Effect of intravenous injection of hydrocortisone and lidocaine 2% on pain after propofol injection: a double-blind randomized clinical trial

Vatankhah, Majid; Jarineshin, Hashem; Mehrdad, Melekshoar

doi:10.52547/jmj.17.3.43

Cited by 2 publications

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“…Vatankhah and Melekshoar reported that the intravenous injection of 30 mg ketorolac was more effective than the administration of 400 mg ibuprofen in pain relief among patients undergoing upper extremity orthopedic surgery, especially within the first 6 hours after surgery ( 13 ). The findings of Ebtehaj also indicated that the analgesic effect of the intramuscular administration of ketorolac was similar to that of the intramuscular injection of 75 mg pethidine in post-cesarean section pain management while causing fewer complications ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

et al. 2023

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Background: Postoperative pain management is one of the major challenges of surgeons and anesthesiologists. Objectives: This study aimed to determine the efficacy of topical ketorolac in post-hemorrhoidectomy pain management. Methods: This clinical trial was conducted on 84 candidates for hemorrhoidectomy (grade-II hemorrhoids) who visited Ali ibn Abi-Talib hospital of Rafsanjan, Kerman, Iran (2020 - 2021). The participants were selected through convenience sampling and randomly assigned to three groups of 28. The subjects were treated in topical (4 mL 0.5% Marcaine + 1 mL ketorolac at the surgical site), intramuscular (4 mL 0.5% Marcaine at the surgical site + 1 mL ketorolac intramuscularly), and control (4 mL 0.5% Marcaine at the surgical site) groups. Pain intensity was measured using the Numerical Pain Rating Scale 1, 6, 12, and 24 hours after surgery. The obtained data were analyzed using two-way repeated measures analysis of variance. Results: Female and male patients constituted 46.4% and 53.6% of the participants, respectively. The mean pain intensity was significantly lower in the topical group than in intramuscular and control treatments in all four stages of pain assessment (P < 0.001). Some participants were treated with pethidine due to high pain intensity. However, the mean pain intensity gradually reduced over time in all three groups. Conclusions: Study findings suggested that the topical administration of ketorolac and Marcaine was more effective than Marcaine used alone for relieving pain in patients undergoing hemorrhoidectomy.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

et al. 2023

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“…Finally, the propofol is a group of drugs that stimulate the skin, mucous membranes, and inner walls of the veins [31] . Vatankhah et al [19] in a study concluded that lidocaine reduced pain during propofol injection, and that lidocaine had a greater effect than hydrocortisone. Therefore, the use of these drugs may be able to reduce the pain caused by propofol injection.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of propofol induced pain by thiopentone sodium, fentanyl and lignocaine: A comparative study

David¹

2023

Int. J. Med. Anesthesiology

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Propofol is one of the most popular intravenous anaesthetic used for induction and maintenance of anaesthesia and sedation in and outside of operating room. Its role is valuable especially for day care surgeries and with larngeal mask airways. Because of high incidence of pain on propofol injection (POPI) numerous interventions have been tested to prevent this pain including the use of different drugs and physical measures as well as the combination of methods. In this. study the effect of pretreatment with thiopentone sodium, preservative free fentanyl, and preservative free 2% lignocaine on reducing propofol induced pain with 4 point pain scale. A prospective observational study was conducted in Government Medical College, Kottayam in 63 patients (ASA 1 and 2) in the age group of 18-60 years scheduled for elective surgery under general anaesthesia. Selected patients were allocated into 3 groups: Group T, Group F and Group L. Prior to propofol injection, Group T received thiopentone sodium 0.5mg/kg, Group F received preservative free fentanyl 2 mcg/kg and Group L received preservative free lignocaine 1 mg/kg and pain on propofol injection was assessed during induction of anaesthesia. All patients post induction received standard general anaesthesia. The lowest incidences of pain on propofol injection were observed in Group T, whereas Group L and Group F shown the same incidences of pain on propofol injection. There were no statistically significant differences in the pain perceived between three groups, group L, group F and group T (47.7 v/s 47.7% v/s 33.3%, p=0.170) on propofol injection. Thiopentone sodium was not significantly different from lignocaine for reducing pain during injection of propofol in this study. Fentanyl is equally effective as lignocaine in reducing such pain. The pretreatment with preservative free fentanyl and thiopentone sodium reduced the incidence of propofol induced pain similar to preservative free 2% lignocaine.

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Effect of intravenous injection of hydrocortisone and lidocaine 2% on pain after propofol injection: a double-blind randomized clinical trial

Cited by 2 publications

References 0 publications

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

Effectiveness of Topical Ketorolac in Post-hemorrhoidectomy Pain Management: A Clinical Trial

Attenuation of propofol induced pain by thiopentone sodium, fentanyl and lignocaine: A comparative study

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