Effect of irradiation on the maturation of Wilms' tumor

Bannayan, George A.; Huvos, Andrew G.; D’Angio, Giulio J.

doi:10.1002/1097-0142(197104)27:4<812::aid-cncr2820270409>3.0.co;2-e

Cited by 64 publications

(16 citation statements)

References 8 publications

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“…In early lesions with well-differentiated epithelioid elements, the diagnosis of benign mesoblastic nephroma must be excluded, since these patients have an excellent prognosis.3 Maturation after irradiation of Wilms' tumor has been described. 1 Garcia et al' correlated the prognosis with the volume and extent of the tumor. In the At the Roswell Park Tumor Institute, 53y0 of 15 children with metastatic disease at the time of initial therapy survived 2 years without tumor, and 31y0 of 59 children with late metastatic disease survived 2 years without tumor after combined therapy."…”

Section: Discussionmentioning

confidence: 99%

Treatment of Wilms' tumor and factors affecting prognosis

Pérez

Kaiman

Keith

et al. 1973

Cancer

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Forty‐nine cases of Wilms' tumor treated at the Mallinckrodt Institute of Radiology and Children's Hospital, Washington University Medical Center, between 1950 and December 1969, were retrospectively analyzed. The most important prognostic factors were the anatomical stage of the tumor and some pathologic findings such as invasion of the renal capsule, the renal vein or inferior vena cava, and metastases to the regional lymph nodes or to other organs. A histopathologic classification based on differentiation of the tumor is presented and correlated with cure rates. Stage I lesions had a very good prognosis (85% 3‐year survival NED), even without high‐dose irradiation or prolonged chemotherapy. Triple therapy, involving nephrectomy, irradiation, and prolonged chemotherapy yielded a 55% survival rate in patients with Stage II and 30% in Stage IV (patients with pulmonary metastases). Stage III tumors showed an unsatisfactory response to this comprehensive approach. Patients with bilateral tumors are potentially curable if aggresively treated. From this study it can be concluded that: 1. thorough analysis of the clinical and pathologic characteristics of the tumor should be made in every case and management should be individualized, to avoid excessive treatment in early lesions with favorable prognosis, and 2. carefully administered postoperative irradiation and prolonged chemotherapy may improve the poor results in extensive lesions, even in the presence of distant metastases, with relatively minor sequelae in the surviving children. The late effects of vigorous and prolonged chemotherapy on the bone marrow, the immunologic surveillance system, and the germinal cells of the gonads as well as the repercussion on normal growth of these children remain to be evaluated.

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Section: Discussionmentioning

confidence: 99%

Treatment of Wilms' tumor and factors affecting prognosis

Pérez

Kaiman

Keith

et al. 1973

Cancer

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“…b Line drawing of structure depicted in a: internal enamel epithelium (In); external enamel epithelium (Ex); dental papilla (DP); stellate reticulum (SR); predentine (P) skeletal muscle and adipose tissue, this can be explained by the prior administration of chemo-and radiotherapy. Induction of differentiation in the primitive nonepithelial elements by irradiation and ablation of the more chemoand radiosensitive primitive tissues may be the reason for the absence of immature elements in the second neoplasm [1,9]. Similar reasoning would explain the predominance of heterologous elements in a recurrent WT.…”

Section: Discussionmentioning

confidence: 89%

Recurrent Wilms' tumour or retroperitoneal teratoma?

Govender

Hadley

1999

Virchows Archiv

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The clinical and pathological features of a left renal tumour and a subsequent retroperitoneal tumour in a 2-year-old boy are presented. The nephrectomy specimen showed typical features of a triphasic Wilms' tumour with focal heterologous elements and intralobar nephrogenic rests. The tumour was assessed as clinical stage III and post-operative chemotherapy and radiotherapy were administered. A retroperitoneal mass, detected following completion of postoperative therapy, was mainly made up of skeletal muscle and mature adipose tissue. Nests of epithelium resembling ameloblastic nests and a unique structure reminiscent of a developing tooth were present.

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“…Sukarochana and Kiesewetter (1966) noted that two out of their 62 children with Wilms' tumour developed bone metastases, but no mention of the histology in these cases is made. Bannayan et al (1971) found bone metastases in six children out of 55 with metastatic Wilms' tumour.…”

Section: Discussionmentioning

confidence: 93%

Bone metastases in children presenting with renal tumours.

Lawler¹,

Marsden²

1979

J Clin Pathol

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A survey of bone metastases in 132 children presenting with renal tumours has been carried out using material from the Manchester (England) Children's Tumour Registry during the period 1954 to 1976. Seven such cases were found. Only one of the 117 Wilms' tumours developed bone metastases. The remainder included carcinoma (1/4), 'bone metastasising renal tumour of childhood' (2/3), atypical tumours (2/2), and lymphosarcoma (1/1). Bone metastases from true nephroblastoma seem to be an exceptional finding.

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Effect of irradiation on the maturation of Wilms' tumor

Cited by 64 publications

References 8 publications

Treatment of Wilms' tumor and factors affecting prognosis

Treatment of Wilms' tumor and factors affecting prognosis

Recurrent Wilms' tumour or retroperitoneal teratoma?

Bone metastases in children presenting with renal tumours.

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