Effect of intravenous prostaglandin E<sub>1</sub> on pial vessel diameters and intracranial pressure in rabbits

Miyabe, Masayuki; Fukuda, Tomoyuki; Saito, Shigeru; Tajima, K; H, Toyooka

doi:10.1034/j.1399-6576.2001.451016.x

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Both hypotensive groups had significantly lower MAP from the normotensive group but were not significantly different from each other, potentially due to the heterogeneous response of individual animals to the two dosages of PGE 1 . PGE 1 was chosen to manipulate MAP because at dosages of 3.0 μg kg −1 min −1 , the agent has no effect on cerebrovascular tone and does not impair the CVR in rabbits (Miyabe et al 2001, Takenaka et al 2003 and in humans (Abe 1993, Abe andYoshiya 1993). Interestingly, we found that ICP did not change over the range of MAP tested, which facilitated the use of MAP as a direct correlate of CPP and allowed us to minimize the invasiveness of surgery in the majority of the experiments.…”

Section: Discussionmentioning

confidence: 89%

Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension

et al. 2011

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Early diagnosis of cerebrovascular disease requires the accurate identification of brain regions with compromised cerebral perfusion pressure (CPP). Current clinical measures of CPP are invasive and lack regional information. Dynamic contrast-enhanced imaging provides a means of looking at regional cerebral hemodynamics. The purpose of this study was to determine if any of the parameters associated with dynamic contrast-enhanced imaging could be used as an index for CPP under graded systemic hypotension in a rabbit model. Cerebral blood flow (CBF), cerebral blood volume, mean transit time (MTT), and cerebrovascular reserve (CVR) were measured using Computed Tomography Perfusion in three groups: normotensive (n = 14), mild hypotensive (n = 9), and moderate hypotensive (n = 6). MTT demonstrated the strongest correlation with CPP (ρ = -0.642, P < 0.05). CBF was the only other parameter to demonstrate a statistically significant correlation (ρ = 0.575, P < 0.05). CVR is gaining momentum for diagnosing cerebrovascular disease; however, the technique requires patients to be given a hemodynamic challenge, which could aggravate symptoms and even trigger stroke. The results of this study suggest that the use of MTT, not requiring hemodynamic manipulation, is more sensitive to subtle changes in CPP, as would occur in the early stages of cerebrovascular disease.

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Section: Discussionmentioning

confidence: 89%

Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension

et al. 2011

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“…It has been proposed that PGE1 may improve symptoms in patients with lumbar spinal canal stenosis by promoting blood flow in the cauda equina and nerve roots through its vasodilating and anti-platelet aggregating effects (Yoshihara, 2016). In addition, Miyabe et al (2001) showed that cerebral microvessel diameter in rabbits is increased by intravenous administration of PGE1. As our previous finding has shown that the VAs have the ability to increase their diameter as an adaptive response to BCCAO (Jing et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin E1 Alleviates Cognitive Dysfunction in Chronic Cerebral Hypoperfusion Rats by Improving Hemodynamics

Xie

Chen

et al. 2019

Front. Neurosci.

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Compensatory vascular mechanisms can restore cerebral blood flow (CBF) but fail to protect against chronic cerebral hypoperfusion (CCH)-mediated neuronal damage and cognitive impairment. Prostaglandin E1 (PGE1) is known as a vasodilator to protect against ischemic injury in animal models, but its protective role in CCH remains unclear. To determine the effect of PGE1 on cerebral hemodynamics and cognitive functions in CCH, bilateral common carotid artery occlusion (BCCAO) was used to mimic CCH in rats, which were subsequently intravenously injected with PGE1 daily for 2 weeks. Magnetic resonance imaging, immunofluorescence staining and Morris water maze (MWM) were used to evaluate CBF, angiogenesis, and cognitive functions, respectively. We found that PGE1 treatment significantly restored CBF by enhancing vertebral artery dilation. In addition, PGE1 treatment increased the number of microvascular endothelial cells and neuronal cells in the hippocampus, and decreased the numbers of astrocyte and apoptotic cells. In the MWM test, we further showed that the escape latency of CCH rats was significantly reduced after PGE1 treatment. Our results suggest that PGE1 ameliorates cognitive dysfunction in CCH rats by enhancing CBF recovery, sustaining angiogenesis, and reducing astrocyte activation and neuronal loss.

