Effect of isoproterenol on force transient time course and on stiffness spectra in rabbit papillary muscle in barium contracture

Berman, Michael R.; Peterson, Jon N.; Yue, David T.; Hunter, William C.

doi:10.1016/s0022-2828(88)80133-0

Cited by 44 publications

(33 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Iso (0 1 /LM) increased the frequency of dip to 3-25+0 10 Hz (N = 4) ( Figs 4B and 5A). These results are compatible with those of previous reports which suggested an increase in the CCR by ,-adrenoceptor stimulation (Hoh et al 1988;Berman et al 1988;Saeki, Shiozawa, Yanagisawa & Shibata, 1990). The addition of ACh (1 yM) restored the Iso-altered K. HONGO, E. TANAKA AND S. KURIHARA frequency of dip to the control level (2-75+0-13 Hz, N = 4) ( Figs 4C and 5A).…”

Section: Changes In Cross-bridge Cycling Rate By Iso and A Chsupporting

confidence: 93%

“…,?-Adrenoceptor stimulation increased the CCR, as reported by Hoh et al (1988) and others (Berman et al 1988;Saeki et al 1990), and muscarinic receptor stimulation by ACh and carbachol restored the increased CCR (Fig. 5).…”

Section: Changes In Cross-bridge Cycling Rate By Iso and A Chsupporting

confidence: 80%

“…Yue & Hunter, 1988). In these studies, the stiffness during a steady-state tension level of Ba2+ contracture was measured, and the frequency at which the muscle stiffness becomes minimal (dip) was considered as the CCR.…”

Section: Changes In Cross-bridge Cycling Rate By Iso and A Chmentioning

confidence: 99%

See 2 more Smart Citations

Alterations in contractile properties and Ca2+ transients by beta‐and muscarinic receptor stimulation in ferret myocardium.

Hongo

Tanaka

Kurihara

1993

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. To clarify the mechanism which regulates the time course of twitch tension when /1-and muscarinic receptors are stimulated, intracellular Ca2+ transients, Ca21 sensitivity of the contractile element and the cross-bridge cycling rate (CCR) were measured in ferret ventricular muscles. 4. In order to measure CCR, the perturbation analysis method was applied to steady-state tension of tetanic contraction. The CCR was not altered even when the tetanic tension level was decreased to 50 % by decreasing [Ca2+]0. Iso (0-1 taM) slightly decreased the tetanic tension level and increased the CCR from 2 73 to 3 25 Hz. The effect of Iso was observed when the Iso-decreased tension was recovered by an increase in [Ca2+]i. The addition of ACh (1 /tM) recovered the CCR which was increased by Iso, to the control level. Atropine (10 yM) blocked the effect of ACh, and carbachol (1 /tM) restored the CCR increased by Iso to the control level.5. The time course of Ca21 transients, Ca2+ sensitivity and CCR were antagonistically regulated by fl-and muscarinic receptor stimulation, but the time course of tension did not parallel the changes in these parameters. Therefore, these results suggest that the time course of tension, particularly the relaxation time, is not determined by the time course of Ca2+ transients, Ca2+ sensitivity and the CCR, and that other factors might be involved in the regulation of the time course of tension when /3-and muscarinic receptors are stimulated.S98 26

show abstract

Section: Changes In Cross-bridge Cycling Rate By Iso and A Chsupporting

confidence: 93%

Section: Changes In Cross-bridge Cycling Rate By Iso and A Chsupporting

confidence: 80%

See 1 more Smart Citation

Alterations in contractile properties and Ca2+ transients by beta‐and muscarinic receptor stimulation in ferret myocardium.

