2012
DOI: 10.1016/j.transproceed.2012.07.056
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Effect of Ischemic Preconditioning on Injuries Caused by Ischemia and Reperfusion in Rat Intestine

Abstract: To study whether ischemic preconditioning (IPC) attenuated intestinal dysfunction caused by ischemia (I) and reperfusion (R), rats were underwent 60 minutes of I which was produced by occlusion of the superior mesenteric artery, and/or 120 minutes R. The IPC group had the I procedure previously stimulated for 5 minutes and the R for 10 minutes. IPC and sham groups were injected with saline solution (SS) via the femoral vein 5 minutes before the I and R, and for R. After I or I/R, 2-cm jejunal segments were mou… Show more

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Cited by 14 publications
(12 citation statements)
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References 32 publications
(29 reference statements)
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“…IPC is a strategy by which tissues are subjected to controlled periods of ischemia and reperfusion before prolonged IR injury and is considered a ubiquitous phenomenon in mammals. The actual mechanism by which an episode of brief ischemia and reperfusion in an organ or tissue exerts protection against a subsequent sustained ischemia-reperfusion injury in a remote organ or tissue is currently unclear [3][4][5][6][7][8][9][10][11]16,30 . In this research, the IPC procedures effectively protected the epithelial tissue and resulted in minimal smooth apical damage, minimal villous edema, and mildly dilated capillaries.…”
Section: ■ Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…IPC is a strategy by which tissues are subjected to controlled periods of ischemia and reperfusion before prolonged IR injury and is considered a ubiquitous phenomenon in mammals. The actual mechanism by which an episode of brief ischemia and reperfusion in an organ or tissue exerts protection against a subsequent sustained ischemia-reperfusion injury in a remote organ or tissue is currently unclear [3][4][5][6][7][8][9][10][11]16,30 . In this research, the IPC procedures effectively protected the epithelial tissue and resulted in minimal smooth apical damage, minimal villous edema, and mildly dilated capillaries.…”
Section: ■ Discussionmentioning
confidence: 99%
“…Ischemic preconditioning (IPC) is an intrinsic process whereby repeated short episodes of ischemia protect the organ against a subsequent prolonged ischemic insult [4][5][6][7] . Several reports have described the effects of IPC on the reduction of apoptosis of epithelial cells 4,5,[7][8][9] , structural protection 4,10,11 and preservation of intestinal contractility 10 . In brief, the IPC stimulus, made up of cycles of brief ischemia and reperfusion, initiates production of a number of autacoids (such as acetylcholine, adenosine, bradykinin, endothelin, and opioids) 11 .…”
mentioning
confidence: 99%
“…Ischemia-reperfusion injury (IRI) is a distinct clinical manifestation and affects many organs such as brain, heart, liver, kidney, and intestine 65-68. Initiated by ischemic injury, it enhances the production of reactive oxygen species (ROS), and causes calcium overload of intracellular and endothelial cells damage 69.…”
Section: The Protective Effect Of α7 Nicotinic Acetylcholine Receptormentioning
confidence: 99%
“…İnce bağırsaklar diğer iç organlar içinde İ/R hasarına en duyarlı organdır. İ/R hasarı hipovolemi, hipotansiyon ve sepsise yol açarak oksijen ve besin maddelerinin eksikliği ile intestinal motor ve sekretuar fonsiyonlarda kayba neden olmaktadır (2). Dokuya giden kan akımının kesilmesi sonrasında intrasellüler ATP düzeyinin azalması hücresel homeostazisi serbest oksijen radikalleri(SOR)'nin oluşumu ile bozar.…”
Section: Introductionunclassified