Effect of Ipsilateral and Contralateral Low-frequency Narrow-band Noise on Temporary Threshold Shift in Humans

Quaranta, A; Scaringi, Angelo; Fernandez-Vega, Susana; Quaranta, Nicola

doi:10.1080/00016480310001024

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…As our primary aim was to evaluate the effectiveness of our paradigm in inducing TTSs, which does not necessitate exposure to and potential harm to both ears, we exclusively considered monaural exposure. The choice of monaural noise/music delivery aligns with the practices of numerous previous studies ( Quaranta et al 2003 , 2004; Attias et al 2004 ; Bhagat & Davis 2008 ; Keppler et al 2010 ). The safety of our study protocol (in terms of pure-tone thresholds and DP amplitudes) is supported by the fact that, despite all participants exhibiting measurable and consistent temporary changes in their auditory function, none of them experienced nor reported any lasting hearing disorders such as PTSs.…”

Section: Discussionmentioning

confidence: 71%

Serum Prestin Level May Increase Following Music Exposure That Induces Temporary Threshold Shifts: A Pilot Study

Iliadou,

Plack,

Pastiadis

et al. 2024

Ear &Amp; Hearing

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Objectives: To determine if blood prestin level changes after exposure to music at high sound pressure levels, and if this change is associated with temporary threshold shift (TTS) and/or changes in distortion product (DP) amplitude. Design: Participants were exposed to pop-rock music at 100 dBA for 15 min monaurally through headphones. Pure-tone audiometry, DP amplitude, and blood prestin level were measured before and after exposure. Results: Fourteen adults (9 women; age range: 20 to 54 years, median age = 31 [Interquartile ratio = 6.75]) with normal hearing were included in the study. Mean prestin level increased shortly after exposure to music, then returned to baseline within 1 week, although this trend was not observed in all participants. All participants presented TTS or a decrease in DP amplitude in at least one frequency after music exposure. There was a statistically significant average threshold elevation at 4 min postexposure. Statistically significant DP amplitude shifts were observed at 4 and 6 kHz, 2 min following exposure. Mean baseline serum prestin level (mean: 140.00 pg/mL, 95% confidence interval (CI): 125.92 to 154.07) progressively increased following music exposure, reaching a maximum at 2 hr (mean: 158.29 pg/mL, 95% CI: 130.42 to 186.66) and returned to preexposure level at 1 week (mean: 139.18 pg/mL, 95% CI: 114.69 to 163.68). However, after correction for multiple comparisons, mean prestin level showed no statistically significant increase from baseline at any timepoint. No correlation between maximum blood prestin level change and average TTS or distortion product otoacoustic emission amplitude shift was found. However, in an exploratory analysis, TTS at 6 kHz (the frequency at which maximum TTS occurred) decreased significantly as baseline blood prestin level increased. Conclusions: The results suggest that blood prestin level may change after exposure to music at high sound pressure levels, although statistical significance was not reached in this relatively small sample after correction. Baseline serum prestin level may also predict the degree of TTS. These findings thus suggest that the role of baseline serum prestin level as a proxy marker of cochlear susceptibility to intense music exposure should be further explored.

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Section: Discussionmentioning

confidence: 71%

Serum Prestin Level May Increase Following Music Exposure That Induces Temporary Threshold Shifts: A Pilot Study

Iliadou,

Plack,

Pastiadis

et al. 2024

Ear &Amp; Hearing

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“…Moreover, the combination of hair cell damage and apoptosis leads to hearing loss. 21 Antioxidants, such as vitamin B12, folic acid and N-acetylcysteine can have a positive impact on patients with noise overexposure and reflect a promising new treatment strategy for preventing the effects of noise on hearing. 19 This study is the first comprehensive analysis of associations between genetic polymorphisms in CDH23 genes and NIHL.…”

