Effect of IPTp on Plasmodium falciparum antibody levels among pregnant women and their babies in a sub-urban coastal area in Ghana

Stephens, Judith; Kyei-Baafour, Eric; Dickson, Emmanuel K.; Ofori, Jones K.; Ofori, Michael F.; Wilson, Mark L.; Quakyi, Isabella A.; Akanmori, Bartholomew D.

doi:10.1186/s12936-017-1857-1

Cited by 19 publications

(17 citation statements)

References 65 publications

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“…When mothers receive early ANC services and report for all scheduled clinics, the new target of eight ANC visits can be achieved even in low-income countries, leading to improved maternal and new born health. This is because IPTp-SP can reduce maternal malaria [ 23 ] as well as episodes of clinical malaria in the early years of life [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Intermittent preventive treatment of malaria in pregnancy: a cross-sectional survey to assess uptake of the new sulfadoxine–pyrimethamine five dose policy in Ghana

Owusu-Boateng

Anto

2017

Malar J

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BackgroundMalaria in pregnancy poses a great risk to both mother and fetus. In Ghana, malaria accounts for 3.4% of deaths and 16.8% of all hospital admissions in pregnant women. In 2014, Ghana updated her policy on intermittent preventive treatment of malaria in pregnancy with sulfadoxine–pyrimethamine (IPTp-SP) to reflect the updated policy of the WHO. This study determined the level of uptake of sulfadoxine pyrimethamine (SP) to serve as baseline for monitoring progress and also reviewed stock levels of SP, a key factor in the programme implementation.MethodsA cross-sectional hospital-based study was carried out among nursing mothers who had delivered within 12 weeks and were seeking postnatal care at Osu Government Maternity Home in Accra. Antenatal record books of the mothers were reviewed and data collected on number of visits and receipt of IPTp-SP. Mothers were interviewed and data collected on their background characteristics and obstetric history. Data on SP stock levels for the past 6 months were also reviewed. Logistic regression analysis was carried out to determine antenatal indicators on uptake of IPTp-SP using Stata version 12.ResultsThe proportion of uptake of three-five doses of SP were: IPT3 (87.5%), IPT4 (55.7%) and IPT5 (14.5%). The proportion of women who received the first dose of SP at 16 weeks of gestation was 21.3%. Women who made ≥4 visits were more likely to receive ≥3 doses of SP than those who made <4 visits (AOR = 4.57, 95% CI 1.15–18.16, p < 0.05). Women receiving the first dose of SP in the third trimester were less likely to receive ≥3 doses of SP than those who received the drug in the second trimester (AOR = 0.04, 95% CI 0.01–0.16, p < 0.05). Stock levels of SP were adequate to meet the demands by the pregnant women at the Maternity Home for the period under review.ConclusionsThe uptake of ≥3 doses of SP was high in the study area. Frequent visits to the antenatal clinic and early uptake of the first dose of SP by pregnant women are necessary to achieve the new target of five or more doses of SP.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-017-1969-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Intermittent preventive treatment of malaria in pregnancy: a cross-sectional survey to assess uptake of the new sulfadoxine–pyrimethamine five dose policy in Ghana

Owusu-Boateng

Anto

2017

Malar J

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“…Preterm delivery with associated low birth weight accounts for 28.8% of neonatal mortality in Ghana [35]. The Ghana DHS 2014 estimated neonatal mortality as 29/1000 live births [30], and the target is to reduce this to 12/1000 live births per the sustainable development goal (SDG) target 3.2 [36,37].…”

Section: Implications For Obstetric Care and Policymentioning

confidence: 99%

Coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) influences delivery outcomes among women with obstetric referrals at the district level in Ghana

Amoakoh-Coleman

Arhinful

Klipstein‐Grobusch

et al. 2020

Malar J

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Background: The aim of the study was to determine the coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) and its relationship with delivery outcomes among obstetric referral cases at the district level of healthcare. Methods: An implementation research within three districts of the Greater Accra region was conducted from May 2017 to February 2018, to assess the role of an enhanced inter-facility communication system on processes and outcomes of obstetric referrals. A cross-sectional analysis of the data on IPTp coverage as well as delivery outcomes for the period of study was conducted, for all the referrals ending up in deliveries. Primary outcomes were maternal and neonatal complications at delivery. IPTp coverage was determined as percentages and classified as adequate or inadequate. Associated factors were determined using Chi square. Odds ratios (OR, 95% CI) were estimated for predictors of adequate IPTp dose coverage for associations with delivery outcomes, with statistical significance set at p = 0.05. Results: From a total of 460 obstetric referrals from 16 lower level facilities who delivered at the three district hospitals, only 223 (48.5%) received adequate (at least 3) doses of IPTp. The district, type of facility where ANC is attended, insurance status, marital status and number of antenatal clinic visits significantly affected IPTp doses received. Adjusted ORs show that adequate IPTp coverage was significantly associated with newborn complication [0.80 (0.65-0.98); p = 0.03], low birth weight [0.51 (0.38-0.68); p < 0.01], preterm delivery [0.71 (0.55-0.90); p = 0.01] and malaria as indication for referral [0.70 (0.56-0.87); p < 0.01]. Positive association with maternal complication at delivery was seen but was not significant. Conclusion: IPTp coverage remains low in the study setting and is affected by type of health facility that ANC is received at, access to health insurance and number of times a woman attends ANC during pregnancy. This study also confirmed earlier findings that, as an intervention IPTp prevents bad outcomes of pregnancy, even among women

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“…During pregnancy, this immunity becomes suppressed. This makes both the pregnant woman and the foetus vulnerable to the adverse effects of malaria, particularly by Plasmodium falciparum [19,20].…”

Section: Discussionmentioning

confidence: 99%

Malaria prevalence in pregnant women receiving antenatal care at the health centre of University of Uyo, Nigeria

Ubulom¹,

Ettebong²,

Akpabio³

et al. 2017

APJTD

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Effect of IPTp on Plasmodium falciparum antibody levels among pregnant women and their babies in a sub-urban coastal area in Ghana

Cited by 19 publications

References 65 publications

Intermittent preventive treatment of malaria in pregnancy: a cross-sectional survey to assess uptake of the new sulfadoxine–pyrimethamine five dose policy in Ghana

Intermittent preventive treatment of malaria in pregnancy: a cross-sectional survey to assess uptake of the new sulfadoxine–pyrimethamine five dose policy in Ghana

Coverage of intermittent preventive treatment of malaria in pregnancy (IPTp) influences delivery outcomes among women with obstetric referrals at the district level in Ghana

Malaria prevalence in pregnant women receiving antenatal care at the health centre of University of Uyo, Nigeria

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