Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non‐controlled study

Karadağ, Ayşe Serap; Tutal, Emre; Ertuğrul, Derun Taner; Akın, Kadir Okhan

doi:10.1111/j.1365-4632.2011.05027.x

Cited by 28 publications

(36 citation statements)

References 31 publications

(91 reference statements)

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“…It has been hypothesized that vitamin B 12 modulates the activities of the skin microbiota and contributes to AV pathogenesis [26]. On the other hand, reports have linked vitamin B 12 deficiency to the treatment of AV by isotretinoin [27]. In our data, there was no association between levels of vitamin B 12 and AV in univariable nor multivariable analysis.…”

Section: Discussioncontrasting

confidence: 74%

Predictors of Acne Vulgaris among Adolescents in Kuwait

AlKhabbaz¹,

Al-Taiar²,

Saeed³

et al. 2019

Med Princ Pract

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Objectives: The prevalence of acne vulgaris (AV) among adolescents in Kuwait has remained mostly unknown. This study aimed to estimate the prevalence of AV and its predictors among adolescents in Kuwait. Subjects and Methods: A cross-sectional study was conducted on 714 participants who were randomly selected from public schools using multistage cluster random sampling. The presence or absence of AV, as well as severity of AV, were assessed using the Global Acne Grading Scale. Data on risk factors and potential confounders were collected from the parents through a self-administered questionnaire, and from the adolescents by face-to-face interview. Weight and height were measured in a standardized manner. Results: Of 714 participants, 320 (44.8%; 95% CI 41.1–48.6%) self-reported AV. By clinical examination, AV was found among 479 (67.1%; 95% CI 63.5–70.5%) participants. Factors that were found to be significantly associated with AV in multivariable analysis were age, gender, nationality, and BMI categories. Females compared to males (adjusted prevalence ratio [APR] 1.16 [95% CI 1.05–1.25]; p = 0.006) and overweight or obese adolescents compared to normal weight (APR 1.15 [95% CI 1.02–1.26] and 1.14 [95% CI 1.02–1.23], respectively; p = 0.026) were more likely to have AV. None of the food items studied showed an association with AV in multivariable analysis. Conclusion: The prevalence of self-reported AV seems to be lower than that reported in other settings, while the prevalence of AV by clinical examination resembles that reported in many other countries. BMI was the only modifiable risk factor associated with AV in multivariable analysis, and none of the food items studied was related to the presence or absence of AV in multivariable analysis.

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Section: Discussioncontrasting

confidence: 74%

Predictors of Acne Vulgaris among Adolescents in Kuwait

AlKhabbaz¹,

Al-Taiar²,

Saeed³

et al. 2019

Med Princ Pract

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“…Prolactin receptor (PRLR) was profoundly downregulated which is in line with a study in patients with acne where isotretinoin caused suppression of several pituitary hormones such as prolactin in patients' sera [58].…”

Section: Regulation Of Development Genes By Rasupporting

confidence: 83%

Transcriptional changes in organoculture of full‐thickness human skin following topical application of all‐trans retinoic acid

Gillbro

Al-Bader

Westman

et al. 2014

Intern J of Cosmetic Sci

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SynopsisObjectiveRetinoids are used as therapeutic agents for numerous skin diseases, for example, psoriasis, acne and keratinization disorders. The same substances have also been recognized in the treatment for hyperpigmentation disorders such as melasma.Other studies on photo-damaged skin have shown that retinoids reduce wrinkles, surface roughness, mottled pigmentation, and visual skin appearance as a whole. We tested the hypothesis that an organoculture of full-thickness human skin could be used as a preclinical model to investigate the retinoid transcriptional profile in human skin in vitro.MethodsFull-thickness skin explants were exposed to topically applied all-trans retinoic acid (RA) for 24 h. The gene expression profile was analysed using oligonucleotide microarrays, and data were validated with real-time (RT) PCR.ResultsWe showed that the expression of 93 genes was significantly altered more than twofold. Several of the altered genes, for example, KRT4, CYP26 and LCN2, have previously been shown to be affected by RA in keratinocyte monocultures, reconstructed epidermis and skin biopsies from patients treated topically or orally with RA. In addition, genes, such as SCEL, NRIP1, DGAT2, RDH12 EfnB2, MAPK14, SAMD9 and CEACAM6 not previously reported to be affected by RA in human skin, were identified for the first time in this study.ConclusionThe results in the present study show that full-thickness human explants represent a valuable pre-clinical model for studying the effects of retinoids in skin.RésuméObjectifLes rétinoïdes sont utilisés comme agents thérapeutiques pour de nombreuses maladies de la peau, p.ex. le psoriasis, l'acné et les troubles de la kératinisation. Les mêmes substances ont également été reconnues dans le traitement des troubles de l' hyperpigmentation tels que le melasma.D'autres études sur la peau photo-endommagée ont montré que les rétinoïdes réduisent les rides, la rugosité de la surface, la pigmentation tachetée, et l'aspect visuel de la peau dans son ensemble. Nous avons testé l'hypothèse selon laquelle une organoculture de épaisseur intégrale de la peau humaine pourrait être utilisée comme modèle préclinique pour étudier le profil transcriptionnel des rétinoïdes dans la peau humaine in vitro.MéthodesDes explants de peau intégrale ont été exposés à l'application topique de all-trans acide rétinoïque (RA) pendant 24 heures. Le profil d' expression des gènes a été analysé en utilisant des puces DNA array et les données ont été validées par (RT) -PCR.ResultatsNous avons montré que l'expression de 93 gènes a été modifiée de façon significative par plus d'un facteur 2. Plusieurs des gènes modifiés par exemple KRT4, CYP26 et LCN2 ont été montrés précédemment d'être affectés par RA dans les monocultures de kératinocytes, dans l'épiderme reconstruit et dans des biopsies cutanées de patients traités par voie topique ou par voie orale avec RA. En outre, des gènes tels que SCEL, NRIP1, DGAT2, RDH12 EfnB2, MAPK14, SAMD9 et CEACAM6 non signalés précédemment, sont touchés par RA dans la peau ...

