Effect of isoproterenol on regional pulmonary perfusion and its blockade by propranolol.

Effect of dopamine on regional pulmonary perfusion.

“…Isoproterenol reverted regional vasoconstriction in the right upper lobe (Isawa et al 1981), but this action was antagonized by propranolol (Isawa et al 1981). There was no such action in dopamine.…”

“…The right upper lobe of an anesthetized dog was isolated in vivo by a balloon catheter and artificially ventilated with nitrogen (N2), air or 60% oxygen (02) in nitrogen mixed with a trace amount of helium (He), while the rest of the lungs was breathing air spontaneously as reported previously (Isawa et al 1978a(Isawa et al , b, 1979(Isawa et al , 1980(Isawa et al , 1981. Each perfusion percentage in the right upper lobe when the lobe was artificially ventilated with N2, air and 60% 02 in N2, respectively was measured by a scintillation camera (RC-IC-1205, Hitachi Medical Corporation, Tokyo) after sequentially injecting 99mTc-albumin microsphere (TCK-5, SORIN, Salingia, Italy) as a tracer material.…”

“…The purpose of the present study was to elucidate the effect of dopamine administration on the regional pulmonary perfusion in a dog lung lobe which we have used to study regional perfusion changes under various conditions (Isawa et al 1978a(Isawa et al , b, 1979(Isawa et al , 1980(Isawa et al , 1981.…”

Effect of isoproterenol on regional pulmonary perfusion in the reimplanted lung of the dog.

“…The experimental procedures were the same as described previously (Isawa et al 1978a(Isawa et al ,, b, 1981. Especially the use of medications and the sequence of studies were the same as adopted in the normal dogs as reported previously (Isawa et al 1981) so that comparison of the data was possible between the normal and the denervated lung lobes. In brief, the right upper lobe was isolated by a balloon catheter under bronchoscopy and artificially ventilated with nitrogen (N2), air or 60% oxygen (02) in N2, while the rest of the lungs was spontaneously breathing air.…”

“…Propranolol per se did not alter genuine regional vascular responses to regional alveolar hypoxia or hyperoxia (Isawa et al 1981). …”