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“…9 The scalp was incised and retracted, and the temporal muscle was removed. A hole approximately 8 mm in diameter was made in the parietal bone.…”

Section: Ma At Te Er Ri Ia Al Ls S a An Nd D M Me Et Th Ho Od Ds S mentioning

confidence: 99%

Olprinone, a phosphodiesterase III inhibitor, does not affect hypoxia-induced pial arteriolar dilatation in rabbits

Miyabe

Tajima

Takahashi

et al. 2003

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : Olprinone, a phosphodiesterase III inhibitor, is used for the treatment of heart failure or asthma. Such patients may suffer from hypoxia. However, the effect of olprinone on the cerebral vasodilator response to hypoxia remains unclear.M Me et th ho od ds s: : Rabbits were anesthetized and ventilated mechanically. The pial arteriolar diameter was determined using a cranial window and intravital microscopy. Hypoxia was induced twice in the same animal by reducing FIO 2 to 0.1. The first episode was induced during an infusion of saline, and the second during an infusion of saline (saline group; n = 8) or olprinone (1 µg·kg , OLP10 group; n = 8). The pial arteriolar responses to hypoxia were recorded and compared between the two episodes of hypoxia in each group. R Re es su ul lt ts s: : Blood gas data in the first hypoxic challenge were identical to those in the second challenge in each group. Pial arteriolar diameter increased significantly during hypoxia. In arterioles between 50-100 µm diameter, first and second hypoxia-induced pial arteriolar dilatation in OLP1 were 13 ± 6% and 10 ± 7% respectively (P = 0.574 ) and those in OLP10 were 16 ± 6% and 15 ± 7% respectively (P = 0.606). In arterioles between 25-50 µm, the results were the same as in arterioles between 50-100 µm.C Co on nc cl lu us si io on n: : Olprinone does not affect the hypoxia-induced dilatation of pial arterioles in pentobarbital anesthetized rabbits. OLP1, de 13 ± 6 % et de 10 ± 7 % respectivement (P = 0,574 ) et dans le groupe OLP10, de 16 ± 6 % et de 15 ± 7 % respectivement ( P = 0,606 Objectif

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Effect of intravenous prostaglandin E₁ on pial vessel diameters and intracranial pressure in rabbits

Abstract: We conclude that PGE1 might be a suitable drug for induced hypotension in neurosurgery from the viewpoint of its small effect on the cerebral microvessels and ICP.

Cited by 8 publications

References 18 publications

Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension

Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension

Prostaglandin E1 Alleviates Cognitive Dysfunction in Chronic Cerebral Hypoperfusion Rats by Improving Hemodynamics

Olprinone, a phosphodiesterase III inhibitor, does not affect hypoxia-induced pial arteriolar dilatation in rabbits

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Effect of intravenous prostaglandin E1 on pial vessel diameters and intracranial pressure in rabbits

Abstract: We conclude that PGE1 might be a suitable drug for induced hypotension in neurosurgery from the viewpoint of its small effect on the cerebral microvessels and ICP.

Cited by 8 publications

References 18 publications

Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension

Mean transit time as an index of cerebral perfusion pressure in experimental systemic hypotension

Prostaglandin E1 Alleviates Cognitive Dysfunction in Chronic Cerebral Hypoperfusion Rats by Improving Hemodynamics

Olprinone, a phosphodiesterase III inhibitor, does not affect hypoxia-induced pial arteriolar dilatation in rabbits

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Effect of intravenous prostaglandin E₁ on pial vessel diameters and intracranial pressure in rabbits