Effect of ions concentration in buffer solutions on the nucleation of hydroxyapatite surface on the octacalcium phosphate granules

Abstract

Octacalcium phosphate granules were subsequently immersed for different lengths of time from 1 day to 44 days at constant temperature 37±0.4°C in solutions, simulating the extracellular body fluids: Supersaturated Calcification Solution (SCS), Simulated Body Fluid (SBF), based on the ISO-10993 “Biological Evaluation of Medical Devices” standard. The role of buffer`s systems pH-value, time of the material exposure and calcium and phosphorus ionic concentrations were analysed with the main focus on kinetics of degradation, changes in the morphological characteristics and phase composition of octacalcium phosphate samples.