Effect of Intravenous Droperidol on Intraocular Pressure and Retrobulbar Hemodynamics

Harris, Alon; Zalish, Miriam; Kagemann, Larry; Siesky, Brent; Migliardi, R.; Garzozi, H.

doi:10.1177/112067210201200304

Cited by 5 publications

(5 citation statements)

References 17 publications

(28 reference statements)

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“…Option of selecting an agent from a different class is thus limited. A previous study observed significant IOP decrease when using droperidol 5 mg intravenously [ 24 ]. In our study, droperidol dosage was considerably lower at 1 mg, with expected less effect on IOP.…”

Section: Discussionmentioning

confidence: 99%

Association of intraocular pressure and postoperative nausea and vomiting after microvascular decompression - a prospective cohort study

et al. 2022

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Background Postoperative nausea and vomiting is common in patients receiving microvascular decompression. In the current study, we examined whether postoperative nausea and vomiting is associated with reduced intraocular pressure (IOP) after microvascular decompression, a measure that reflects intracranial pressure. Methods This is a prospective cohort study. Adult patients scheduled for microvascular decompression surgery for hemifacial spasm between January 2020 and August 2020 were eligible. IOP was measured immediately before anesthesia induction and 30 min after patients regained complete consciousness using non-contact tonometry. IOP reduction was defined by at least 1 mmHg decrease vs. preoperative baseline. The primary outcome was vomiting on postoperative day 1. Results A total of 103 subjects were enrolled. IOP was reduced in 56 (54.4%) subjects. A significantly greater proportion of patients with IOP reduction had vomiting on postoperative day 1 (51.8% (29/56) vs. 23.4% (11/47) in those without IOP reduction; p = 0.003). In the multivariate regression analysis, vomiting on postoperative day 1 was associated with female sex [odds ratio = 7.87, 95% CI: 2.35–26.32, p = 0.001] and IOP reduction [odds ratio = 2.93, 95% CI: 1.13–7.58, p = 0.027]. Conclusions In patients undergoing microvascular decompression surgery, postoperative IOP reduction is associated with postoperative vomiting. Trial registration: Chinese Clinical Trial Registry: ChiCTR2000029083. Registered 13 January 2020.

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Section: Discussionmentioning

confidence: 99%

Association of intraocular pressure and postoperative nausea and vomiting after microvascular decompression - a prospective cohort study

et al. 2022

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“…D 1 antagonists were shown to reduce the IOP in animal models [7,8,9], and some concluded that D 1 antagonists are more effective than timolol in suppressing the IOP recovery from imposed intravenous hyperosmolarity [7, 9, 10]. Harris et al [6 ]have proved recently that intravenous droperidol has a rapid and marked ocular hypotensive effect in healthy young human subjects.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, if administered during induction of anesthesia, droperidol will rapidly lower the IOP, preventing a drastic drop at the time the globe is opened. Harris et al [6] showed that some of this hypotensive effect is present after 60 min, maintaining a lower IOP during surgery. The potent antiemetic antinausea effect may prevent immediate postsurgical complications such as wound dehiscence or prolapse of the iris [5].…”

Section: Discussionmentioning

confidence: 99%

“…The action of a single intramuscular and intravenous dose of droperidol commences 3–10 min after administration, and the peak effect is apparent after up to 30 min [6]. Thus, if administered during induction of anesthesia, droperidol will rapidly lower the IOP, preventing a drastic drop at the time the globe is opened.…”

Section: Discussionmentioning

confidence: 99%

“…In addition it was shown that when administered intravenously, it is potent and safe in lowering the IOP [6]. These effects may better control the intraoperative IOP, and the immediate postoperative nausea and vomiting preventing undesirable complications.…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Droperidol in Perforating Keratoplasty

et al. 2006

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Purpose: To evaluate the intraoperative and postoperative effects of droperidol administered with general anesthesia during perforating keratoplasty. Methods: A prospective, randomized, double-masked clinical trial. Twenty-seven patients undergoing penetrating keratoplasty under general anesthesia were included. Patients were assigned randomly to two groups. Fifteen subjects received droperidol during induction of general anesthesia. Twelve control patients received general anesthesia without droperidol. Results: Droperidol significantly reduced fellow eye intraocular pressure (p < 0.0001). Intraoperative anterior chamber depth was significantly deeper with droperidol (p = 0.0002). Iris bulging was observed in 25% of the control group and 0% with droperidol. There was significantly less postoperative nausea in the droperidol group (p = 0.038). There was less postoperative vomiting in the droperidol group, although the difference was not significant (p = 0.07). Postoperative wound gaping was observed in 2 patients; both of them did not receive droperidol. Conclusions: Droperidol effectively reduces intraoperative and postoperative complications in keratoplasty surgery.

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