Effect of Iomeprol on Renal Function Immediately after Abdominal Angiography

Murakami, Ryusuke; Tajima, H.; Kumazaki, T.

doi:10.3109/02841859609175477

Cited by 13 publications

(12 citation statements)

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“…The renal clearance during haemodialysis must therefore significantly contribute to the entire elimination. This correlates to the renal clearance data found in patients without renal impairment [10]. The application of iomeprol resulted in an osmotic diure- Matzkies/Reinecke/Tombach/Kosch/ Hegger/Milius/Hohage/Kisters/Kerber/ Schaefer sis and acute tubular toxicity directly after application until 120 min after application.…”

Section: Discussionsupporting

confidence: 61%

Influence of Dialysis Procedure, Membrane Surface and Membrane Material on Iopromide Elimination in Patients with Reduced Kidney Function

Matzkies¹,

Reinecke²,

Tombach

et al. 2000

Am J Nephrol

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Haemodialysis for the elimination of contrast medium in patients with advanced renal failure is a common procedure. Even though sufficient elimination with the use of regular low-flux membranes is documented, large differences in results have been reported in prior investigations. We, therefore, compared Cuprophan and polysulfone dialysers with different surface areas to haemofiltration with different amounts of substitution fluid in 40 patients with compromised renal function after coronary angiography. Plasma iodine concentrations were measured by fluorescent excitation analysis. At constant blood flow rates of 200 ml/min, Cuprophan membranes with 1.3 m² surface area had a clearance rate of 87 ml/min, whereas polysulfone membranes of comparable size displayed a significantly higher clearance rate of 147 ml/min. Polysulfone membranes with 1.8 m² surface area showed a small but insignificant increase in the iodine clearance (162 ml/min), while Cuprophan membranes displayed an increase in clearance rates (121 ml/min). Additional ultrafiltration led to a further increase in the plasma clearance of both membranes and reduced urinary iodine excretion. Haemofiltration was comparable to haemodialysis in terms of efficacy and thus represents an alternative method. Clearance of iopromide during haemodialysis with polysulfone membranes is higher than with Cuprophan membranes. Elimination rates can be further increased by additional ultrafiltration. Haemofiltration is comparable to haemodialysis regarding contrast medium elimination.

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Section: Discussionsupporting

confidence: 61%

Influence of Dialysis Procedure, Membrane Surface and Membrane Material on Iopromide Elimination in Patients with Reduced Kidney Function

Matzkies¹,

Reinecke²,

Tombach

et al. 2000

Am J Nephrol

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“…No entanto, considerando a análise gráfica dos grupos (Figura 1), sugere-se que exista essa interação, pois se observou uma sinalização de que o GIH apresentou maior oscilação do volume, com aumento significante após 1 hora e 30 minutos da administração do contraste, e com diminuição significante em 48 horas, enquanto o GID, o apresentou mais constante ao longo do tempo. Considerando que o volume renal pode ser mais expressivo ao avaliar a expansão medular, por utilizar três dimensões lineares, poder-se-ia sugerir que o MCI de baixa osmolaridade promoveu maior diurese em relação ao isosmolar, como foi comprovado por Murakami et al (1998) por meio da análise do volume urinário do paciente humano. Este fato sustenta a hipótese levantada em alguns estudos médicos de que o MCI de baixa osmolalidade seria mais nocivo em pacientes de risco para o desenvolvimento da NIC (Aspelin et al 2003, Jo et al 2006, Bartorelli & Marenzi 2008, pois a maior diurese, maior fluxo e aumento da pressão intratubular intensificariam a vasoconstrição intrarrenal e resultariam em hipóxia e isquemia medular renal com consequências relevantes (Bartorelli & Marenzi 2008).…”

