Effect of intravenous lidocaine on cough response to endotracheal intubation in propofol-anaesthetized dogs

Panti, Ambra; Cafrita, Ioana C; Clark, Louise

doi:10.1111/vaa.12332

Cited by 21 publications

(13 citation statements)

References 34 publications

(72 reference statements)

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“…Despite the observed variability, the loss of PWR was expected based on the previously reported properties of lidocaine. Specifically, intravenous lidocaine has been noted to decrease laryngeal reflexes at intubation in dogs [ 41 , 42 ], and children [ 43 ]. In addition, lidocaine continuous-rate infusion confers an anesthetic-sparing effect in mice [ 13 ], and allows for dose reduction of inhalants and opioids through perioperative analgesic effects [ 11 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Anesthetic effects and body weight changes associated with ketamine-xylazine-lidocaine administered to CD-1 mice

et al. 2017

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Anesthesia for mice is commonly performed through the injection of parenteral agents via the intraperitoneal (IP) route. Variability in anesthetic sensitivities has been noted in mice resulting in inconsistencies in anesthetic depth and/or mortality. Anesthetic protocols that improve consistency and safety are needed. The objectives of this study were to assess the effects of intraperitoneal (IP) ketamine (95 mg/kg) and xylazine (7 mg/kg) alone or combined with lidocaine at 4, 8, or 16 mg/kg on time to loss (LRR) and return (RRR) of righting reflex, duration of immobilization and loss of pedal withdrawal response (PWR), body weight and histopathology in CD-1 mice. In a prospective, randomized trial, 36 male CD-1 mice, 4–6 weeks of age were randomly assigned to 5 groups: saline (SA, n = 4); ketamine-xylazine (KX, n = 8); ketamine-xylazine-lidocaine 4 mg/kg (KXL4, n = 8); ketamine-xylazine-lidocaine 8 mg/kg (KXL8, n = 8); ketamine-xylazine-lidocaine 16 mg/kg (KXL16, n = 8). Two mice in each group were euthanized at day 2 post-injection and the remaining mice were euthanized at day 11 post-injection. After IP injection, LRR and RRR, duration of immobilization and loss of PWR, body weight and histopathology were evaluated. LRR occurred sooner in mice receiving KXL16 compared with KX, with median (range) times of 78 (62–104) and 107 (91–298) seconds, respectively. Loss of PWR occurred in 1, 5, 4, 6 mice for groups KX, KXL4, KXL8, and KXL16 respectively. Median (range) duration of absent PWR was longer in mice receiving KXL16 at 13 (0–30) minutes, compared to KX at 0 (0–9) minutes. Duration of immobilization and RRR were not different between groups. Weight loss occurred 2 days following anesthesia but was not different between groups. Weight gain was significantly greater in all lidocaine groups 11 days post-injection compared to KX. No mortality or histopathologic abnormalities were observed in any group. Lidocaine administered with ketamine and xylazine shortens the onset of anesthesia in mice and improves anesthetic depth without prolonging recovery time.

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Section: Discussionmentioning

confidence: 99%

Anesthetic effects and body weight changes associated with ketamine-xylazine-lidocaine administered to CD-1 mice

et al. 2017

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“…We speculated that target-controlled plasma infusion of lidocaine at 3 mg/L could inhibit the laryngoscopy-mediated inflammatory response; patients with vocal cord polyp surgery, clinical need to wake up completely, in order to avoid inhalation of blood and oropharyngeal secretions, many authors have proved that lidocaine provides efficient analgesia without any serious side effects and complications, which can effectively avoid the traditional analgesia method of sedation, dizziness, respiratory depression, nausea, vomiting, and stomach discomfort. [4,5] In this study, the above adverse reactions and toxic reactions of related local anesthetics, such as arrhythmia, circulatory inhibition, convulsions, delayed recovery, unconsciousness, and paresthesia during recovery were still not found.…”

Section: Discussionmentioning

confidence: 99%

The effects of target-controlled infusion of lidocaine undergoing vocal cord polypectomy

