Effect of Ipratropium Bromide Treatment on Oxygen Saturation and Sleep Quality in COPD

Martin, Richard J.; Bartelson, Becki L. Bucher; Smith, Philip L.; Hudgel, David W.; Lewis, David A.; Pohl, Gerhardt; Koker, Paul; Souhrada, J. F.

doi:10.1378/chest.115.5.1338

Cited by 97 publications

(57 citation statements)

References 25 publications

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“…Previous studies showed equivocal benefits of theophylline, inhaled bronchodilators, and supplemental oxygen on sleep quality. [10][11][12][13][14][15] Management should therefore not just concentrate on drug control of airway obstruction.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Rehabilitation Improves Subjective Sleep Quality in COPD

et al. 2014

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After PR, the PSQI score decreased from 9.41 ؎ 4.33 to 7.82 ؎ 3.90 (P < .001). The number of subjects with a PSQI score > 5 also decreased (85.3-64.7%, P ‫؍‬ .006). There were significant improvements in HRQOL (SGRQ, P ‫؍‬ .003), exercise capacity (peak oxygen uptake, P < .001; and work rate, P < .001), dyspnea score (P < .001), and respiratory muscle strength (inspiratory muscle strength, P ‫؍‬ .005; and expiratory muscle strength, P ‫؍‬ .004) after PR. There were no significant changes in pulmonary function test results (FEV 1 , P ‫؍‬ .77; FVC, P ‫؍‬ .90; FEV 1 /FVC, P ‫؍‬ .90). CONCLUSIONS: PR results in significant improvement in sleep quality, along with concurrent improvements in HRQOL and exercise capacity. PR is an effective nonpharmacologic treatment to improve sleep quality in patients with COPD and should be part of their clinical management.

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Section: Introductionmentioning

confidence: 99%

Pulmonary Rehabilitation Improves Subjective Sleep Quality in COPD

et al. 2014

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“…Theophylline [65] and anticholinergic medicines may ameliorate nocturnal desaturation and ipratropium increases sleep quality [66]. Ipratropium bromide enhances sleep quality, abrogates nocturnal oxygen desaturation, improves perceived sleep quality, and increases REM sleep duration without any effects on other sleep phases or total sleep duration [66].…”

Section: Patient B "Sometimes I Have a Stuffed Throat And Become Shomentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease and Sleep Quality

Tel Aydin

2014

COPD Clinical Perspectives

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“…In moderate to severe COPD, ipratropium inhaled 4 times a day improved nocturnal oxygen saturation, and subjective sleep quality was better as well. 128 Tiotropium and longacting ␤ agonists also improve nocturnal oxygen saturation. 129,130 Oral steroid therapy in stable COPD has been shown to improve NOD and, surprisingly, increase total sleep time.…”

Section: Treatment Of the Underlying Pulmonary Diseasementioning

confidence: 99%

Supplemental Oxygen Needs During Sleep. Who Benefits?

Owens

2012

Respir Care

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Effect of Ipratropium Bromide Treatment on Oxygen Saturation and Sleep Quality in COPD

Cited by 97 publications

References 25 publications

Pulmonary Rehabilitation Improves Subjective Sleep Quality in COPD

Pulmonary Rehabilitation Improves Subjective Sleep Quality in COPD

Chronic Obstructive Pulmonary Disease and Sleep Quality

Supplemental Oxygen Needs During Sleep. Who Benefits?

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