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“…The current study was in continuation of several studies on the effect of isotritinoin on several biomarkers in the acne patients and found level of serum GGT, ALT, ALP , triglycerides, cholesterol , homocysteine were elevated after 3 months of the treatment and this results agree with other studies [Muhammad 2015, Polat 2008,, Vieira 2012,Fusun 2017, Hilal 2014 Although many studies reported alterations in serum transaminase and lipid levels, other studies reported no significant in the level of these parameters , such as Brito et al found no statistically significant changes in liver transaminase, TG levels following treatment withIsotretinoin.In another study by Javanbakht et al, serum levels of homocysteine was not elevated through treatment withIsotretinoin. The results showed a decrease in the serum level of folic acid , vitamin B 12 and vitamin B 7 after 3 months of treatment with Isotretinoin , this results in agreement with several studies [Muhammad 2015, Hilal 2014, Karadag 2011 , while disagrees withPolat 2008.…”

Section: Discussionsupporting

confidence: 90%

Effect of isotretinoin treatment on the levels of serumhomocysteine, vitamin B6, vitamin B7, vitamin B12 and folic acid and on sebum composition in patients with moderate to severe acne vulgaris.

2018

IJCTR

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Background:AcneVulgaris(AV) is related to the pilosebaceous follicle. It is considered as adolescent disorder which is characterized by formation of open and closed comedones, papules, pustules, nodules and cysts.Isotretinoin is the only systemic therapy, which has advantages of cure, but causes significant side effects at higher doses. Objective: The current study was conducted to evaluate serum homocysteine, vitamin B 6 , vitamin B 7 , vitamin B 12 and folic acid and on sebum composition after treatment with isotretinoin. Methods: This study was conducted on thirty patients with AV. Clinical and laboratory evaluations were conducted before the start of therapy, 6 weeks after, and 12 weeks after treatment.serumhomocysteine, vitamin B 6 , vitamin B 7 , vitamin B 12 , folic acid liver function tests, serum cholesterol and triglyceride , creatinine levels were tested as well assebum cholesterol and sebum squaleneSPSS 20 was used for statistical analysis. Results: The results of the study showed significant differences (p<0.05) in homocysteine, vitamin B 6 , vitamin B 7 , vitamin B 12 , folic acid, GGT, ALP, ALT, serum cholesterol, triglyceride, sebum cholesterol and sebum squalene and skin moisture levels, while there were no significant differences in skin temperature ,skin skin pH and creatinine. Conclusions:Evaluation of homocysteine, vitamin B 6 , vitamin B 7 , vitamin B 12 and folic acid beside the routine tests were beneficial for the patients before they started isotretinoin treatment.

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Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non‐controlled study

Cited by 28 publications

References 31 publications

Predictors of Acne Vulgaris among Adolescents in Kuwait

Predictors of Acne Vulgaris among Adolescents in Kuwait

Transcriptional changes in organoculture of full‐thickness human skin following topical application of all‐trans retinoic acid

Effect of isotretinoin treatment on the levels of serumhomocysteine, vitamin B6, vitamin B7, vitamin B12 and folic acid and on sebum composition in patients with moderate to severe acne vulgaris.

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