Effect of Iron on the Virulence of Trichomonas vaginalis

Ryu, Jae‐Sook; Choi, Hyun Ki; Min, Duk Young; Ha, S. E.; Ahn, Myoung-Hee

doi:10.2307/3285075

Cited by 36 publications

(38 citation statements)

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“…These proteins interact with host cells via ligand-receptor-type interactions [17]. Furthermore, it has been reported that transcription and expression of genes coding for these proteins are greatly influenced by iron concentration in the medium where the protozoan was cultivated [18][19][20]. Pathogenicity is also influenced by cellular contact between pathogens and the epithelial cells, culminating in disturbance of the junctional complex [14,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Trichomonas vaginalis perturbs the junctional complex in epithelial cells

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Trichomonas vaginalis perturbs the junctional complex in epithelial cells

et al. 2005

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“…The role of iron in T. vaginalis has been shown to be associated with the virulence of the parasite in mice [7]. In addition to the increased virulence, iron also enhances the level of adherence and the cytotoxicity of Trichomonads [7].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the increased virulence, iron also enhances the level of adherence and the cytotoxicity of Trichomonads [7].…”

Section: Discussionmentioning

confidence: 99%

“…Each group consisted of 48 microtubes containing 1.2 ml culture media and 10 µl media containing about 3000 T. vaginalis organism. In Iron-supplemented group, ferrous sulfate was also added to adjust a final Fe concentration on 400 µM [7]. Six microtubes from each group were removed and followed at 2, 3, 5, …”

Section: T Vaginalis Cultivationmentioning

confidence: 99%

“…Iron has been demonstrated to upregulate the expression of cysteine proteinases, which have been found to degrade the C3 portion of complement on the surface of the organism which allows the organism to evade complement-mediated damage [6]. In addition, the pathogenesis of T. vaginalis is differentially modulated by iron [7]. Considering the role of iron for the pathogenesis Trichomonas in the host, it can be assumed that this element could have a significant effect on the growth rate of the parasite.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Iron Supplementation on the Growth Rate and Antioxidant Activity of Trichomonas vaginalis

Razavi¹,

Foroudi²,

Rakhshandehroo³

et al. 2017

J Vet Sci Technol

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Trichomonas vaginalis is a common protozoan parasite found in females and males worldwide. The parasite causes mild to severe inflammations in the urogenital tract. This study was conducted to evaluate the effect of iron excess on the growth rate and the activity of antioxidant enzymes in T. vaginalis. The parasite was cultured in Diamond's Trypticase Yeast Maltose (TYM) media with and without iron supplementation and assessed at 2, 3, 5, 7, 9, 11, 13 and 15 days post inoculation (dpi). The results showed significant higher numbers of the parasite in medium with iron supplementation. Furthermore, our findings revealed higher activities of antioxidant enzymes (SOD, GPX and CAT) in parasites cultured with iron supplementation. In conclusion, the present experiment showed that iron increased not only the multiplication rate but also the antioxidant activities of T. vaginalis. It seems that iron could protect T. vaginalis from toxic oxygen metabolites during tissue invasion and helps the parasite to maintain its pathogenicity for the host.

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Acquisition of Sexually Transmitted Infections among Women Using a Variety of Contraceptive Options: A prospective Study among High‐risk African Women

et al. 2019

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Introduction In many African settings, women concurrently face substantial risk of human immunodeficiency virus type 1 ( HIV ‐1) infection, sexually transmitted infections ( STI s) and unintended pregnancies. Few studies have evaluated STI risk among users of hormonal implants and copper intrauterine devices ( IUD s) although these long‐acting reversible contraceptive methods are being promoted widely because of their benefits. Within a prospective study of women at risk for HIV ‐1, we compared the risk of acquisition of Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis among women using different contraceptive methods. Methods MTN ‐020/ ASPIRE was a randomized trial of the dapivirine vaginal ring for HIV ‐1 prevention among 2629 women aged 18 to 45 years from Malawi, South Africa, Uganda and Zimbabwe, of whom 2264 used copper IUD s or progestin‐based injectables or implants during follow‐up. Screening for the above STI s occurred semi‐annually. Results Over 3440 person‐years of follow‐up, 408 cases of C. trachomatis (incidence 11.86/100 person‐years), 196 of N. gonorrhoeae (5.70/100 person‐years) and 213 cases of T. vaginalis (6.19/100 person‐years) were detected. C. trachomatis and N. gonorrhoeae incidence were not significantly different across contraceptive methods. T. vaginalis incidence was significantly higher for copper IUD users compared to depot medroxyprogesterone acetate ( DMPA ), implant and norethisterone enanthate users. Conclusion Among African women at high HIV ‐1 risk, STI s were common. Risk of cervical infections did not differ across contraceptive methods. Significantly higher rates of T. vaginalis were observed among progestin‐based methods compared to copper IUD users. Overall, these findings call for more intensive routine screening for STI s, and they support current World Health Organization guidance that women should have a wide range of contraceptive options.

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Effect of Iron on the Virulence of Trichomonas vaginalis

Cited by 36 publications

References 0 publications

Trichomonas vaginalis perturbs the junctional complex in epithelial cells

Trichomonas vaginalis perturbs the junctional complex in epithelial cells

The Effects of Iron Supplementation on the Growth Rate and Antioxidant Activity of Trichomonas vaginalis

Acquisition of Sexually Transmitted Infections among Women Using a Variety of Contraceptive Options: A prospective Study among High‐risk African Women

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