Effect of Iodinated Contrast Media on Blood Clotting

Corot, Claire; Jm, Perrin; Belleville, J; Amiel, M; Eloy, R.

doi:10.1097/00004424-198905000-00010

Cited by 50 publications

(8 citation statements)

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“…Risk factors for unexpected clot formation are not known with certainty. This could be multifactorial, with some studies suggesting that iodinated contrast medium used during angiography may react with vascular endothelium to promote clot formation 6. However if this were the case, we would expect to see this complication more often.…”

Section: Discussionmentioning

confidence: 99%

Rupture of aneurysms in the immediate post-coiling period

Dmytriw

Pickett

Shankar

2013

J NeuroIntervent Surg

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Section: Discussionmentioning

confidence: 99%

Rupture of aneurysms in the immediate post-coiling period

Dmytriw

Pickett

Shankar

2013

J NeuroIntervent Surg

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“…Hyperosmolar ionic CM have an osmolality six to seven times greater than that of serum and the osmolality of low osmolar non‐ionic CM is twice that of serum. This osmotic effect is rapidly compensated by a shift of extracellular fluid to the vascular compartment (haemodilution) after CM injection (Corot et al., 1989; Gardinali et al., 1997).…”

Section: Discussionmentioning

confidence: 99%

Effects of Hyperosmolar Ionic and Low Osmolar Non‐ionic Contrast Media on Coagulation Times and Some Blood Parameters in Dogs: an In Vivo Study

Izci¹,

Oğurtan²,

Ceylan³

2003

Journal of Veterinary Medicine Series A

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The purpose of this study is to evaluate the effects of hyperosmolar ionic contrast media (CM) (diatrizoate) and low osmolar non-ionic CM (iohexol and ioxilan) on coagulation time and some blood parameters in dogs in vivo. The animals were divided into three groups in equal numbers. The dogs in groups I, II and III received diatrizoate, iohexol and ioxilan at the dose of 700 mgI/kg intravenously (IV) as a bolus, respectively. Administration of contrast media and blood samples were collected from vena cephalica antebrachii prior to CM administration and thereafter at 3, 15, 30, 60, 90 and 180 min and 24 h to measure the coagulation factors [activated partial thromboplastin time (APTT), prothorombin time (PT), fibrinogen and fibrinogen degradation products] and some other blood parameters [red blood cells, platelet, white blood cells, haematocrit (Ht) and haemoglobin (Hb)]. While a statistically significant decrease was observed on APTT at 15 min in group III, no significant differences were found in groups I and II. All the groups had insignificant alterations for PT, fibrinogen and fibrinogen degradation product, following CM administration. Significant decreases were observed for platelet at 3 min in all groups. This decrease was also significant at 15- and 30- min intervals in group I. There were significant decreases for erythrocytes, Ht and Hb measurements within 30 min, and no significant alterations were observed for leucocytes within 60 min in all groups compared with baseline values. No differences were observed with regard to coagulation times and some blood parameters as far as long-lasting and major effects of each CM are concerned.

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“…It seems to be settled (5,13,15) that both ionic and nonionic contrast agents delay the physiologic coagulation process, also in catheters and syringes, and that the ionic contrast agents are stronger anticoagulants than the nonionic ones. On the other hand, the contact between blood and the surfaces of catheters and syringes is definitely an activating factor for the coagulation mechanism.…”

Section: Discussionmentioning

confidence: 99%