Section: Discussionmentioning

confidence: 99%

Variations in the Cadherin 23 Gene Associated With Noise-Induced Hearing Loss

Jiao,

Yu,

et al. 2024

JMDH

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Background The relationship between CDH23 gene variants and NIHL is unclear. This study investigates the association between cadherin 23 ( CDH23 ) gene variants and noise-induced hearing loss (NIHL). Methods This is a case-control study. Workers who were exposed to noise from a steel factory in North China were recruited and divided into two groups: the case group (both ears’ high-frequency threshold average [BHFTA] ≥40dB) and the control group (BHFTA ≤25 dB). This study used the generalised multifactor dimensionality reduction method to analyse the association among 18 single-nucleotide polymorphisms (SNPs) in CDH23 and NIHL. Logistic regression was performed to investigate the main effects of SNPs and the interactions between cumulative noise exposure (CNE) and SNPs. Furthermore, CNE was adjusted for age, gender, smoking, drinking, physical exercise and hypertension. Results This study recruited 1,117 participants. The results showed that for rs11592462, participants who carried the GG genotype showed an association with NIHL greater than that of those who carried the CC genotype. Accordingly, genetic variation in the CDH23 gene could play an essential role in determining individual susceptibility to NIHL. Conclusion Genetic variations in the CDH23 gene may play an important role in determining individual susceptibility to NIHL. These results provide new insight into the pathogenesis and early prevention of NIHL.

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“…In animal models, the antioxidant property of ALA results in a protective effect for the cochlea against prolonged noise exposure [ 43 , 44 ] and age-related and cisplatin-induced hearing loss [ 45 , 46 ]. Moreover, ALA acts as an anti-inflammatory agent by up-regulating the expression of nerve growth factor in experimental diabetic neuropathy [ 47 ] and counteracting the cumulative damage to Schwann cells induced by endoneurial hypoxia [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores

et al. 2023

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Background and Objectives: Tinnitus affects millions of adults. Many therapies, including complementary and alternative medicine and tinnitus retraining therapies, have been trialed, but an effective option, particularly for chronic subjective tinnitus (CTS), is still lacking. Materials and Methods: This study investigated the effects of alpha-lipoic acid (600 mg. per day for two months) on two groups of patients using a questionnaire. One group (A) was affected by tinnitus associated with likely cochlear dysfunction and metabolic syndrome, and the other (B) was composed of subjects with acoustic nerve lesions. All the patients were asked to complete the Italian version of the tinnitus handicap inventory (THI) to determine the overall degree of perceived annoyance at the beginning and end of therapy. Pure tone averages for speech frequencies and for high frequencies were computed, and psychoacoustic pitch and loudness matches were determined for each subject before and after treatment. Results: The pure tone audiometry, pitch, loudness, and THI scores of both groups were reported. In group A, statistically significant differences were observed for the “functional” and “emotional” subscales. The total score of THI and the loudness of tinnitus were also significantly reduced. No statistically significant differences were observed in group B. Conclusions: These findings suggest a possible contribution of the antioxidant effect to the organ of Corti in subjects with metabolic syndrome and CST.

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Effect of Ipsilateral and Contralateral Low-frequency Narrow-band Noise on Temporary Threshold Shift in Humans

Abstract: The results of this study show that an ipsilateral low-intensity, low-frequency (250 Hz) NBN can give protection from a TTS induced by a 2 kHz tone. Contralateral low-frequency NBN did not induce any protective effect.

Cited by 8 publications

References 11 publications

Serum Prestin Level May Increase Following Music Exposure That Induces Temporary Threshold Shifts: A Pilot Study

Serum Prestin Level May Increase Following Music Exposure That Induces Temporary Threshold Shifts: A Pilot Study

Variations in the Cadherin 23 Gene Associated With Noise-Induced Hearing Loss

The Effect of Alpha-Lipoic Acid in the Treatment of Chronic Subjective Tinnitus through the Tinnitus Handicap Inventory Scores

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