

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The intestinal tract is an important digestive organ and detoxification organ of the human body, and its circling structure is vividly called the “second brain” of the human body. There are hundreds of millions of bacterium in the intestinal tract. These bacteria live in mutual benefit with the body, provide energy and nutrients for the host and themselves through fermented food, participate in the metabolism of the body, and form a metabolic mode of cometabolism between the host and the symbiotic flora. In addition, intestinal flora can also help the body resist the invasion of pathogens, promote human health, and resist diseases. More and more studies have shown that when the body is subjected to exogenous or endogenous stimuli, the microbial flora in the intestinal will change, and the disturbance of intestinal flora is closely related to the occurrence and development of inflammatory bowel diseases, metabolic diseases, immune system diseases, mental system diseases, and tumors. This article reviews the research progress of the intestinal flora affecting the pathogenesis of various diseases, aiming to provide new references and ideas for the clinical treatment of diseases.

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Effect of Jiangan‐Jiangzhi Pill on Gut Microbiota and Chronic Inflammatory Response in Rats with Non‐Alcoholic Fatty Liver

Cited by 6 publications

References 51 publications

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease

Interplay of Lymphocytes with the Intestinal Microbiota in Children with Nonalcoholic Fatty Liver Disease

Research Progress of Intestinal Flora and Related Diseases

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