Effect of intravenous lignocaine on perioperative stress response and post‐surgical ileus in elective open abdominal surgeries: a double‐blind randomized controlled trial

Sridhar, P; Sistla, Sarath Chandra; Ali, Sheik Manwar; Karthikeyan, Vilvapathy Senguttuvan; Badhe, Ashok Shankar; Ananthanarayanan, Palghat Hariharan

doi:10.1111/ans.12783

Cited by 36 publications

(30 citation statements)

References 18 publications

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“… 56 In one study analyzing the effect of intravenous lignocaine given intraoperatively, they reported a reduction in postoperative analgesic requirements as well as improved time to flatus and reduced postoperative nausea and vomiting. 28 As previously stated, there is little reported evidence on the effects of different analgesic methods on the systemic inflammatory response following colorectal surgery. One study reported that those receiving intravenous lignocaine had lower postoperative levels of both CRP and IL-6 following major abdominal surgery.…”

Section: Resultsmentioning

confidence: 99%

“…Table 2 summarizes the included studies for each ERAS component and the marker of the SIR analyzed. 10 – 28 Evidence relating to other outcomes of ERAS programmes such as length of stay or postoperative complications were obtained from the most recent Cochrane Reviews or meta-analyses on the specific topic. Meta-analysis of included studies was not performed because of significant heterogeneity among study methodology, populations, and outcomes measured.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced Recovery After Surgery

Watt

McSorley²,

Horgan³

et al. 2015

Medicine

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Enhanced Recovery or Fast Track Recovery after Surgery protocols (ERAS) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery.The present systematic review aimed to examine the impact on the magnitude of the systemic inflammatory response (SIR) for each ERAS component following colorectal surgery using objective markers such as C-reactive protein (CRP) and interleukin-6 (IL-6).A literature search was performed of the US National Library of Medicine (MEDLINE), EMBASE, PubMed, and the Cochrane Database of Systematic Reviews using appropriate keywords and subject headings to February 2015.Included studies had to assess the impact of the selected ERAS component on the SIR using either CRP or IL-6.Nineteen studies, including 1898 patients, were included. Fourteen studies (1246 patients) examined the impact of laparoscopic surgery on the postoperative markers of SIR. Ten of these studies (1040 patients) reported that laparoscopic surgery reduced postoperative CRP. One study (53 patients) reported reduced postoperative CRP using opioid-minimising analgesia. One study (142 patients) reported no change in postoperative CRP following preoperative carbohydrate loading. Two studies (108 patients) reported conflicting results with respect to the impact of goal-directed fluid therapy on postoperative IL-6. No studies examined the effect of other ERAS components, including mechanical bowel preparation, antibiotic prophylaxis, thromboprophylaxis, and avoidance of nasogastric tubes and peritoneal drains on markers of the postoperative SIR following colorectal surgery.The present systematic review shows that, with the exception of laparoscopic surgery, objective evidence of the effect of individual components of ERAS protocols in reducing the stress response following colorectal surgery is limited.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Enhanced Recovery After Surgery

Watt

McSorley²,

Horgan³

et al. 2015

Medicine

View full text Add to dashboard Cite

show abstract

“…Table 2 summarizes the included studies for each ERAS component and the marker of the SIR analyzed. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Evidence relating to other outcomes of ERAS programmes such as length of stay or postoperative complications were obtained from the most recent Cochrane Reviews or meta-analyses on the specific topic. Metaanalysis of included studies was not performed because of significant heterogeneity among study methodology, populations, and outcomes measured.…”

Section: Methodsmentioning

confidence: 99%

Enhanced Recovery After Surgery

Dejong¹,

Meyenfeldt²

2019

Frontiers Research Topics

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Enhanced Recovery or Fast Track Recovery after Surgery protocols (ERAS) have significantly changed perioperative care following colorectal surgery and are promoted as reducing the stress response to surgery. The present systematic review aimed to examine the impact on the magnitude of the systemic inflammatory response (SIR) for each ERAS component following colorectal surgery using objective markers such as C-reactive protein (CRP) and interleukin-6 (IL-6). A literature search was performed of the US National Library of Medicine (MEDLINE), EMBASE, PubMed, and the Cochrane Database of Systematic Reviews using appropriate keywords and subject headings to February 2015. Included studies had to assess the impact of the selected ERAS component on the SIR using either CRP or IL-6. Nineteen studies, including 1898 patients, were included. Fourteen studies (1246 patients) examined the impact of laparoscopic surgery on the postoperative markers of SIR. Ten of these studies (1040 patients) reported that laparoscopic surgery reduced postoperative CRP. One study (53 patients) reported reduced postoperative CRP using opioidminimising analgesia. One study (142 patients) reported no change in postoperative CRP following preoperative carbohydrate loading. Two studies (108 patients) reported conflicting results with respect to the impact of goal-directed fluid therapy on postoperative IL-6. No studies examined the effect of other ERAS components, including mechanical bowel preparation, antibiotic prophylaxis, thromboprophylaxis, and avoidance of nasogastric tubes and peritoneal drains on markers of the postoperative SIR following colorectal surgery. The present systematic review shows that, with the exception of laparoscopic surgery, objective evidence of the effect of individual components of ERAS protocols in reducing the stress response following colorectal surgery is limited.

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“…It has several beneficial effects apart from reducing opioid requirements (by up to two-thirds): there is a reduced duration of PONV, ileus, and hospital stay. 41,42 In addition, there are other systemic effects, such as reduced stress response as measured by total leukocyte count, C-reactive protein, and interleukin-6 (IL-6), 43 and possibly an anticancer effect too. 44 Many of these effects seem to be more marked for open surgery.…”

Section: Intravenous Lidocainementioning

confidence: 99%