Zhou¹,

Wu²,

Cai³

et al. 2022

Medicine

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Background: The present study aimed to assess the efficacy and safety of general anesthesia-assisted target-controlled plasma infusion of lidocaine in patients with vocal cord polypectomy using a supporting laryngoscope.Methods: In total, 80 patients undergoing vocal cord polypectomy using a supporting laryngoscope were randomly divided into an intervention group and a control group; each group contained 40 subjects: both groups received general anesthesia; subjects in the intervention also received an additional 3 mg/L of lidocaine by target-controlled plasma infusion during induction and maintenance of anesthesia; heart rate (HR) mean arterial pressure (MAP), propofol and urapidil consumption (Uradil, which is a blood pressure drug that blocks alpha-1, is called Urapidi Hydrochloride Injection. It is produced by Germany, the enterprise name is Nycomed Deutschland GmbH, the import drug registration number is H20090715, and it is widely used in China), recovery time, and cough score (measured by Minogue et al's 5-grade scoring method) during extubation, and throat pain score (measured by visual analogue scale,[VAS]) after extubation and adverse events were recorded.Results: Significant differences were observed in HR (P < .05) and MAP (P < .05) immediately after intubation (T2), immediately after the operation starting to support laryngoscope exposure (T3), immediately after operation field adrenergic tampon hemostasis (T4), and 5 minutes after hemostasis (T5) between the 2 groups, and significant differences were also observed in HR (P < .05) before intubation (T1). Moreover, significant differences were observed in propofol consumption (P < .05), urapidil consumption (P < .05), cough score during extubation (P < .05), and throat pain score after extubation (P < .05). However, no significant difference was observed in the recovery time (P > .05). Furthermore, no adverse events were detected in either group. Conclusion:The results of this study showed that target-controlled plasma infusion of lidocaine can reduce propofol consumption in patients undergoing vocal cord polypectomy by supporting laryngoscopy, and the hemodynamics are more stable and reduce the coughing reaction in the wake period and throat pain after extubation without adverse events.Abbreviations: AEs = adverse events, ASA = American Society of Anesthesiologists, HR = heart rate, MAP = mean arterial pressure, VAS = visual analogue scale.

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“…Endotracheal intubation in human beings is associated with sympathetic stimulation and increases in heart rate and blood pressure 10. However the response to intubation is not consistently demonstrated in dogs 11. The use of lidocaine to blunt this response is controversial in human beings, and various studies have demonstrated conflicting outcomes in dogs 12 13.…”

Section: Discussionmentioning

confidence: 99%

Anaesthetic management of a phaeochromocytoma excision in a dog

Miller¹,

Pawson²

2019

Vet Record Case Reports

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A nine-year-old male neutered crossbreed dog was presented for adrenalectomy following diagnosis of a phaeochromocytoma, which was confirmed by urinary normetanephrine:creatinine ratio. No clinical signs were associated with the tumour. Excess release of catecholamines from the tumour can result in marked haemodynamic derangements that require careful consideration for anaesthesia. The dog was treated before surgery with phenoxybenzamine per os. During the surgery periods of marked hypertension developed and were managed with nitroprusside and increased vapouriser output. The adrenal gland was closely adhered to the kidney and a nephrectomy was also required to fully excise the mass. A moderate amount of haemorrhage occurred during the final dissection. Hypotension persisted postoperatively and required treatment with phenylephrine and fluid therapy. The dog was discharged from hospital three days following surgery.

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Effect of intravenous lidocaine on cough response to endotracheal intubation in propofol-anaesthetized dogs

Cited by 21 publications

References 34 publications

Anesthetic effects and body weight changes associated with ketamine-xylazine-lidocaine administered to CD-1 mice

Anesthetic effects and body weight changes associated with ketamine-xylazine-lidocaine administered to CD-1 mice

The effects of target-controlled infusion of lidocaine undergoing vocal cord polypectomy

Anaesthetic management of a phaeochromocytoma excision in a dog

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