Section: Discussionunclassified

Ultrassonografia modo B e Doppler na avaliação renal de cães submetidos à tomografia computadorizada após administração intravenosa de diferentes meios de contraste iodado

et al. 2017

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Contrast-induced nephropathy (CIN) is an acute disease, secondary to intravascular administration of iodinated contrast media (ICM). The most important mechanisms of this nephropathy are intrarenal prolonged vasoconstriction, medular hypoxia, and ischemia associated with renal tubular damage due to contrast cytotoxicity. Owing to the limited information available in veterinary literature regarding these mechanisms this study aims to compare the renal effects of intravenous administration of two nonionic ICM of different osmolarities in groups of dogs with risk factors for CIN development, by using a B-mode, color, power-and pulsed-wave Doppler ultrasonography, and other laboratory tests, in order to indirectly estimate the nephrotoxic potential of each contrast. The following two groups were established according to the nonionic ICM used: the GIH group [11 dogs administered iohexol (low osmolarity)] and the GID group [seven dogs administered iodixanol (iso-osmolarity)]. Both the groups were administered the same dose (600mgI/kg/IV). The following renal aspects were evaluated before administration of ICM (baseline) and after 1h30min, 24h, and 48h: renal morphometry (length and volume), renal morphology, cortical echogenicity, renal perfusion, and intrarenal vascular resistance (resistive and pulsatility indices); in addition, urinalysis was performed, and urinary gamma-glutamyl transferase:creatinine ratio (GGT:C), urinary protein:creatinine ratio (UPC), and serum creatinine were also measured. Both groups showed similar characteristics with respect to the length, volume, UPC ratio, urinalysis, and serum creatinine levels. No similarity was observed with respect to the pulsatility index (PI) in both the groups and there were no significant differences between baseline and 1h30min, 24h and 48h time points. With respect to the IR and urinary GGT:C, both groups showed no similarity, and significant increases were 1 Recebido em 13 de maio de 2016.Aceito para publicação em 6 de dezembro de 2016. Parte da tese de doutorado do primeiro autor.

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“…In addition, according to the past reports that indicate there was no significant difference in the contrast effect except in the kidney between monomeric and dimeric contrast media [2,[9][10][11], and the reports of increasing urinary volume with the use of monomeric contrast media relative to dimeric contrast media [7,10], it is considered that the remarkable difference in the contrast effect in the kidney is mainly derived from the osmotic diuresis in the renal tubules. This means that, after passing the glomerulus, the monomeric contrast media, with high osmolarity, is diluted in the renal tubules because it receives greater influence of osmotic diuresis than dimeric contrast media by reason of its high osmolarity [6]. Provided that the iodine concentration is the same, the monomeric contrast media have approximately a half of the molecular weight and twice the molar concentration of dimeric contrast Fig.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Excretory Urographic Contrast Effects of Dimeric and Monomeric Non-Ionic Iodinated Contrast Media in Dogs

Kishimoto

Yamada

Watanabe

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. In excretory urography, the osmolarity of contrast media has rarely been treated as important in veterinary medicine. In this study, the contrast effect of two contrast media (monomeric iohexol and dimeric iodixanol) in the renal cortex and aorta were compared using computed tomography (CT). Five beagle dogs were used and the study employed a cross-over method for each contrast media. The results showed that there was no difference between the media in the aorta, but iodixanol showed higher CT value and a longer contrast effect than iohexol in the renal cortex, in spite of having the same iodine dosage. It is believed that iodixanol, with its low osmolarity, is diluted less by osmotic diuresis than monomeric iohexol. It is important to consider the osmolarity of the contrast media when evaluating the contrast effect, and it is essential to use the same contrast media for each examination, or the renal excretory speed will be under/overestimated.

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Effect of Iomeprol on Renal Function Immediately after Abdominal Angiography

Abstract: diaslcnomsris mixlure of N. N-bin(2.3-dihydroxypropyl)-5-[(hydroxyacstyl) methylamino ]-2.4.6-tniodo-I ..l-knzsne. dicarboxamide on .

Cited by 13 publications

References 0 publications

Influence of Dialysis Procedure, Membrane Surface and Membrane Material on Iopromide Elimination in Patients with Reduced Kidney Function

Influence of Dialysis Procedure, Membrane Surface and Membrane Material on Iopromide Elimination in Patients with Reduced Kidney Function

Ultrassonografia modo B e Doppler na avaliação renal de cães submetidos à tomografia computadorizada após administração intravenosa de diferentes meios de contraste iodado

Comparison of Excretory Urographic Contrast Effects of Dimeric and Monomeric Non-Ionic Iodinated Contrast Media in Dogs

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