Effect of Intravitreal Triamcinolone (IVT) Injection on Visual Acuity in Patients with Ischemic CRVO

Abstract

Aim: To govern the intravitreal injection effect of triamcinolone (IVT) on visual acuity in patients with ischemic central retinal vein obstruction (CRVO). Study Design: A randomized clinical trial. Methods:The patients with ischemic event of CRVO less than amonth who were referred to the ophthalmology departmentof Hayatabad Medical Complex, Peshawar and Woman Medical and Dental College, Abbottabad. Patents were included for the duration from March 2021 to August 2021.Inclusion criteria were: < one month duration of CRVO, normal intraocular pressure, no symptoms of hypertensive or diabetic retinopathy, history of eye surgery or laser therapy, and no vascular disease. Patients were randomized into 2 groups: control group (no injection) and intervention group (0.1 cc IVT injection). Follow-up is scheduled for 1, 2, 3 and 6 months after injection for all patients. The main outcomes of the study were evaluated and used for statistical analysis were SPSS software version 21.0 ion test-t statistical test. Results:70 patients (36 men and 34 women) participated in the study. 62.1 ± 8.9 was the mean age of patients (range: 30-80). The time of symptoms was 20 ± 4.9 days in the control group and in the IVT group; duration was 19 ± 6 days (p = 0.65). All subjects had symptoms of ischemic CRVO. The IVT group has mean baseline visual acuity of 1.80 ± 0.19 logMAR and in the control group; it was 1.91 ± 0.08 logMAR (p = 0.1). The enhancement in VA in the IVT group was better after one month as compared to the control group (p = 0.018); though, this variance was not significant in other control studies. Also, before and after injection; the alteration in IOP was not significant (p = 0.802). Conclusions: This analysisexhibited that triamcinolone intravitreal injection had no substantial long-term outcome on visual acuity among CRVO patients. Keywords:Triamcinolone, Central Retinal Vein Occlusion