Hongo

Tanaka

Kurihara

1993

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…In vertebrate muscle, 28,33) pioneered the use of complex stiffness and its dynamic decomposition to characterize the muscle fiber contractile state, to identify specific steps in the cross-bridge (XB) cycle, and to characterize the sensitivity of these steps to ATP and its metabolic products. They extended these methods to cardiac muscle (17,27,34), and their pioneering work has now been applied and extended by several other groups (2,3,6,13,19,21,26,29,32).One outcome of the work of Kawai et al (14,15) has been the routine practice of decomposing the measured dynamic stiffness into a sequence of first-order dynamic processes, each with increasing characteristic frequency (3,17,19,21,27,32,34). Thus dynamic stiffness is represented as the sum of component stiffnesses due to processes A, B, C, and so on, where process A, with characteristic frequency a, is slower than process B, with characteristic frequency b, which is slower than process C, with characteristic frequency c, and so on.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Interpreting cardiac muscle force-length dynamics using a novel functional model

Campbell

Chandra²,

Kirkpatrick³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

173

View full text Add to dashboard Cite

. Interpreting cardiac muscle force-length dynamics using a novel functional model. Am J Physiol Heart Circ Physiol 286: H1535-H1545, 2004; 10.1152/ ajpheart.01029.2003.-To describe the dynamics of constantly activated cardiac muscle, we propose that length affects force via both recruitment and distortion of myosin cross bridges. This hypothesis was quantitatively tested for descriptive and explanative validity. Skinned cardiac muscle fibers from animals expressing primarily ␣-myosin heavy chain (MHC) (mouse, rat) or ␤-MHC (rabbit, ferret) were activated with solutions from pCa 6.1 to 4.3. Activated fibers were subjected to small-amplitude length perturbations [⌬L(t)] rich in frequency content between 0.1 and 40 Hz. In descriptive validation tests, the model was fit to the ensuing force response [⌬F(t)] in the time domain. In fits to 118 records, the model successfully accounted for most of the measured variation in ⌬F(t) (R 2 range, 0.997-0.736; median, 0.981). When some residual variations in ⌬F(t) were not accounted for by the model (as at low activation), there was very little coherence (Ͻ0.5) between these residual force variations and the applied ⌬L(t) input function, indicating that something other than ⌬L(t) was causing the measured variation in ⌬F(t). With one exception, model parameters were estimated with standard errors on the order of 1% or less. Thus parameters of the recruitment component of the model could be uniquely separated from parameters of the distortion component of the model and parameters estimated from any given fiber could be considered unique to that fiber. In explanative validation tests, we found that recruitment and distortion parameters were positively correlated with independent assessments of the physiological entity they were assumed to represent. The recruitment distortion model was judged to be valid from both descriptive and explanative perspectives and is, therefore, a useful construct for describing and explaining dynamic force-length relationships in constantly activated cardiac muscle. muscle stiffness; cross-bridge recruitment; cross-bridge distortion; model validation; mouse; rat; ferret; rabbit MUSCLE LENGTH modulates cardiac muscle force development, and the resultant force-length relationship (FLR) is basic to the Frank-Starling mechanism of the heart. In general, however, muscle FLRs extend beyond the typical isometric twitching conditions under which force-length data are commonly collected to also include the force response to any length change during contraction. Thus descriptors of muscle FLR should also depict the dynamic force response to length changes that occur during contraction. One often-studied aspect of the dynamic FLR is the force response to sinusoidal length change in a constantly activated muscle fiber. Under these dynamic conditions, the amplitude and phase of the force response depends on both the frequency and amplitude of the sinusoidal length change. Dividing the steady-state sinusoidal force response by the sinusoidal length change yields...

show abstract

Regulation of Cardiac Contraction by Calcium

Moss

Buck

2002

Comprehensive Physiology

View full text Add to dashboard Cite

Effect of isoproterenol on force transient time course and on stiffness spectra in rabbit papillary muscle in barium contracture

Cited by 44 publications

References 25 publications

Alterations in contractile properties and Ca2+ transients by beta‐and muscarinic receptor stimulation in ferret myocardium.

Alterations in contractile properties and Ca2+ transients by beta‐and muscarinic receptor stimulation in ferret myocardium.

Interpreting cardiac muscle force-length dynamics using a novel functional model

Regulation of Cardiac Contraction by Calcium

Contact Info

Product

Resources

About